Open Access
Natural Products and Their Derivatives as Inhibitors of the DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1
Alexandra L. Zakharenko
1
,
Olga A. Luzina
2
,
Arina A. Chepanova
1
,
Nadezhda S. Dyrkheeva
1
,
Nariman F. Salakhutdinov
2
,
Publication type: Journal Article
Publication date: 2023-03-17
scimago Q1
wos Q1
SJR: 1.273
CiteScore: 9.0
Impact factor: 4.9
ISSN: 16616596, 14220067
PubMed ID:
36982848
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is an important repair enzyme that removes various covalent adducts from the 3′ end of DNA. Particularly, covalent complexes of topoisomerase 1 (TOP1) with DNA stabilized by DNA damage or by various chemical agents are an examples of such adducts. Anticancer drugs such as the TOP1 poisons topotecan and irinotecan are responsible for the stabilization of these complexes. TDP1 neutralizes the effect of these anticancer drugs, eliminating the DNA adducts. Therefore, the inhibition of TDP1 can sensitize tumor cells to the action of TOP1 poisons. This review contains information about methods for determining the TDP1 activity, as well as describing the inhibitors of these enzyme derivatives of natural biologically active substances, such as aminoglycosides, nucleosides, polyphenolic compounds, and terpenoids. Data on the efficiency of combined inhibition of TOP1 and TDP1 in vitro and in vivo are presented.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
3
4
5
|
|
|
International Journal of Molecular Sciences
5 publications, 19.23%
|
|
|
Russian Chemical Bulletin
2 publications, 7.69%
|
|
|
Genes
1 publication, 3.85%
|
|
|
Surgery (US)
1 publication, 3.85%
|
|
|
MolBank
1 publication, 3.85%
|
|
|
Medicinal Chemistry Research
1 publication, 3.85%
|
|
|
Russian Journal of Organic Chemistry
1 publication, 3.85%
|
|
|
Biochimica et Biophysica Acta - General Subjects
1 publication, 3.85%
|
|
|
Bulletin of Experimental Biology and Medicine
1 publication, 3.85%
|
|
|
European Journal of Medicinal Chemistry
1 publication, 3.85%
|
|
|
Russian Chemical Reviews
1 publication, 3.85%
|
|
|
Communications Chemistry
1 publication, 3.85%
|
|
|
Журнал органической химии
1 publication, 3.85%
|
|
|
Arabian Journal of Chemistry
1 publication, 3.85%
|
|
|
Bioorganic Chemistry
1 publication, 3.85%
|
|
|
Chemistry
1 publication, 3.85%
|
|
|
RSC Medicinal Chemistry
1 publication, 3.85%
|
|
|
Frontiers in Nutrition
1 publication, 3.85%
|
|
|
Scientific Reports
1 publication, 3.85%
|
|
|
Clinical Rheumatology
1 publication, 3.85%
|
|
|
Molecular Biology
1 publication, 3.85%
|
|
|
1
2
3
4
5
|
Publishers
|
1
2
3
4
5
6
7
8
|
|
|
MDPI
8 publications, 30.77%
|
|
|
Springer Nature
7 publications, 26.92%
|
|
|
Elsevier
4 publications, 15.38%
|
|
|
Pleiades Publishing
2 publications, 7.69%
|
|
|
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 3.85%
|
|
|
Akademizdatcenter Nauka
1 publication, 3.85%
|
|
|
Scientific Scholar
1 publication, 3.85%
|
|
|
Royal Society of Chemistry (RSC)
1 publication, 3.85%
|
|
|
Frontiers Media S.A.
1 publication, 3.85%
|
|
|
1
2
3
4
5
6
7
8
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
26
Total citations:
26
Citations from 2024:
20
(76.93%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Zakharenko A. L. et al. Natural Products and Their Derivatives as Inhibitors of the DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1 // International Journal of Molecular Sciences. 2023. Vol. 24. No. 6. p. 5781.
GOST all authors (up to 50)
Copy
Zakharenko A. L., Luzina O. A., Chepanova A. A., Dyrkheeva N. S., Salakhutdinov N. F., Лаврик О. И. Natural Products and Their Derivatives as Inhibitors of the DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1 // International Journal of Molecular Sciences. 2023. Vol. 24. No. 6. p. 5781.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/ijms24065781
UR - https://doi.org/10.3390/ijms24065781
TI - Natural Products and Their Derivatives as Inhibitors of the DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1
T2 - International Journal of Molecular Sciences
AU - Zakharenko, Alexandra L.
AU - Luzina, Olga A.
AU - Chepanova, Arina A.
AU - Dyrkheeva, Nadezhda S.
AU - Salakhutdinov, Nariman F.
AU - Лаврик, О. И.
PY - 2023
DA - 2023/03/17
PB - MDPI
SP - 5781
IS - 6
VL - 24
PMID - 36982848
SN - 1661-6596
SN - 1422-0067
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2023_Zakharenko,
author = {Alexandra L. Zakharenko and Olga A. Luzina and Arina A. Chepanova and Nadezhda S. Dyrkheeva and Nariman F. Salakhutdinov and О. И. Лаврик},
title = {Natural Products and Their Derivatives as Inhibitors of the DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1},
journal = {International Journal of Molecular Sciences},
year = {2023},
volume = {24},
publisher = {MDPI},
month = {mar},
url = {https://doi.org/10.3390/ijms24065781},
number = {6},
pages = {5781},
doi = {10.3390/ijms24065781}
}
Cite this
MLA
Copy
Zakharenko, Alexandra L., et al. “Natural Products and Their Derivatives as Inhibitors of the DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1.” International Journal of Molecular Sciences, vol. 24, no. 6, Mar. 2023, p. 5781. https://doi.org/10.3390/ijms24065781.
Profiles