Open Access

Journal of Functional Biomaterials, volume 14, issue 4, pages 179

Magnetic Nanoscalpel for the Effective Treatment of Ascites Tumors

Zamay Tatiana ^{1, 2}

Zamay Sergey ¹

Luzan Natalia ^{1, 2}

Fedotovskaya Victoriya ²

Masyugin Albert ³

Zelenov Fyodor ³

Koshmanova Anastasia A. ^{1, 2}

Nikolaeva Elena ^{1, 2}

Kirichenko Daria ²

Veprintsev Dmitry ¹

Kolovskaya Olga ^{1, 2}

Shchugoreva Irina ^{1, 2}

Zamay Galina ^{1, 2}

Lapin Ivan N. ⁴

Lukyanenko Anna ⁵

Borus Andrey ⁵

Sukhachev Alexander ⁵

Volochaev Mikhail ⁵

Lukyanenko Kirill A. ^{1, 2}

Shabanov Alexandr ¹

Zabluda Vladimir ⁵

Zhizhchenko Alexey ^{6, 7}

Kuchmizhak Aleksandr ^{6, 7}

Sokolov I E ⁵

Narodov Andrey ²

Prokopenko Vladimir ⁸

Galeev Rinat ³

Svetlichnyi Valery ⁴

Kichkailo Anna ^{1, 2}

Hide authors affiliations Show authors affiliations: 8 affiliations

Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch, Russian Academy of Sciences, Krasnoyarsk 660036, Russia |

Laboratory for Biomolecular and Medical Technologies, Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk 660022, Russia |

JSC «NPP «Radiosviaz», Krasnoyarsk 660021, Russia |

⁴

Laboratory of Advanced Materials and Technology, Siberian Physical Technical Institute, Tomsk State University, Tomsk 634050, Russia |

⁵

L.V. Kirensky Institute of Physics, Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk 660036, Russia |

⁶

Far Eastern Federal University, Vladivostok 690950, Russia |

⁷

Institute of Automation and Control Processes (IACP), Far Eastern Branch of the Russian Academy of Science, Vladivostok 690041, Russia |

⁸

V.P. Astafiev Krasnoyarsk State Pedagogical University, Krasnoyarsk 660049, Russia |

Publication type: Journal Article

Publication date: 2023-03-24

Multidisciplinary Digital Publishing Institute (MDPI)

Journal: Journal of Functional Biomaterials

Quartile SCImago

Quartile WOS

Impact factor: 4.8

ISSN: 20794983

DOI: 10.3390/jfb14040179

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Biomaterials

Biomedical Engineering

Abstract

One of the promising novel methods for radical tumor resection at a single-cell level is magneto-mechanical microsurgery (MMM) with magnetic nano- or microdisks modified with cancer-recognizing molecules. A low-frequency alternating magnetic field (AMF) remotely drives and controls the procedure. Here, we present characterization and application of magnetic nanodisks (MNDs) as a surgical instrument (“smart nanoscalpel”) at a single-cell level. MNDs with a quasi-dipole three-layer structure (Au/Ni/Au) and DNA aptamer AS42 (AS42-MNDs) on the surface converted magnetic moment into mechanical and destroyed tumor cells. The effectiveness of MMM was analyzed on Ehrlich ascites carcinoma (EAC) cells in vitro and in vivo using sine and square-shaped AMF with frequencies from 1 to 50 Hz with 0.1 to 1 duty-cycle parameters. MMM with the “Nanoscalpel” in a sine-shaped 20 Hz AMF, a rectangular-shaped 10 Hz AMF, and a 0.5 duty cycle was the most effective. A sine-shaped field caused apoptosis, whereas a rectangular-shaped field caused necrosis. Four sessions of MMM with AS42-MNDs significantly reduced the number of cells in the tumor. In contrast, ascites tumors continued to grow in groups of mice and mice treated with MNDs with nonspecific oligonucleotide NO-MND. Thus, applying a “smart nanoscalpel” is practical for the microsurgery of malignant neoplasms.

