Open Access
Synthesis and Antiproliferative Activity of Triazoles Based on 2-Azabicycloalkanes
Publication type: Journal Article
Publication date: 2021-04-18
PubMed ID:
33919613
General Materials Science
Abstract
A library of 21 novel chiral 1,2,3-triazole-based 2-azabicycloalkane conjugates was designed and synthesized using the copper(I)-catalyzed click reaction. The obtained hybrids were assessed for their antiproliferative potency against three selected human cancer cell lines: Hs294T (melanoma), MIA PaCa-2 (pancreas tumor) and NCI-H1581 (lung tumor). The majority of the synthesized compounds demonstrated moderate to potent activity, and some of them appeared more selective than cisplatin, with selectivity index exceeding 9.
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Metrics
9
Total citations:
9
Citations from 2024:
6
(66.66%)
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GOST
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Steppeler F. et al. Synthesis and Antiproliferative Activity of Triazoles Based on 2-Azabicycloalkanes // Materials. 2021. Vol. 14. No. 8. p. 2039.
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Steppeler F., Kłopotowska D., Wietrzyk J., Wojaczyńska E. Synthesis and Antiproliferative Activity of Triazoles Based on 2-Azabicycloalkanes // Materials. 2021. Vol. 14. No. 8. p. 2039.
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RIS
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TY - JOUR
DO - 10.3390/ma14082039
UR - https://doi.org/10.3390/ma14082039
TI - Synthesis and Antiproliferative Activity of Triazoles Based on 2-Azabicycloalkanes
T2 - Materials
AU - Steppeler, Franz
AU - Kłopotowska, Dagmara
AU - Wietrzyk, Joanna
AU - Wojaczyńska, Elżbieta
PY - 2021
DA - 2021/04/18
PB - MDPI
SP - 2039
IS - 8
VL - 14
PMID - 33919613
SN - 1996-1944
ER -
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BibTex (up to 50 authors)
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@article{2021_Steppeler,
author = {Franz Steppeler and Dagmara Kłopotowska and Joanna Wietrzyk and Elżbieta Wojaczyńska},
title = {Synthesis and Antiproliferative Activity of Triazoles Based on 2-Azabicycloalkanes},
journal = {Materials},
year = {2021},
volume = {14},
publisher = {MDPI},
month = {apr},
url = {https://doi.org/10.3390/ma14082039},
number = {8},
pages = {2039},
doi = {10.3390/ma14082039}
}
Cite this
MLA
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Steppeler, Franz, et al. “Synthesis and Antiproliferative Activity of Triazoles Based on 2-Azabicycloalkanes.” Materials, vol. 14, no. 8, Apr. 2021, p. 2039. https://doi.org/10.3390/ma14082039.