Open Access
Micromachines, volume 13, issue 3, pages 367
Single Red Blood Cell Hydrodynamic Traps via the Generative Design
Grigorev Georgii V
1, 2
,
Hvatov Alexander
3
,
Lebedev Alexander V.
4
,
Wang Xiaohao
5
,
Qian Xiang
5
,
Maksimov Georgy V.
6, 7
,
Lin LiWei
2
2
Mechanical Department, University of California in Berkeley, Berkeley, CA 94703, USA
|
Publication type: Journal Article
Publication date: 2022-02-26
PubMed ID:
35334659
Electrical and Electronic Engineering
Mechanical Engineering
Control and Systems Engineering
Abstract
This paper describes a generative design methodology for a micro hydrodynamic single-RBC (red blood cell) trap for applications in microfluidics-based single-cell analysis. One key challenge in single-cell microfluidic traps is to achieve desired through-slit flowrates to trap cells under implicit constraints. In this work, the cell-trapping design with validation from experimental data has been developed by the generative design methodology with an evolutionary algorithm. L-shaped trapping slits have been generated iteratively for the optimal geometries to trap living-cells suspended in flow channels. Without using the generative design, the slits have low flow velocities incapable of trapping single cells. After a search with 30,000 solutions, the optimized geometry was found to increase the through-slit velocities by 49%. Fabricated and experimentally tested prototypes have achieved 4 out of 4 trapping efficiency of RBCs. This evolutionary algorithm and trapping design can be applied to cells of various sizes.
Citations by journals
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1
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Engineering Applications of Artificial Intelligence
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Engineering Applications of Artificial Intelligence
1 publication, 33.33%
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Micromachines
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Micromachines
1 publication, 33.33%
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Biosensors
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Biosensors
1 publication, 33.33%
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1
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Citations by publishers
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1
2
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 66.67%
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Elsevier
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Elsevier
1 publication, 33.33%
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1
2
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Grigorev G. V. et al. Single Red Blood Cell Hydrodynamic Traps via the Generative Design // Micromachines. 2022. Vol. 13. No. 3. p. 367.
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Grigorev G. V., Nikitin N. O., Hvatov A., Kalyuzhnaya A. V., Lebedev A. V., Wang X., Qian X., Maksimov G. V., Lin L. Single Red Blood Cell Hydrodynamic Traps via the Generative Design // Micromachines. 2022. Vol. 13. No. 3. p. 367.
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RIS
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TY - JOUR
DO - 10.3390/mi13030367
UR - https://doi.org/10.3390%2Fmi13030367
TI - Single Red Blood Cell Hydrodynamic Traps via the Generative Design
T2 - Micromachines
AU - Grigorev, Georgii V
AU - Lebedev, Alexander V.
AU - Wang, Xiaohao
AU - Lin, LiWei
AU - Kalyuzhnaya, Anna V
AU - Nikitin, Nikolay O
AU - Hvatov, Alexander
AU - Qian, Xiang
AU - Maksimov, Georgy V.
PY - 2022
DA - 2022/02/26 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 367
IS - 3
VL - 13
PMID - 35334659
SN - 2072-666X
ER -
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@article{2022_Grigorev,
author = {Georgii V Grigorev and Alexander V. Lebedev and Xiaohao Wang and LiWei Lin and Anna V Kalyuzhnaya and Nikolay O Nikitin and Alexander Hvatov and Xiang Qian and Georgy V. Maksimov},
title = {Single Red Blood Cell Hydrodynamic Traps via the Generative Design},
journal = {Micromachines},
year = {2022},
volume = {13},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {feb},
url = {https://doi.org/10.3390%2Fmi13030367},
number = {3},
pages = {367},
doi = {10.3390/mi13030367}
}
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MLA
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Grigorev, Georgii V., et al. “Single Red Blood Cell Hydrodynamic Traps via the Generative Design.” Micromachines, vol. 13, no. 3, Feb. 2022, p. 367. https://doi.org/10.3390%2Fmi13030367.