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Zamay T. et al. Magnetic Nanoscalpel for the Effective Treatment of Ascites Tumors // Journal of Functional Biomaterials. 2023. Vol. 14. No. 4. p. 179.

GOST all authors (up to 50) Copy

Zamay T., Zamay S., Luzan N., Fedotovskaya V., Masyugin A., Zelenov F., Koshmanova A. A., Nikolaeva E., Kirichenko D., Veprintsev D., Kolovskaya O., Shchugoreva I., Zamay G., Lapin I. N., Lukyanenko A., Borus A., Sukhachev A., Volochaev M., Lukyanenko K. A., Shabanov A., Zabluda V., Zhizhchenko A., Kuchmizhak A., Sokolov I. E., Narodov A., Prokopenko V., Galeev R., Svetlichnyi V., Kichkailo A. Magnetic Nanoscalpel for the Effective Treatment of Ascites Tumors // Journal of Functional Biomaterials. 2023. Vol. 14. No. 4. p. 179.

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RIS Copy

TY - JOUR

DO - 10.3390/jfb14040179

UR - https://doi.org/10.3390%2Fjfb14040179

TI - Magnetic Nanoscalpel for the Effective Treatment of Ascites Tumors

T2 - Journal of Functional Biomaterials

AU - Zamay, Tatiana

AU - Zamay, Sergey

AU - Luzan, Natalia

AU - Fedotovskaya, Victoriya

AU - Masyugin, Albert

AU - Zelenov, Fyodor

AU - Koshmanova, Anastasia A.

AU - Nikolaeva, Elena

AU - Kirichenko, Daria

AU - Veprintsev, Dmitry

AU - Kolovskaya, Olga

AU - Shchugoreva, Irina

AU - Zamay, Galina

AU - Lapin, Ivan N.

AU - Lukyanenko, Anna

AU - Borus, Andrey

AU - Sukhachev, Alexander

AU - Volochaev, Mikhail

AU - Lukyanenko, Kirill A.

AU - Shabanov, Alexandr

AU - Zabluda, Vladimir

AU - Zhizhchenko, Alexey

AU - Kuchmizhak, Aleksandr

AU - Sokolov, I E

AU - Narodov, Andrey

AU - Prokopenko, Vladimir

AU - Galeev, Rinat

AU - Svetlichnyi, Valery

AU - Kichkailo, Anna

PY - 2023

DA - 2023/03/24 00:00:00

PB - Multidisciplinary Digital Publishing Institute (MDPI)

SP - 179

IS - 4

VL - 14

SN - 2079-4983

ER -

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@article{2023_Zamay,

author = {Tatiana Zamay and Sergey Zamay and Natalia Luzan and Victoriya Fedotovskaya and Albert Masyugin and Fyodor Zelenov and Anastasia A. Koshmanova and Elena Nikolaeva and Daria Kirichenko and Dmitry Veprintsev and Olga Kolovskaya and Irina Shchugoreva and Galina Zamay and Ivan N. Lapin and Anna Lukyanenko and Andrey Borus and Alexander Sukhachev and Mikhail Volochaev and Kirill A. Lukyanenko and Alexandr Shabanov and Vladimir Zabluda and Alexey Zhizhchenko and Aleksandr Kuchmizhak and I E Sokolov and Andrey Narodov and Vladimir Prokopenko and Rinat Galeev and Valery Svetlichnyi and Anna Kichkailo},

title = {Magnetic Nanoscalpel for the Effective Treatment of Ascites Tumors},

journal = {Journal of Functional Biomaterials},

year = {2023},

volume = {14},

publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},

month = {mar},

url = {https://doi.org/10.3390%2Fjfb14040179},

number = {4},

pages = {179},

doi = {10.3390/jfb14040179}

}

MLA

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MLA Copy

Zamay, Tatiana, et al. “Magnetic Nanoscalpel for the Effective Treatment of Ascites Tumors.” Journal of Functional Biomaterials, vol. 14, no. 4, Mar. 2023, p. 179. https://doi.org/10.3390%2Fjfb14040179.

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