Open Access
Journal of Personalized Medicine, volume 12, issue 3, pages 399
4-Hydroxyphenyllactic Acid in Cerebrospinal Fluid as a Possible Marker of Post-Neurosurgical Meningitis: Retrospective Study
Alisa K. Pautova
1
,
Anastasiia Yu Meglei
1
,
Ekaterina A. Chernevskaya
1
,
Irina A Alexandrova
2
,
Natalia V. Beloborodova
1
Publication type: Journal Article
Publication date: 2022-03-04
Journal:
Journal of Personalized Medicine
Quartile SCImago
Q2
Quartile WOS
—
Impact factor: —
ISSN: 20754426
Medicine (miscellaneous)
Abstract
The search for new potential biomarkers for the diagnostics of post-neurosurgical bacterial meningitis is required because of the difficulties in its early verification using results of the routine laboratory and biochemical analyses of the cerebrospinal fluid (CSF). The goal of the study was to determine the contents of the aromatic metabolites and biomarkers in the CSF samples of the post-neurosurgical patients (n = 82) and their potential diagnostical significance for the evaluation of the risk of post-neurosurgical meningitis. Patients with signs of post-neurosurgical meningitis (n = 30) had lower median values of glucose and higher values of cell count, neutrophils, lactate, protein, 3-(4-hydroxyphenyl)lactic acid (p-HPhLA), and interleukin-6 (IL-6) than patients without signs of post-neurosurgical meningitis (n = 52). ROC analysis for IL-6 and p-HPhLA resulted in 0.785 and 0.734 values of the area under the ROC curve, with sensitivity 96.30 and 66.67%; specificity 54.17 and 82.69%, respectively. IL-6 should be considered as a non-specific biomarker, in contrast to the microbial metabolite p-HPhLA. If the concentration of p-HPhLA was more or equal to 0.9 µmol/L, the risk of bacterial complications was 9.6 times higher. p-HPhLA is a promising marker for the prognosis of post-neurosurgical meningitis, and its determination on a larger group of post-neurosurgical patients can subsequently prove its diagnostic significance for the verification of CNS infections.
Top-30
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Neurosurgery
2 publications, 33.33%
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Molecules
1 publication, 16.67%
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1 publication, 16.67%
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1 publication, 16.67%
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Citations by publishers
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Wolters Kluwer Health
2 publications, 33.33%
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 16.67%
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Springer Nature
1 publication, 16.67%
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1 publication, 16.67%
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- We do not take into account publications without a DOI.
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- Statistics recalculated weekly.
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Pautova A. K. et al. 4-Hydroxyphenyllactic Acid in Cerebrospinal Fluid as a Possible Marker of Post-Neurosurgical Meningitis: Retrospective Study // Journal of Personalized Medicine. 2022. Vol. 12. No. 3. p. 399.
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Pautova A. K., Meglei A. Yu., Chernevskaya E. A., Alexandrova I. A., Beloborodova N. V. 4-Hydroxyphenyllactic Acid in Cerebrospinal Fluid as a Possible Marker of Post-Neurosurgical Meningitis: Retrospective Study // Journal of Personalized Medicine. 2022. Vol. 12. No. 3. p. 399.
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TY - JOUR
DO - 10.3390/jpm12030399
UR - https://doi.org/10.3390/jpm12030399
TI - 4-Hydroxyphenyllactic Acid in Cerebrospinal Fluid as a Possible Marker of Post-Neurosurgical Meningitis: Retrospective Study
T2 - Journal of Personalized Medicine
AU - Alexandrova, Irina A
AU - Pautova, Alisa K.
AU - Meglei, Anastasiia Yu
AU - Chernevskaya, Ekaterina A.
AU - Beloborodova, Natalia V.
PY - 2022
DA - 2022/03/04 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 399
IS - 3
VL - 12
SN - 2075-4426
ER -
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@article{2022_Pautova,
author = {Irina A Alexandrova and Alisa K. Pautova and Anastasiia Yu Meglei and Ekaterina A. Chernevskaya and Natalia V. Beloborodova},
title = {4-Hydroxyphenyllactic Acid in Cerebrospinal Fluid as a Possible Marker of Post-Neurosurgical Meningitis: Retrospective Study},
journal = {Journal of Personalized Medicine},
year = {2022},
volume = {12},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {mar},
url = {https://doi.org/10.3390/jpm12030399},
number = {3},
pages = {399},
doi = {10.3390/jpm12030399}
}
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MLA
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Pautova, Alisa K., et al. “4-Hydroxyphenyllactic Acid in Cerebrospinal Fluid as a Possible Marker of Post-Neurosurgical Meningitis: Retrospective Study.” Journal of Personalized Medicine, vol. 12, no. 3, Mar. 2022, p. 399. https://doi.org/10.3390/jpm12030399.