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International Journal of Molecular Sciences, volume 23, issue 1, pages 292

Implantation of Various Cell-Free Matrixes Does Not Contribute to the Restoration of Hyaline Cartilage within Full-Thickness Focal Defects

Ibragimova Shabnam I 1
Medvedeva Ekaterina V 1
Romanova Irina A 2
Istranov Leonid P 1
Istranova Elena V 1
Nedorubov Andrey A 4
Telpukhov Vladimir I 5
Chagin Andrei S. 1, 6
Publication typeJournal Article
Publication date2021-12-28
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor5.6
ISSN16616596, 14220067
PubMed ID:  35008719
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract

Articular cartilage is a highly organized tissue that has a limited ability to heal. Tissue engineering is actively exploited for joint tissue reconstruction in numerous cases of articular cartilage degeneration associated with trauma, arthrosis, rheumatoid arthritis, and osteoarthritis. However, the optimal scaffolds for cartilage repair are not yet identified. Here we have directly compared five various scaffolds, namely collagen-I membrane, collagen-II membrane, decellularized cartilage, a cellulose-based implant, and commercially available Chondro-Gide® (Geistlich Pharma AG, Wolhusen, Switzerland) collagen membrane. The scaffolds were implanted in osteochondral full-thickness defects, formed on adult Wistar rats using a hand-held cutter with a diameter of 2.0 mm and a depth of up to the subchondral bone. The congruence of the articular surface was almost fully restored by decellularized cartilage and collagen type II-based scaffold. The most vivid restoration was observed 4 months after the implantation. The formation of hyaline cartilage was not detected in any of the groups. Despite cellular infiltration into scaffolds being observed in each group except cellulose, neither chondrocytes nor chondro-progenitors were detected. We concluded that for restoration of hyaline cartilage, scaffolds have to be combined either with cellular therapy or morphogens promoting chondrogenic differentiation.

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Citations by publishers

1
Multidisciplinary Digital Publishing Institute (MDPI)
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1
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Ibragimova S. I. et al. Implantation of Various Cell-Free Matrixes Does Not Contribute to the Restoration of Hyaline Cartilage within Full-Thickness Focal Defects // International Journal of Molecular Sciences. 2021. Vol. 23. No. 1. p. 292.
GOST all authors (up to 50) Copy
Ibragimova S. I., Medvedeva E. V., Romanova I. A., Istranov L. P., Istranova E. V., Lychagin A., Nedorubov A. A., Timashev P. S., Telpukhov V. I., Chagin A. S. Implantation of Various Cell-Free Matrixes Does Not Contribute to the Restoration of Hyaline Cartilage within Full-Thickness Focal Defects // International Journal of Molecular Sciences. 2021. Vol. 23. No. 1. p. 292.
RIS |
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RIS Copy
TY - JOUR
DO - 10.3390/ijms23010292
UR - https://doi.org/10.3390%2Fijms23010292
TI - Implantation of Various Cell-Free Matrixes Does Not Contribute to the Restoration of Hyaline Cartilage within Full-Thickness Focal Defects
T2 - International Journal of Molecular Sciences
AU - Ibragimova, Shabnam I
AU - Medvedeva, Ekaterina V
AU - Telpukhov, Vladimir I
AU - Romanova, Irina A
AU - Istranov, Leonid P
AU - Istranova, Elena V
AU - Nedorubov, Andrey A
AU - Chagin, Andrei S.
AU - Lychagin, Alexey
AU - Timashev, Petr S.
PY - 2021
DA - 2021/12/28 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 292
IS - 1
VL - 23
PMID - 35008719
SN - 1661-6596
SN - 1422-0067
ER -
BibTex |
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BibTex Copy
@article{2021_Ibragimova
author = {Shabnam I Ibragimova and Ekaterina V Medvedeva and Vladimir I Telpukhov and Irina A Romanova and Leonid P Istranov and Elena V Istranova and Andrey A Nedorubov and Andrei S. Chagin and Alexey Lychagin and Petr S. Timashev},
title = {Implantation of Various Cell-Free Matrixes Does Not Contribute to the Restoration of Hyaline Cartilage within Full-Thickness Focal Defects},
journal = {International Journal of Molecular Sciences},
year = {2021},
volume = {23},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {dec},
url = {https://doi.org/10.3390%2Fijms23010292},
number = {1},
pages = {292},
doi = {10.3390/ijms23010292}
}
MLA
Cite this
MLA Copy
Ibragimova, Shabnam I., et al. “Implantation of Various Cell-Free Matrixes Does Not Contribute to the Restoration of Hyaline Cartilage within Full-Thickness Focal Defects.” International Journal of Molecular Sciences, vol. 23, no. 1, Dec. 2021, p. 292. https://doi.org/10.3390%2Fijms23010292.
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