Open Access
Inhibition of Topoisomerases by Metal Thiosemicarbazone Complexes
Jiang Xiaohua
1
,
Lauren A. Fielding
2
,
Hunter Davis
3
,
William Carroll
3
,
Edward C Lisic
3
,
Joseph E Deweese
2, 4
2
Department of Biological, Physical and Human Sciences, Freed Hardeman University, Henderson, TN 38340, USA
|
Publication type: Journal Article
Publication date: 2023-07-27
scimago Q1
wos Q1
SJR: 1.273
CiteScore: 9.0
Impact factor: 4.9
ISSN: 16616596, 14220067
PubMed ID:
37569386
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
Topoisomerases, common targets for anti-cancer therapeutics, are crucial enzymes for DNA replication, transcription, and many other aspects of DNA metabolism. The potential anti-cancer effects of thiosemicarbazones (TSC) and metal–TSC complexes have been demonstrated to target several biological processes, including DNA metabolism. Human topoisomerases were discovered among the molecular targets for TSCs, and metal-chelated TSCs specifically displayed significant inhibition of topoisomerase II. The processes by which metal–TSCs or TSCs inhibit topoisomerases are still being studied. In this brief review, we summarize the TSCs and metal–TSCs that inhibit various types of human topoisomerases, and we note some of the key unanswered questions regarding this interesting class of diverse compounds.
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Metrics
14
Total citations:
14
Citations from 2025:
6
(46.15%)
Cite this
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BibTex |
MLA
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GOST
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Jiang Xiaohua et al. Inhibition of Topoisomerases by Metal Thiosemicarbazone Complexes // International Journal of Molecular Sciences. 2023. Vol. 24. No. 15. p. 12010.
GOST all authors (up to 50)
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Jiang Xiaohua, Fielding L. A., Davis H., Carroll W., Lisic E. C., Deweese J. E. Inhibition of Topoisomerases by Metal Thiosemicarbazone Complexes // International Journal of Molecular Sciences. 2023. Vol. 24. No. 15. p. 12010.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/ijms241512010
UR - https://doi.org/10.3390/ijms241512010
TI - Inhibition of Topoisomerases by Metal Thiosemicarbazone Complexes
T2 - International Journal of Molecular Sciences
AU - Jiang Xiaohua
AU - Fielding, Lauren A.
AU - Davis, Hunter
AU - Carroll, William
AU - Lisic, Edward C
AU - Deweese, Joseph E
PY - 2023
DA - 2023/07/27
PB - MDPI
SP - 12010
IS - 15
VL - 24
PMID - 37569386
SN - 1661-6596
SN - 1422-0067
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2023_Jiang Xiaohua,
author = {Jiang Xiaohua and Lauren A. Fielding and Hunter Davis and William Carroll and Edward C Lisic and Joseph E Deweese},
title = {Inhibition of Topoisomerases by Metal Thiosemicarbazone Complexes},
journal = {International Journal of Molecular Sciences},
year = {2023},
volume = {24},
publisher = {MDPI},
month = {jul},
url = {https://doi.org/10.3390/ijms241512010},
number = {15},
pages = {12010},
doi = {10.3390/ijms241512010}
}
Cite this
MLA
Copy
Jiang Xiaohua, et al. “Inhibition of Topoisomerases by Metal Thiosemicarbazone Complexes.” International Journal of Molecular Sciences, vol. 24, no. 15, Jul. 2023, p. 12010. https://doi.org/10.3390/ijms241512010.