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MDPI
International Journal of Molecular Sciences
,  volume 26 ,  issue 1 ,  pages 369

4-Alkyl-4H-thieno[2′,3′:4,5]pyrrolo[2,3-b]quinoxaline Derivatives as New Heterocyclic Analogues of Indolo[2,3-b]quinoxalines: Synthesis and Antitubercular Activity

Gusein A Sadykhov 1, 2
, 
Danila V Belyaev 1, 3
, 
Ekaterina E Khramtsova 4
, 
Diana V. Vakhrusheva 3
, 
S. Yu. Krasnoborova 3
, 
Dmitry V. Dianov 3
, 
Marina G. Pervova 1
, 
Gennady L. Rusinov 1, 3
, 
Egor V. Verbitskiy 1, 2
, 
Valery Charushin 1, 2
1
 
2
 
3
 
4
 
Publication type: Journal Article
Publication date: 2025-01-03
MDPI
scimago Q1
wos Q1
SJR: 1.273
CiteScore: 9.0
Impact factor: 4.9
ISSN: 16616596, 14220067
Abstract

The synthetic approach based on a sequence of Buchwald–Hartwig cross-coupling and annulation through intramolecular oxidative cyclodehydrogenation has been used for the construction of novel 4-alkyl-4H-thieno[2′,3′:4,5]pyrrolo[2,3-b]quinoxaline derivatives. For the first time, these polycyclic compounds were evaluated for antimycobacterial activity, including extensively drug-resistant strains. A reasonable bacteriostatic effect against Mycobacterium tuberculosis H37Rv was demonstrated. A plausible mechanism for antimycobacterial activity of heterocyclic analogues of indolo[2,3-b]quinoxalines has been advanced on the basis of their molecular docking data.

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Sadykhov G. A. et al. 4-Alkyl-4H-thieno[2′,3′:4,5]pyrrolo[2,3-b]quinoxaline Derivatives as New Heterocyclic Analogues of Indolo[2,3-b]quinoxalines: Synthesis and Antitubercular Activity // International Journal of Molecular Sciences. 2025. Vol. 26. No. 1. p. 369.
GOST all authors (up to 50) Copy
Sadykhov G. A., Belyaev D. V., Khramtsova E. E., Vakhrusheva D. V., Krasnoborova S. Y., Dianov D. V., Pervova M. G., Rusinov G. L., Verbitskiy E. V., Charushin V. 4-Alkyl-4H-thieno[2′,3′:4,5]pyrrolo[2,3-b]quinoxaline Derivatives as New Heterocyclic Analogues of Indolo[2,3-b]quinoxalines: Synthesis and Antitubercular Activity // International Journal of Molecular Sciences. 2025. Vol. 26. No. 1. p. 369.
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RIS Copy
TY - JOUR
DO - 10.3390/ijms26010369
UR - https://www.mdpi.com/1422-0067/26/1/369
TI - 4-Alkyl-4H-thieno[2′,3′:4,5]pyrrolo[2,3-b]quinoxaline Derivatives as New Heterocyclic Analogues of Indolo[2,3-b]quinoxalines: Synthesis and Antitubercular Activity
T2 - International Journal of Molecular Sciences
AU - Sadykhov, Gusein A
AU - Belyaev, Danila V
AU - Khramtsova, Ekaterina E
AU - Vakhrusheva, Diana V.
AU - Krasnoborova, S. Yu.
AU - Dianov, Dmitry V.
AU - Pervova, Marina G.
AU - Rusinov, Gennady L.
AU - Verbitskiy, Egor V.
AU - Charushin, Valery
PY - 2025
DA - 2025/01/03
PB - MDPI
SP - 369
IS - 1
VL - 26
SN - 1661-6596
SN - 1422-0067
ER -
BibTex |
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@article{2025_Sadykhov,
author = {Gusein A Sadykhov and Danila V Belyaev and Ekaterina E Khramtsova and Diana V. Vakhrusheva and S. Yu. Krasnoborova and Dmitry V. Dianov and Marina G. Pervova and Gennady L. Rusinov and Egor V. Verbitskiy and Valery Charushin},
title = {4-Alkyl-4H-thieno[2′,3′:4,5]pyrrolo[2,3-b]quinoxaline Derivatives as New Heterocyclic Analogues of Indolo[2,3-b]quinoxalines: Synthesis and Antitubercular Activity},
journal = {International Journal of Molecular Sciences},
year = {2025},
volume = {26},
publisher = {MDPI},
month = {jan},
url = {https://www.mdpi.com/1422-0067/26/1/369},
number = {1},
pages = {369},
doi = {10.3390/ijms26010369}
}
MLA
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Sadykhov, Gusein A., et al. “4-Alkyl-4H-thieno[2′,3′:4,5]pyrrolo[2,3-b]quinoxaline Derivatives as New Heterocyclic Analogues of Indolo[2,3-b]quinoxalines: Synthesis and Antitubercular Activity.” International Journal of Molecular Sciences, vol. 26, no. 1, Jan. 2025, p. 369. https://www.mdpi.com/1422-0067/26/1/369.