Open Access
Open access
Microorganisms, volume 10, issue 11, pages 2293

Probiotic Therapy with Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis Results in Infarct Size Limitation in Rats with Obesity and Chemically Induced Colitis

Borshchev Yury Y 1
Burovenko Inessa Y 1
Karaseva Alena B 2
Minasian Sarkis M 3
Protsak Egor S 1
Borshchev Victor Y 4
Semenova Natalia Y 5
Borshcheva Olga V 1
Suvorov Alexander N 2, 6
Galagudza Michael M. 3, 4
Publication typeJournal Article
Publication date2022-11-18
Journal: Microorganisms
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor4.5
ISSN20762607
Microbiology (medical)
Microbiology
Virology
Abstract

In this study, we investigated the effect of three different probiotics, namely, a combination of Lactobacillus acidophilus (LA–5) and Bifidobacterium animalis subsp. lactis (BB–12), Saccharomyces boulardii, and Enterococcus faecium L3 on myocardial infarct size in rats with diet-induced obesity (DIO) and chemically-induced colitis (CIC). Potential associations between the effects of probiotics on myocardial ischemia-reperfusion injury and gut microbiome patterns as well as the serum levels of pro- and anti-inflammatory cytokines, lipopolysaccharide, and short chain fatty acids were also studied. Intragastric administration of lyophilized Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis at a dose of 1.2 × 108 CFU/mL for 15 days resulted in myocardial infarct size reduction in rats with DIO, CIC, and antibiotic-induced dysbiosis. This cardioprotective effect was associated with specific changes in cytokine concentrations, namely reduced levels of IL–1β, TNF–α, IL–2, and IL–8. At the same time, the use of Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis was accompanied by a significant reduction in lipopolysaccharide level, suggesting normalization of intestinal epithelial barrier permeability. However, the cardioprotective effect of Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis is not secondary to improved healing of the intestinal mucosa in CIC, as evidenced by the lack of difference in histopathological scores.

Citations by journals

1
Probiotics and Antimicrobial Proteins
Probiotics and Antimicrobial Proteins, 1, 25%
Probiotics and Antimicrobial Proteins
1 publication, 25%
The Siberian Journal of Clinical and Experimental Medicine
The Siberian Journal of Clinical and Experimental Medicine, 1, 25%
The Siberian Journal of Clinical and Experimental Medicine
1 publication, 25%
Journal of Evolutionary Biochemistry and Physiology
Journal of Evolutionary Biochemistry and Physiology, 1, 25%
Journal of Evolutionary Biochemistry and Physiology
1 publication, 25%
Biology Direct
Biology Direct, 1, 25%
Biology Direct
1 publication, 25%
1

Citations by publishers

1
2
Springer Nature
Springer Nature, 2, 50%
Springer Nature
2 publications, 50%
Cardiology Research Institute
Cardiology Research Institute, 1, 25%
Cardiology Research Institute
1 publication, 25%
Pleiades Publishing
Pleiades Publishing, 1, 25%
Pleiades Publishing
1 publication, 25%
1
2
  • We do not take into account publications that without a DOI.
  • Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
  • Statistics recalculated weekly.
Metrics
Share
Cite this
GOST |
Cite this
GOST Copy
Borshchev Y. Y. et al. Probiotic Therapy with Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis Results in Infarct Size Limitation in Rats with Obesity and Chemically Induced Colitis // Microorganisms. 2022. Vol. 10. No. 11. p. 2293.
GOST all authors (up to 50) Copy
Borshchev Y. Y., Burovenko I. Y., Karaseva A. B., Minasian S. M., Protsak E. S., Borshchev V. Y., Semenova N. Y., Borshcheva O. V., Suvorov A. N., Galagudza M. M. Probiotic Therapy with Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis Results in Infarct Size Limitation in Rats with Obesity and Chemically Induced Colitis // Microorganisms. 2022. Vol. 10. No. 11. p. 2293.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.3390/microorganisms10112293
UR - https://doi.org/10.3390%2Fmicroorganisms10112293
TI - Probiotic Therapy with Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis Results in Infarct Size Limitation in Rats with Obesity and Chemically Induced Colitis
T2 - Microorganisms
AU - Borshchev, Yury Y
AU - Burovenko, Inessa Y
AU - Karaseva, Alena B
AU - Minasian, Sarkis M
AU - Protsak, Egor S
AU - Borshchev, Victor Y
AU - Semenova, Natalia Y
AU - Borshcheva, Olga V
AU - Suvorov, Alexander N
AU - Galagudza, Michael M.
PY - 2022
DA - 2022/11/18 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 2293
IS - 11
VL - 10
SN - 2076-2607
ER -
BibTex |
Cite this
BibTex Copy
@article{2022_Borshchev
author = {Yury Y Borshchev and Inessa Y Burovenko and Alena B Karaseva and Sarkis M Minasian and Egor S Protsak and Victor Y Borshchev and Natalia Y Semenova and Olga V Borshcheva and Alexander N Suvorov and Michael M. Galagudza},
title = {Probiotic Therapy with Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis Results in Infarct Size Limitation in Rats with Obesity and Chemically Induced Colitis},
journal = {Microorganisms},
year = {2022},
volume = {10},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {nov},
url = {https://doi.org/10.3390%2Fmicroorganisms10112293},
number = {11},
pages = {2293},
doi = {10.3390/microorganisms10112293}
}
MLA
Cite this
MLA Copy
Borshchev, Yury Y., et al. “Probiotic Therapy with Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis Results in Infarct Size Limitation in Rats with Obesity and Chemically Induced Colitis.” Microorganisms, vol. 10, no. 11, Nov. 2022, p. 2293. https://doi.org/10.3390%2Fmicroorganisms10112293.
Found error?