Open Access
Synthesis and Anticancer Evaluation of Novel 7-Aza-Coumarine-3-Carboxamides
Alexey V Trifonov
1
,
Almir S. Gazizov
1
,
Anipa S. Tapalova
2
,
Lyudmila K Kibardina
1
,
Alexandra D Voloshina
1
,
Anastasiia S Sapunova
1
,
Anna P. Luybina
1
,
Gulmira M. Abyzbekova
2
,
Alexey B. Dobrynin
1
,
Igor A Litvinov
1
,
Akerke K. Tauekel
3
,
Sholpan O. Yespenbetova
2
,
Alexander R Burilov
1
,
Michail A. Pudovik
1
2
Korkyt Ata Kyzylorda University, Aiteke Bi Street, 29A, Kyzylorda 120014, Kazakhstan
|
Publication type: Journal Article
Publication date: 2023-06-09
scimago Q1
wos Q1
SJR: 1.273
CiteScore: 9.0
Impact factor: 4.9
ISSN: 16616596, 14220067
PubMed ID:
37373075
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
Herein, we report the design and synthesis of novel 7-aza-coumarine-3-carboxamides via scaffold-hopping strategy and evaluation of their in vitro anticancer activity. Additionally, the improved non-catalytic synthesis of 7-azacoumarin-3-carboxylic acid is reported, which features water as the reaction medium and provides a convenient alternative to the known methods. The anticancer activity of the most potent 7-aza-coumarine-3-carboxamides against the HuTu 80 cell line is equal to that of reference Doxorubicin, while the selectivity towards the normal cell line is 9–14 fold higher.
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6
Total citations:
6
Citations from 2025:
2
(33.33%)
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GOST
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Trifonov A. V. et al. Synthesis and Anticancer Evaluation of Novel 7-Aza-Coumarine-3-Carboxamides // International Journal of Molecular Sciences. 2023. Vol. 24. No. 12. p. 9927.
GOST all authors (up to 50)
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Trifonov A. V., Gazizov A. S., Tapalova A. S., Kibardina L. K., Appazov N. O., Voloshina A. D., Sapunova A. S., Luybina A. P., Abyzbekova G. M., Dobrynin A. B., Litvinov I. A., Tauekel A. K., Yespenbetova S. O., Burilov A. R., Pudovik M. A. Synthesis and Anticancer Evaluation of Novel 7-Aza-Coumarine-3-Carboxamides // International Journal of Molecular Sciences. 2023. Vol. 24. No. 12. p. 9927.
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RIS
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TY - JOUR
DO - 10.3390/ijms24129927
UR - https://doi.org/10.3390/ijms24129927
TI - Synthesis and Anticancer Evaluation of Novel 7-Aza-Coumarine-3-Carboxamides
T2 - International Journal of Molecular Sciences
AU - Trifonov, Alexey V
AU - Gazizov, Almir S.
AU - Tapalova, Anipa S.
AU - Kibardina, Lyudmila K
AU - Appazov, Nurbol Orynbasaruly
AU - Voloshina, Alexandra D
AU - Sapunova, Anastasiia S
AU - Luybina, Anna P.
AU - Abyzbekova, Gulmira M.
AU - Dobrynin, Alexey B.
AU - Litvinov, Igor A
AU - Tauekel, Akerke K.
AU - Yespenbetova, Sholpan O.
AU - Burilov, Alexander R
AU - Pudovik, Michail A.
PY - 2023
DA - 2023/06/09
PB - MDPI
SP - 9927
IS - 12
VL - 24
PMID - 37373075
SN - 1661-6596
SN - 1422-0067
ER -
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BibTex (up to 50 authors)
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@article{2023_Trifonov,
author = {Alexey V Trifonov and Almir S. Gazizov and Anipa S. Tapalova and Lyudmila K Kibardina and Nurbol Orynbasaruly Appazov and Alexandra D Voloshina and Anastasiia S Sapunova and Anna P. Luybina and Gulmira M. Abyzbekova and Alexey B. Dobrynin and Igor A Litvinov and Akerke K. Tauekel and Sholpan O. Yespenbetova and Alexander R Burilov and Michail A. Pudovik},
title = {Synthesis and Anticancer Evaluation of Novel 7-Aza-Coumarine-3-Carboxamides},
journal = {International Journal of Molecular Sciences},
year = {2023},
volume = {24},
publisher = {MDPI},
month = {jun},
url = {https://doi.org/10.3390/ijms24129927},
number = {12},
pages = {9927},
doi = {10.3390/ijms24129927}
}
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MLA
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Trifonov, Alexey V., et al. “Synthesis and Anticancer Evaluation of Novel 7-Aza-Coumarine-3-Carboxamides.” International Journal of Molecular Sciences, vol. 24, no. 12, Jun. 2023, p. 9927. https://doi.org/10.3390/ijms24129927.
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