Open Access
Hypochlorous Acid Chemistry in Mammalian Cells—Influence on Infection and Role in Various Pathologies
Celia María Curieses Andrés
1
,
José M. Pérez de la Lastra
2
,
Celia Andrés Juan
3
,
Francisco Plou
4
,
Eduardo Pérez Lebeña
5
1
5
Sistemas de Biotecnología y Recursos Naturales, 47625 Valladolid, Spain
|
Publication type: Journal Article
Publication date: 2022-09-14
scimago Q1
wos Q1
SJR: 1.273
CiteScore: 9.0
Impact factor: 4.9
ISSN: 16616596, 14220067
PubMed ID:
36142645
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
This review discusses the formation of hypochlorous acid HOCl and the role of reactive chlorinated species (RCS), which are catalysed by the enzyme myeloperoxidase MPO, mainly located in leukocytes and which in turn contribute to cellular oxidative stress. The reactions of RCS with various organic molecules such as amines, amino acids, proteins, lipids, carbohydrates, nucleic acids, and DNA are described, and an attempt is made to explain the chemical mechanisms of the formation of the various chlorinated derivatives and the data available so far on the effects of MPO, RCS and halogenative stress. Their presence in numerous pathologies such as atherosclerosis, arthritis, neurological and renal diseases, diabetes, and obesity is reviewed and were found to be a feature of debilitating diseases.
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Metrics
104
Total citations:
104
Citations from 2024:
79
(75.96%)
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GOST
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Andrés C. M. C. et al. Hypochlorous Acid Chemistry in Mammalian Cells—Influence on Infection and Role in Various Pathologies // International Journal of Molecular Sciences. 2022. Vol. 23. No. 18. p. 10735.
GOST all authors (up to 50)
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Andrés C. M. C., Pérez de la Lastra J. M., Juan C. A., Plou F., Pérez Lebeña E. Hypochlorous Acid Chemistry in Mammalian Cells—Influence on Infection and Role in Various Pathologies // International Journal of Molecular Sciences. 2022. Vol. 23. No. 18. p. 10735.
Cite this
RIS
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TY - JOUR
DO - 10.3390/ijms231810735
UR - https://doi.org/10.3390/ijms231810735
TI - Hypochlorous Acid Chemistry in Mammalian Cells—Influence on Infection and Role in Various Pathologies
T2 - International Journal of Molecular Sciences
AU - Andrés, Celia María Curieses
AU - Pérez de la Lastra, José M.
AU - Juan, Celia Andrés
AU - Plou, Francisco
AU - Pérez Lebeña, Eduardo
PY - 2022
DA - 2022/09/14
PB - MDPI
SP - 10735
IS - 18
VL - 23
PMID - 36142645
SN - 1661-6596
SN - 1422-0067
ER -
Cite this
BibTex (up to 50 authors)
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@article{2022_Andrés,
author = {Celia María Curieses Andrés and José M. Pérez de la Lastra and Celia Andrés Juan and Francisco Plou and Eduardo Pérez Lebeña},
title = {Hypochlorous Acid Chemistry in Mammalian Cells—Influence on Infection and Role in Various Pathologies},
journal = {International Journal of Molecular Sciences},
year = {2022},
volume = {23},
publisher = {MDPI},
month = {sep},
url = {https://doi.org/10.3390/ijms231810735},
number = {18},
pages = {10735},
doi = {10.3390/ijms231810735}
}
Cite this
MLA
Copy
Andrés, Celia María Curieses, et al. “Hypochlorous Acid Chemistry in Mammalian Cells—Influence on Infection and Role in Various Pathologies.” International Journal of Molecular Sciences, vol. 23, no. 18, Sep. 2022, p. 10735. https://doi.org/10.3390/ijms231810735.