Open Access
Metabolites, volume 11, issue 2, pages 122
Host-Microbiome Interactions Mediated by Phenolic Metabolites in Chronically Critically Ill Patients
Ekaterina A. Chernevskaya
1
,
Natalia S Klimenko
2, 3
,
Alisa Pautova
1
,
Irina Buyakova
1
,
Alexander Tyakht
2, 3
,
Natalia V. Beloborodova
1
2
Atlas Biomed Group—Knomics LLC, 31 Malaya Nikitskaya Str., 121069 Moscow, Russia
|
Publication type: Journal Article
Publication date: 2021-02-20
Journal:
Metabolites
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 4.1
ISSN: 22181989, 22181989
Biochemistry
Molecular Biology
Endocrinology, Diabetes and Metabolism
Abstract
The community structure and metabolic potential of gut microbiome is not well investigated, especially in chronically critically ill patients with prolonged dependence on support systems after severe brain disorders. Microbial phenolic metabolites can target the brain function by the direct and indirect modulation of inflammation. The aim of this study was to investigate the features of the gut microbiota and profile of certain metabolites in the progression and reversibility of neurological disorders in chronically critically ill patients. Fecal samples were collected in dynamics from such patients (n = 44) and analyzed using 16S rRNA sequencing. Serum microbial and mitochondrial metabolites were measured by GC-MS and compared with the biomarkers and clinical neurological scores. The identified associations between specific bacterial taxa in fecal samples, neurological status and serum levels of metabolites suggest that impacts on specific members of the gut microbiota and their metabolism might be a promising tool for regulating brain function in future.
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Citations by publishers
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1 publication, 7.69%
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4
5
6
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Chernevskaya E. A. et al. Host-Microbiome Interactions Mediated by Phenolic Metabolites in Chronically Critically Ill Patients // Metabolites. 2021. Vol. 11. No. 2. p. 122.
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Chernevskaya E. A., Klimenko N. S., Pautova A., Buyakova I., Tyakht A., Beloborodova N. V. Host-Microbiome Interactions Mediated by Phenolic Metabolites in Chronically Critically Ill Patients // Metabolites. 2021. Vol. 11. No. 2. p. 122.
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TY - JOUR
DO - 10.3390/metabo11020122
UR - https://doi.org/10.3390/metabo11020122
TI - Host-Microbiome Interactions Mediated by Phenolic Metabolites in Chronically Critically Ill Patients
T2 - Metabolites
AU - Pautova, Alisa
AU - Buyakova, Irina
AU - Chernevskaya, Ekaterina A.
AU - Klimenko, Natalia S
AU - Tyakht, Alexander
AU - Beloborodova, Natalia V.
PY - 2021
DA - 2021/02/20 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 122
IS - 2
VL - 11
SN - 2218-1989
SN - 2218-1989
ER -
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@article{2021_Chernevskaya,
author = {Alisa Pautova and Irina Buyakova and Ekaterina A. Chernevskaya and Natalia S Klimenko and Alexander Tyakht and Natalia V. Beloborodova},
title = {Host-Microbiome Interactions Mediated by Phenolic Metabolites in Chronically Critically Ill Patients},
journal = {Metabolites},
year = {2021},
volume = {11},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {feb},
url = {https://doi.org/10.3390/metabo11020122},
number = {2},
pages = {122},
doi = {10.3390/metabo11020122}
}
Cite this
MLA
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Chernevskaya, Ekaterina A., et al. “Host-Microbiome Interactions Mediated by Phenolic Metabolites in Chronically Critically Ill Patients.” Metabolites, vol. 11, no. 2, Feb. 2021, p. 122. https://doi.org/10.3390/metabo11020122.