Open Access
Diastereoselective Synthesis of Novel Spiro-Phosphacoumarins and Evaluation of Their Anti-Cancer Activity
Тип публикации: Journal Article
Дата публикации: 2022-11-18
scimago Q1
wos Q1
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SJR: 1.273
CiteScore: 9.0
Impact factor: 4.9
ISSN: 16616596, 14220067
PubMed ID:
36430824
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Краткое описание
Herein we present the regio- and diastereoselective synthesis of novel pyrrolidine-fused spiro-dihydrophosphacoumarins via intermolecular [3 + 2] cycloaddition reaction. The presented approach is complementary to existing ones and provides an easy entry to the otherwise inaccessible derivatives. Additionally, the unprecedented pathway of the reaction of 4-hydroxycoumarin with azomethine ylides is described. The anti-cancer activity of the obtained compounds was tested in vitro, the most potent compound being 2.6-fold more active against the HuTu 80 cell line than the reference 5-fluorouracil, with a selectivity index > 32.
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Sennikova V. V. et al. Diastereoselective Synthesis of Novel Spiro-Phosphacoumarins and Evaluation of Their Anti-Cancer Activity // International Journal of Molecular Sciences. 2022. Vol. 23. No. 22. p. 14348.
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Sennikova V. V., Zalaltdinova A. V., Sadykova Y. M., Khamatgalimov A., Gazizov A. S., Voloshina A. D., Lyubina A. P., Amerhanova S. K., Voronina J. K., Chugunova E., Appazov N. O., Burilov A. R., Pudovik M. A. Diastereoselective Synthesis of Novel Spiro-Phosphacoumarins and Evaluation of Their Anti-Cancer Activity // International Journal of Molecular Sciences. 2022. Vol. 23. No. 22. p. 14348.
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TY - JOUR
DO - 10.3390/ijms232214348
UR - https://doi.org/10.3390/ijms232214348
TI - Diastereoselective Synthesis of Novel Spiro-Phosphacoumarins and Evaluation of Their Anti-Cancer Activity
T2 - International Journal of Molecular Sciences
AU - Sennikova, Valeriia V
AU - Zalaltdinova, Alena V
AU - Sadykova, Yulia M
AU - Khamatgalimov, A.R
AU - Gazizov, Almir S.
AU - Voloshina, A. D.
AU - Lyubina, Anna P
AU - Amerhanova, Syumbelya K
AU - Voronina, Julia K.
AU - Chugunova, Elena
AU - Appazov, Nurbol Orynbasaruly
AU - Burilov, Alexander R
AU - Pudovik, Michail A.
PY - 2022
DA - 2022/11/18
PB - MDPI
SP - 14348
IS - 22
VL - 23
PMID - 36430824
SN - 1661-6596
SN - 1422-0067
ER -
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@article{2022_Sennikova,
author = {Valeriia V Sennikova and Alena V Zalaltdinova and Yulia M Sadykova and A.R Khamatgalimov and Almir S. Gazizov and A. D. Voloshina and Anna P Lyubina and Syumbelya K Amerhanova and Julia K. Voronina and Elena Chugunova and Nurbol Orynbasaruly Appazov and Alexander R Burilov and Michail A. Pudovik},
title = {Diastereoselective Synthesis of Novel Spiro-Phosphacoumarins and Evaluation of Their Anti-Cancer Activity},
journal = {International Journal of Molecular Sciences},
year = {2022},
volume = {23},
publisher = {MDPI},
month = {nov},
url = {https://doi.org/10.3390/ijms232214348},
number = {22},
pages = {14348},
doi = {10.3390/ijms232214348}
}
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MLA
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Sennikova, Valeriia V., et al. “Diastereoselective Synthesis of Novel Spiro-Phosphacoumarins and Evaluation of Their Anti-Cancer Activity.” International Journal of Molecular Sciences, vol. 23, no. 22, Nov. 2022, p. 14348. https://doi.org/10.3390/ijms232214348.