Open Access
International Journal of Molecular Sciences, volume 23, issue 5, pages 2771
Hybrid Nanoparticles and Composite Hydrogel Systems for Delivery of Peptide Antibiotics
Iudin Dmitrii
1, 2
,
Vasilieva Marina
1
,
Knyazeva Elena
3
,
Korzhikov Vlakh Viktor
2
,
Demyanova Elena
3
,
Skorik Yury A.
1
,
4
Institute of Technical Chemistry, Gottfried-Wilhelm-Leibniz University of Hannover, 30167 Hannover, Germany
|
Publication type: Journal Article
Publication date: 2022-03-02
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 16616596, 14220067
PubMed ID:
35269910
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
The growing number of drug-resistant pathogenic bacteria poses a global threat to human health. For this reason, the search for ways to enhance the antibacterial activity of existing antibiotics is now an urgent medical task. The aim of this study was to develop novel delivery systems for polymyxins to improve their antimicrobial properties against various infections. For this, hybrid core–shell nanoparticles, consisting of silver core and a poly(glutamic acid) shell capable of polymyxin binding, were developed and carefully investigated. Characterization of the hybrid nanoparticles revealed a hydrodynamic diameter of approximately 100 nm and a negative electrokinetic potential. The nanoparticles demonstrated a lack of cytotoxicity, a low uptake by macrophages, and their own antimicrobial activity. Drug loading and loading efficacy were determined for both polymyxin B and E, and the maximal loaded value with an appropriate size of the delivery systems was 450 µg/mg of nanoparticles. Composite materials based on agarose hydrogel were prepared, containing both the loaded hybrid systems and free antibiotics. The features of polymyxin release from the hybrid nanoparticles and the composite materials were studied, and the mechanisms of release were analyzed using different theoretical models. The antibacterial activity against Pseudomonas aeruginosa was evaluated for both the polymyxin hybrid and the composite delivery systems. All tested samples inhibited bacterial growth. The minimal inhibitory concentrations of the polymyxin B hybrid delivery system demonstrated a synergistic effect when compared with either the antibiotic or the silver nanoparticles alone.
Citations by journals
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1
2
3
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
3 publications, 37.5%
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Journal of Controlled Release
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Journal of Controlled Release
1 publication, 12.5%
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International Journal of Pharmaceutics
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International Journal of Pharmaceutics
1 publication, 12.5%
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Journal of Nanobiotechnology
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Journal of Nanobiotechnology
1 publication, 12.5%
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Pharmaceutics
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Pharmaceutics
1 publication, 12.5%
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Advances in Colloid and Interface Science
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Advances in Colloid and Interface Science
1 publication, 12.5%
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1
2
3
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Citations by publishers
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1
2
3
4
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
4 publications, 50%
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Elsevier
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Elsevier
3 publications, 37.5%
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Springer Nature
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Springer Nature
1 publication, 12.5%
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1
2
3
4
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Iudin D. et al. Hybrid Nanoparticles and Composite Hydrogel Systems for Delivery of Peptide Antibiotics // International Journal of Molecular Sciences. 2022. Vol. 23. No. 5. p. 2771.
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Iudin D., Vasilieva M., Knyazeva E., Korzhikov Vlakh V., Demyanova E., Lavrentieva A., Skorik Y. A., Korzhikova-Vlakh E. Hybrid Nanoparticles and Composite Hydrogel Systems for Delivery of Peptide Antibiotics // International Journal of Molecular Sciences. 2022. Vol. 23. No. 5. p. 2771.
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TY - JOUR
DO - 10.3390/ijms23052771
UR - https://doi.org/10.3390%2Fijms23052771
TI - Hybrid Nanoparticles and Composite Hydrogel Systems for Delivery of Peptide Antibiotics
T2 - International Journal of Molecular Sciences
AU - Iudin, Dmitrii
AU - Vasilieva, Marina
AU - Knyazeva, Elena
AU - Demyanova, Elena
AU - Korzhikov Vlakh, Viktor
AU - Lavrentieva, Antonina
AU - Skorik, Yury A.
AU - Korzhikova-Vlakh, Evgenia
PY - 2022
DA - 2022/03/02 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 2771
IS - 5
VL - 23
PMID - 35269910
SN - 1661-6596
SN - 1422-0067
ER -
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@article{2022_Iudin,
author = {Dmitrii Iudin and Marina Vasilieva and Elena Knyazeva and Elena Demyanova and Viktor Korzhikov Vlakh and Antonina Lavrentieva and Yury A. Skorik and Evgenia Korzhikova-Vlakh},
title = {Hybrid Nanoparticles and Composite Hydrogel Systems for Delivery of Peptide Antibiotics},
journal = {International Journal of Molecular Sciences},
year = {2022},
volume = {23},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {mar},
url = {https://doi.org/10.3390%2Fijms23052771},
number = {5},
pages = {2771},
doi = {10.3390/ijms23052771}
}
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Iudin, Dmitrii, et al. “Hybrid Nanoparticles and Composite Hydrogel Systems for Delivery of Peptide Antibiotics.” International Journal of Molecular Sciences, vol. 23, no. 5, Mar. 2022, p. 2771. https://doi.org/10.3390%2Fijms23052771.