5-(4-Nitrophenyl)furan-2-carboxylic Acid

Matteo Mori ¹

Andrea Tresoldi ¹

Stefania Villa ¹

Giulia Cazzaniga ¹

M. Bellinzoni ²

Fiorella Meneghetti ¹

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Department of Pharmaceutical Sciences, University of Milan, Via L. Mangiagalli 25, 20133 Milano, Italy |

Unité de Microbiologie Structurale, Institut Pasteur, CNRS, Université de Paris, F-75015 Paris, France |

Publication type: Journal Article

Publication date: 2022-12-02

MDPI

Journal: MolBank

scimago Q4

wos Q4

SJR: 0.150

CiteScore: 0.7

Impact factor: 0.6

ISSN: 14228599

DOI: 10.3390/m1515

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Organic Chemistry

Biochemistry

Physical and Theoretical Chemistry

Abstract

The ever-evolving research in the field of antitubercular agents has led to the identification of several new potential drug classes. Among them, 5-phenyl-furan-2-carboxylic acids have emerged as innovative potential therapeutics, targeting iron acquisition in mycobacterial species. In our efforts to characterize the molecular interactions between these compounds and their protein target (MbtI from M. tuberculosis) by means of co-crystallization experiments, we unexpectedly obtained the structure of 5-(4-nitrophenyl)furan-2-carboxylic acid (1). Herein, we describe the preparation of the compound and its analysis by 1H NMR, 13C NMR, HRMS, and SC-XRD.