Open Access
Materials, volume 15, issue 13, pages 4643
UMAOH Calcium Phosphate Coatings Designed for Drug Delivery: Vancomycin, 5-Fluorouracil, Interferon α-2b Case
Kazantseva Ekaterina A
1, 2
,
Lozhkomoev Aleksandr
1, 3
,
Kazantsev Sergei O
3
,
Bakina Olga V.
3
,
Mishina Marina V
4
,
Zima Anastasia P
5
,
Khlusov I. A.
1, 7
,
2
Publication type: Journal Article
Publication date: 2022-07-01
PubMed ID:
35806777
General Materials Science
Abstract
Drug delivery systems based on calcium phosphate (CaP) coatings have been recently recognized as beneficial drug delivery systems in complex cases of bone diseases for admission of drugs in the localized area, simultaneously inducing osteoinduction because of the bioavailable Ca and P ions. However, micro-arc oxidation (MAO) deposition of CaP does not allow for the formation of a coating with sufficient interconnected porosity for drug delivery purposes. Here, we report on the method to deposit CaP-based coatings using a new hybrid ultrasound-assisted MAO (UMAOH) method for deposition of coatings for drug delivery that could carry various types of drugs, such as cytostatic, antibacterial, or immunomodulatory compositions. Application of UMAOH resulted in coatings with an Ra roughness equal to 3.5 µm, a thickness of 50–55 µm, and a combination of high values of internal and surface porosity, 39 and 28%, respectively. The coating is represented by the monetite phase that is distributed in the matrix of amorphous CaP. Optimal conditions of coating deposition have been determined and used for drug delivery by impregnation with Vancomycin, 5-Fluorouracil, and Interferon-α-2b. Cytotoxicity and antimicrobial activity of the manufactured drug-carrying coatings have been studied using the three different cell lines and methicillin-resistant S. aureus.
Citations by journals
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1
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Materials
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Materials
1 publication, 16.67%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
1 publication, 16.67%
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Journal of Composites Science
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Journal of Composites Science
1 publication, 16.67%
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Materials Today Bio
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Materials Today Bio
1 publication, 16.67%
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AIP Conference Proceedings
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AIP Conference Proceedings
1 publication, 16.67%
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Polymers
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Polymers
1 publication, 16.67%
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1
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Citations by publishers
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1
2
3
4
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
4 publications, 66.67%
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Elsevier
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Elsevier
1 publication, 16.67%
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American Institute of Physics (AIP)
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American Institute of Physics (AIP)
1 publication, 16.67%
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1
2
3
4
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Prosolov K. A. et al. UMAOH Calcium Phosphate Coatings Designed for Drug Delivery: Vancomycin, 5-Fluorouracil, Interferon α-2b Case // Materials. 2022. Vol. 15. No. 13. p. 4643.
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Prosolov K. A., Komarova E. G., Kazantseva E. A., Lozhkomoev A., Kazantsev S. O., Bakina O. V., Mishina M. V., Zima A. P., Krivoshchekov S. V., Khlusov I. A., Sharkeev Y. P. UMAOH Calcium Phosphate Coatings Designed for Drug Delivery: Vancomycin, 5-Fluorouracil, Interferon α-2b Case // Materials. 2022. Vol. 15. No. 13. p. 4643.
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TY - JOUR
DO - 10.3390/ma15134643
UR - https://doi.org/10.3390%2Fma15134643
TI - UMAOH Calcium Phosphate Coatings Designed for Drug Delivery: Vancomycin, 5-Fluorouracil, Interferon α-2b Case
T2 - Materials
AU - Kazantseva, Ekaterina A
AU - Kazantsev, Sergei O
AU - Bakina, Olga V.
AU - Mishina, Marina V
AU - Zima, Anastasia P
AU - Prosolov, Konstantin A
AU - Komarova, Ekaterina G
AU - Lozhkomoev, Aleksandr
AU - Krivoshchekov, Sergei V
AU - Khlusov, I. A.
AU - Sharkeev, Yurii P
PY - 2022
DA - 2022/07/01 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 4643
IS - 13
VL - 15
PMID - 35806777
SN - 1996-1944
ER -
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@article{2022_Prosolov,
author = {Ekaterina A Kazantseva and Sergei O Kazantsev and Olga V. Bakina and Marina V Mishina and Anastasia P Zima and Konstantin A Prosolov and Ekaterina G Komarova and Aleksandr Lozhkomoev and Sergei V Krivoshchekov and I. A. Khlusov and Yurii P Sharkeev},
title = {UMAOH Calcium Phosphate Coatings Designed for Drug Delivery: Vancomycin, 5-Fluorouracil, Interferon α-2b Case},
journal = {Materials},
year = {2022},
volume = {15},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jul},
url = {https://doi.org/10.3390%2Fma15134643},
number = {13},
pages = {4643},
doi = {10.3390/ma15134643}
}
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Prosolov, Konstantin A., et al. “UMAOH Calcium Phosphate Coatings Designed for Drug Delivery: Vancomycin, 5-Fluorouracil, Interferon α-2b Case.” Materials, vol. 15, no. 13, Jul. 2022, p. 4643. https://doi.org/10.3390%2Fma15134643.