Open Access
Open access

Single Red Blood Cell Hydrodynamic Traps via the Generative Design

Grigorev G.V., Nikitin N.O., Hvatov A., Kalyuzhnaya A.V., Lebedev A.V., Wang X., Qian X., Maksimov G.V., Lin L.
Тип документаJournal Article
Дата публикации2022-03-01
Название журналаMicromachines
ИздательMultidisciplinary Digital Publishing Institute (MDPI)
Квартиль по SCImagoQ2
Квартиль по Web of ScienceQ2
Импакт-фактор 20213.52
Electrical and Electronic Engineering
Mechanical Engineering
Control and Systems Engineering
Краткое описание
This paper describes a generative design methodology for a micro hydrodynamic single-RBC (red blood cell) trap for applications in microfluidics-based single-cell analysis. One key challenge in single-cell microfluidic traps is to achieve desired through-slit flowrates to trap cells under implicit constraints. In this work, the cell-trapping design with validation from experimental data has been developed by the generative design methodology with an evolutionary algorithm. L-shaped trapping slits have been generated iteratively for the optimal geometries to trap living-cells suspended in flow channels. Without using the generative design, the slits have low flow velocities incapable of trapping single cells. After a search with 30,000 solutions, the optimized geometry was found to increase the through-slit velocities by 49%. Fabricated and experimentally tested prototypes have achieved 4 out of 4 trapping efficiency of RBCs. This evolutionary algorithm and trapping design can be applied to cells of various sizes.
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1. Grigorev G. V. и др. Single Red Blood Cell Hydrodynamic Traps via the Generative Design // Micromachines. 2022. Т. 13. № 3. С. 367.


DO - 10.3390/mi13030367

UR -

TI - Single Red Blood Cell Hydrodynamic Traps via the Generative Design

T2 - Micromachines

AU - Grigorev, Georgii V.

AU - Nikitin, Nikolay O.

AU - Hvatov, Alexander

AU - Kalyuzhnaya, Anna V.

AU - Lebedev, Alexander V.

AU - Wang, Xiaohao

AU - Qian, Xiang

AU - Maksimov, Georgii V.

AU - Lin, Liwei

PY - 2022

DA - 2022/02/26


SP - 367

IS - 3

VL - 13

SN - 2072-666X

ER -

BibTex |


doi = {10.3390/mi13030367},

url = {},

year = 2022,

month = {feb},

publisher = {{MDPI} {AG}},

volume = {13},

number = {3},

pages = {367},

author = {Georgii V. Grigorev and Nikolay O. Nikitin and Alexander Hvatov and Anna V. Kalyuzhnaya and Alexander V. Lebedev and Xiaohao Wang and Xiang Qian and Georgii V. Maksimov and Liwei Lin},

title = {Single Red Blood Cell Hydrodynamic Traps via the Generative Design},

journal = {Micromachines}


Grigorev, Georgii V., et al. “Single Red Blood Cell Hydrodynamic Traps via the Generative Design.” Micromachines, vol. 13, no. 3, Feb. 2022, p. 367. Crossref,