Open Access

International Journal of Molecular Sciences

, volume 24 , issue 8 , pages 6882

Exploring the Conformational Equilibrium of Mefenamic Acid Released from Silica Aerogels via NMR Analysis

Ilya A. Khodov ¹

Valentina V Sobornova ¹

Valeriya Mulloyarova ²

Konstantin V. Belov ¹

Alexey A. Dyshin ¹

Luís A. E. Batista de Carvalho ³

Peter M. Tolstoy ²

Michael Kiselev ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

G.A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences, Ivanovo 153045, Russia |

Institute of Chemistry, Saint Petersburg State University, Saint Petersburg 198504, Russia |

Molecular Physical-Chemistry R&D Unit, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal |

Publication type: Journal Article

Publication date: 2023-04-07

MDPI

International Journal of Molecular Sciences

scimago Q1

wos Q1

SJR: 1.273

CiteScore: 9.0

Impact factor: 4.9

ISSN: 16616596, 14220067

DOI: 10.3390/ijms24086882

Copy DOI

PubMed ID: 37108046

Catalysis

Organic Chemistry

Inorganic Chemistry

Physical and Theoretical Chemistry

Computer Science Applications

Spectroscopy

Molecular Biology

General Medicine

Abstract

This study examines the influence of mefenamic acid on the physical and chemical properties of silica aerogels, as well as its effect on the sorption characteristics of the composite material. Solid state magic angle spinning nuclear magnetic resonance (MAS NMR) and high-pressure 13C NMR kinetic studies were conducted to identify the presence of mefenamic acid and measure the kinetic rates of CO2 sorption. Additionally, a high-pressure T1–T2 relaxation-relaxation correlation spectroscopy (RRCOSY) study was conducted to estimate the relative amount of mefenamic acid in the aerogel’s pores, and a high-pressure nuclear Overhauser effect spectoscopy (NOESY) study was conducted to investigate the conformational preference of mefenamic acid released from the aerogel. The results indicate that mefenamic acid is affected by the chemical environment of the aerogel, altering the ratio of mefenamic acid conformers from 75% to 25% in its absence to 22% to 78% in the presence of aerogel.

Found

6 citations

Khodov Ilya

🥼 🤝

DSc in Physics and Mathematics

101 publications, 1 268 citations, 410 reviews

h-index: 21

G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences

N.N. Semenov Federal Research Center for Chemical Physics of the Russian Academy of Sciences

4 citations

Belov Konstantin

🤝

PhD in Chemistry

32 publications, 359 citations

h-index: 12

G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences

3 citations

Dyshin Alexey

PhD in Chemistry

50 publications, 473 citations, 2 reviews

h-index: 13

G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences

2 citations

Sobornova Valentina

14 publications, 120 citations

h-index: 8

G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences

Research interests

Small molecules

Sorption

2 citations

Budkov Yury

🥼 🤝

DSc in Physics and Mathematics

100 publications, 1 274 citations, 56 reviews

h-index: 20

National Research University Higher School of Economics

G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences

A.N. Frumkin Institute of Physical Chemistry and Electrochemistry of the Russian Academy of Sciences

1 citation

Krestianinov Mikhail

88 publications, 751 citations, 20 reviews

h-index: 15

G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences

1 citation

Gurina Darya

PhD in Chemistry

63 publications, 449 citations

h-index: 12

G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences

Research interests

Chemical physics

Computational chemistry

1 citation

Kalikin Nikolai

22 publications, 233 citations

h-index: 9

National Research University Higher School of Economics

G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences

Ivanovo State University

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GOST |

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Khodov I. A. et al. Exploring the Conformational Equilibrium of Mefenamic Acid Released from Silica Aerogels via NMR Analysis // International Journal of Molecular Sciences. 2023. Vol. 24. No. 8. p. 6882.

GOST all authors (up to 50) Copy

Khodov I. A., Sobornova V. V., Mulloyarova V., Belov K. V., Dyshin A. A., Batista de Carvalho L. A. E., Tolstoy P. M., Kiselev M. Exploring the Conformational Equilibrium of Mefenamic Acid Released from Silica Aerogels via NMR Analysis // International Journal of Molecular Sciences. 2023. Vol. 24. No. 8. p. 6882.

RIS |

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RIS Copy

TY - JOUR

DO - 10.3390/ijms24086882

UR - https://doi.org/10.3390/ijms24086882

TI - Exploring the Conformational Equilibrium of Mefenamic Acid Released from Silica Aerogels via NMR Analysis

T2 - International Journal of Molecular Sciences

AU - Khodov, Ilya A.

AU - Sobornova, Valentina V

AU - Mulloyarova, Valeriya

AU - Belov, Konstantin V.

AU - Dyshin, Alexey A.

AU - Batista de Carvalho, Luís A. E.

AU - Tolstoy, Peter M.

AU - Kiselev, Michael

PY - 2023

DA - 2023/04/07

PB - MDPI

SP - 6882

IS - 8

VL - 24

PMID - 37108046

SN - 1661-6596

SN - 1422-0067

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2023_Khodov,

author = {Ilya A. Khodov and Valentina V Sobornova and Valeriya Mulloyarova and Konstantin V. Belov and Alexey A. Dyshin and Luís A. E. Batista de Carvalho and Peter M. Tolstoy and Michael Kiselev},

title = {Exploring the Conformational Equilibrium of Mefenamic Acid Released from Silica Aerogels via NMR Analysis},

journal = {International Journal of Molecular Sciences},

year = {2023},

volume = {24},

publisher = {MDPI},

month = {apr},

url = {https://doi.org/10.3390/ijms24086882},

number = {8},

pages = {6882},

doi = {10.3390/ijms24086882}

}

MLA

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MLA Copy

Khodov, Ilya A., et al. “Exploring the Conformational Equilibrium of Mefenamic Acid Released from Silica Aerogels via NMR Analysis.” International Journal of Molecular Sciences, vol. 24, no. 8, Apr. 2023, p. 6882. https://doi.org/10.3390/ijms24086882.

Publisher

MDPI

Journal

International Journal of Molecular Sciences

scimago Q1

wos Q1

SJR

1.273

CiteScore

9.0

Impact factor

4.9

ISSN

16616596 (Print)

14220067 (Electronic)

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