Open Access
Microorganisms, volume 10, issue 5, pages 989
Exploring the Diversity and Antibacterial Potentiality of Cultivable Actinobacteria from the Soil of the Saxaul Forest in Southern Gobi Desert in Mongolia
2
The Institute of Biology, Mongolian Academy of Sciences, Ulaanbaatar 13330, Mongolia
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Publication type: Journal Article
Publication date: 2022-05-09
Microbiology (medical)
Microbiology
Virology
Abstract
Saxaul (Haloxylon ammodendron) is the most widespread plant community in the Gobi Desert in Mongolia, which plays important roles in wind control, sand fixation and water conservation. Investigations of soil-derived actinobacteria inhabiting in the saxaul forest in Gobi Desert in Mongolia have been scarce. In this study, biodiversity of culturable actinobacteria isolated from soil of the saxaul forest in Southern Gobi Aimak (Southern Gobi Province) of Mongolia was characterized and their potential to produce compounds with antibacterial activities was assessed. A total of 172 actinobacterial strains were recovered by culture-based approaches and were phylogenetically affiliated into 22 genera in 13 families of seven orders. Forty-nine actinobacterial isolates were selected to evaluate the antibacterial activities and their underlying mechanism of action was screened by means of a dual-fluorescent reporter assay (pDualrep2). Twenty-three isolates exhibited antagonistic activity against at least one of the tested pathogens, of which two Streptomyces strains can attenuate protein translation by ribosome stalling. Combinational strategies based on modern metabolomics, including bioassay-guided thin-layer chromatography (TLC), UPLC-QTOF-MS/MS based structural annotation and enhanced molecular networking successfully annotated chloramphenicol, althiomycin and granaticin and their derivatives as the antibacterial compounds from extracts in three Streptomyces strains, respectively. This work demonstrates that UPLC-MS/MS-based structural identification and enhanced molecular networking are effective strategies to rapidly illuminate the bioactive chemicals in the microbial extracts. Meanwhile, our results show that the saxaul forest in Mongolia Gobi Desert is a prospective source for discovering novel actinobacteria and biologically active compounds.
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Liu S. W. et al. Exploring the Diversity and Antibacterial Potentiality of Cultivable Actinobacteria from the Soil of the Saxaul Forest in Southern Gobi Desert in Mongolia // Microorganisms. 2022. Vol. 10. No. 5. p. 989.
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Liu S. W., Jadambaa N., Nikandrova A. A., Osterman I. A., Sun C. Exploring the Diversity and Antibacterial Potentiality of Cultivable Actinobacteria from the Soil of the Saxaul Forest in Southern Gobi Desert in Mongolia // Microorganisms. 2022. Vol. 10. No. 5. p. 989.
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TY - JOUR
DO - 10.3390/microorganisms10050989
UR - https://doi.org/10.3390%2Fmicroorganisms10050989
TI - Exploring the Diversity and Antibacterial Potentiality of Cultivable Actinobacteria from the Soil of the Saxaul Forest in Southern Gobi Desert in Mongolia
T2 - Microorganisms
AU - Jadambaa, Norovsuren
AU - Liu, Shao Wei
AU - Nikandrova, Arina A
AU - Osterman, Ilya A
AU - Sun, Chenghang
PY - 2022
DA - 2022/05/09 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 989
IS - 5
VL - 10
SN - 2076-2607
ER -
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@article{2022_Liu,
author = {Norovsuren Jadambaa and Shao Wei Liu and Arina A Nikandrova and Ilya A Osterman and Chenghang Sun},
title = {Exploring the Diversity and Antibacterial Potentiality of Cultivable Actinobacteria from the Soil of the Saxaul Forest in Southern Gobi Desert in Mongolia},
journal = {Microorganisms},
year = {2022},
volume = {10},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {may},
url = {https://doi.org/10.3390%2Fmicroorganisms10050989},
number = {5},
pages = {989},
doi = {10.3390/microorganisms10050989}
}
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Liu, Shao Wei, et al. “Exploring the Diversity and Antibacterial Potentiality of Cultivable Actinobacteria from the Soil of the Saxaul Forest in Southern Gobi Desert in Mongolia.” Microorganisms, vol. 10, no. 5, May. 2022, p. 989. https://doi.org/10.3390%2Fmicroorganisms10050989.