Open Access
International Journal of Molecular Sciences, volume 21, issue 21, pages 8122
Desmin Interacts Directly with Mitochondria
Dayal Alexander A
1
,
Medvedeva Natalia V
1
,
Nekrasova Tatiana M
1
,
Duhalin Sergey D
1
,
Surin Alexey K.
1, 2
,
Minin Alexander A.
1
Publication type: Journal Article
Publication date: 2020-10-30
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 16616596, 14220067
PubMed ID:
33143195
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
Desmin intermediate filaments (IFs) play an important role in maintaining the structural and functional integrity of muscle cells. They connect contractile myofibrils to plasma membrane, nuclei, and mitochondria. Disturbance of their network due to desmin mutations or deficiency leads to an infringement of myofibril organization and to a deterioration of mitochondrial distribution, morphology, and functions. The nature of the interaction of desmin IFs with mitochondria is not clear. To elucidate the possibility that desmin can directly bind to mitochondria, we have undertaken the study of their interaction in vitro. Using desmin mutant Des(Y122L) that forms unit-length filaments (ULFs) but is incapable of forming long filaments and, therefore, could be effectively separated from mitochondria by centrifugation through sucrose gradient, we probed the interaction of recombinant human desmin with mitochondria isolated from rat liver. Our data show that desmin can directly bind to mitochondria, and this binding depends on its N-terminal domain. We have found that mitochondrial cysteine protease can disrupt this interaction by cleavage of desmin at its N-terminus.
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1
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3
4
5
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Portland Press
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1 publication, 5.26%
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1
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5
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Dayal A. A. et al. Desmin Interacts Directly with Mitochondria // International Journal of Molecular Sciences. 2020. Vol. 21. No. 21. p. 8122.
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Dayal A. A., Medvedeva N. V., Nekrasova T. M., Duhalin S. D., Surin A. K., Minin A. A. Desmin Interacts Directly with Mitochondria // International Journal of Molecular Sciences. 2020. Vol. 21. No. 21. p. 8122.
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TY - JOUR
DO - 10.3390/ijms21218122
UR - https://doi.org/10.3390%2Fijms21218122
TI - Desmin Interacts Directly with Mitochondria
T2 - International Journal of Molecular Sciences
AU - Dayal, Alexander A
AU - Medvedeva, Natalia V
AU - Nekrasova, Tatiana M
AU - Duhalin, Sergey D
AU - Minin, Alexander A.
AU - Surin, Alexey K.
PY - 2020
DA - 2020/10/30 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 8122
IS - 21
VL - 21
PMID - 33143195
SN - 1661-6596
SN - 1422-0067
ER -
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@article{2020_Dayal,
author = {Alexander A Dayal and Natalia V Medvedeva and Tatiana M Nekrasova and Sergey D Duhalin and Alexander A. Minin and Alexey K. Surin},
title = {Desmin Interacts Directly with Mitochondria},
journal = {International Journal of Molecular Sciences},
year = {2020},
volume = {21},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {oct},
url = {https://doi.org/10.3390%2Fijms21218122},
number = {21},
pages = {8122},
doi = {10.3390/ijms21218122}
}
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Dayal, Alexander A., et al. “Desmin Interacts Directly with Mitochondria.” International Journal of Molecular Sciences, vol. 21, no. 21, Oct. 2020, p. 8122. https://doi.org/10.3390%2Fijms21218122.
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