Open Access
Open access
International Journal of Molecular Sciences, volume 23, issue 13, pages 7464

Size-Dependent Cytoprotective Effects of Selenium Nanoparticles during Oxygen-Glucose Deprivation in Brain Cortical Cells

Publication typeJournal Article
Publication date2022-07-05
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor5.6
ISSN16616596, 14220067
PubMed ID:  35806466
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract

It is known that selenium nanoparticles (SeNPs) obtained on their basis have a pleiotropic effect, inducing the process of apoptosis in tumor cells, on the one hand, and protecting healthy tissue cells from death under stress, on the other hand. It has been established that SeNPs protect brain cells from ischemia/reoxygenation through activation of the Ca2+ signaling system of astrocytes and reactive astrogliosis. At the same time, for a number of particles, the limitations of their use, associated with their size, are shown. The use of nanoparticles with a diameter of less than 10 nm leads to their short life-time in the bloodstream and rapid removal by the liver. Nanoparticles larger than 200 nm activate the complement system and are also quickly removed from the blood. The effects of different-sized SeNPs on brain cells have hardly been studied. Using the laser ablation method, we obtained SeNPs of various diameters: 50 nm, 100 nm, and 400 nm. Using fluorescence microscopy, vitality tests, PCR analysis, and immunocytochemistry, it was shown that all three types of the different-sized SeNPs have a cytoprotective effect on brain cortex cells under conditions of oxygen-glucose deprivation (OGD) and reoxygenation (R), suppressing the processes of necrotic death and inhibiting different efficiency processes of apoptosis. All of the studied SeNPs activate the Ca2+ signaling system of astrocytes, while simultaneously inducing different types of Ca2+ signals. SeNPs sized at 50 nm- induce Ca2+ responses of astrocytes in the form of a gradual irreversible increase in the concentration of cytosolic Ca2+ ([Ca2+]i), 100 nm-sized SeNPs induce stable Ca2+ oscillations without increasing the base level of [Ca2+]i, and 400 nm-sized SeNPs cause mixed patterns of Ca2+ signals. Such differences in the level of astrocyte Ca2+ signaling can explain the different cytoprotective efficacy of SeNPs, which is expressed in the expression of protective proteins and the activation of reactive astrogliosis. In terms of the cytoprotective efficiency under OGD/R conditions, different-sized SeNPs can be arranged in descending order: 100 nm-sized > 400 nm-sized > 50 nm-sized.

Citations by journals

1
2
3
4
5
6
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 6, 33.33%
International Journal of Molecular Sciences
6 publications, 33.33%
Pharmaceutics
Pharmaceutics, 2, 11.11%
Pharmaceutics
2 publications, 11.11%
Frontiers in Immunology
Frontiers in Immunology, 1, 5.56%
Frontiers in Immunology
1 publication, 5.56%
Antioxidants
Antioxidants, 1, 5.56%
Antioxidants
1 publication, 5.56%
Colloids and Interfaces
Colloids and Interfaces, 1, 5.56%
Colloids and Interfaces
1 publication, 5.56%
Microorganisms
Microorganisms, 1, 5.56%
Microorganisms
1 publication, 5.56%
Materials
Materials, 1, 5.56%
Materials
1 publication, 5.56%
Applied Sciences (Switzerland)
Applied Sciences (Switzerland), 1, 5.56%
Applied Sciences (Switzerland)
1 publication, 5.56%
Cells
Cells, 1, 5.56%
Cells
1 publication, 5.56%
Nanomaterials
Nanomaterials, 1, 5.56%
Nanomaterials
1 publication, 5.56%
FEBS Journal
FEBS Journal, 1, 5.56%
FEBS Journal
1 publication, 5.56%
1
2
3
4
5
6

Citations by publishers

2
4
6
8
10
12
14
16
Multidisciplinary Digital Publishing Institute (MDPI)
Multidisciplinary Digital Publishing Institute (MDPI), 15, 83.33%
Multidisciplinary Digital Publishing Institute (MDPI)
15 publications, 83.33%
Frontiers Media S.A.
Frontiers Media S.A., 1, 5.56%
Frontiers Media S.A.
1 publication, 5.56%
Wiley
Wiley, 1, 5.56%
Wiley
1 publication, 5.56%
2
4
6
8
10
12
14
16
  • We do not take into account publications that without a DOI.
  • Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
  • Statistics recalculated weekly.
Metrics
Share
Cite this
GOST |
Cite this
GOST Copy
Varlamova E. G. et al. Size-Dependent Cytoprotective Effects of Selenium Nanoparticles during Oxygen-Glucose Deprivation in Brain Cortical Cells // International Journal of Molecular Sciences. 2022. Vol. 23. No. 13. p. 7464.
GOST all authors (up to 50) Copy
Varlamova E. G., Gudkov S. V., Plotnikov E. Yu., Turovsky E. A. Size-Dependent Cytoprotective Effects of Selenium Nanoparticles during Oxygen-Glucose Deprivation in Brain Cortical Cells // International Journal of Molecular Sciences. 2022. Vol. 23. No. 13. p. 7464.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.3390/ijms23137464
UR - https://doi.org/10.3390%2Fijms23137464
TI - Size-Dependent Cytoprotective Effects of Selenium Nanoparticles during Oxygen-Glucose Deprivation in Brain Cortical Cells
T2 - International Journal of Molecular Sciences
AU - Varlamova, Elena G.
AU - Gudkov, Sergey V.
AU - Plotnikov, Egor Yu
AU - Turovsky, E. A.
PY - 2022
DA - 2022/07/05 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 7464
IS - 13
VL - 23
PMID - 35806466
SN - 1661-6596
SN - 1422-0067
ER -
BibTex |
Cite this
BibTex Copy
@article{2022_Varlamova
author = {Elena G. Varlamova and Sergey V. Gudkov and Egor Yu Plotnikov and E. A. Turovsky},
title = {Size-Dependent Cytoprotective Effects of Selenium Nanoparticles during Oxygen-Glucose Deprivation in Brain Cortical Cells},
journal = {International Journal of Molecular Sciences},
year = {2022},
volume = {23},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jul},
url = {https://doi.org/10.3390%2Fijms23137464},
number = {13},
pages = {7464},
doi = {10.3390/ijms23137464}
}
MLA
Cite this
MLA Copy
Varlamova, Elena G., et al. “Size-Dependent Cytoprotective Effects of Selenium Nanoparticles during Oxygen-Glucose Deprivation in Brain Cortical Cells.” International Journal of Molecular Sciences, vol. 23, no. 13, Jul. 2022, p. 7464. https://doi.org/10.3390%2Fijms23137464.
Found error?