Open Access
Antiviral Efficacy of Ribavirin and Favipiravir against Hantaan Virus
2
Spiez Laboratory, Federal Office for Civil Protection, CH-3700 Spiez, Switzerland
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Publication type: Journal Article
Publication date: 2021-06-15
PubMed ID:
34203936
Microbiology (medical)
Microbiology
Virology
Abstract
Ecological changes, population movements and increasing urbanization promote the expansion of hantaviruses, placing humans at high risk of virus transmission and consequent diseases. The currently limited therapeutic options make the development of antiviral strategies an urgent need. Ribavirin is the only antiviral used currently to treat hemorrhagic fever with renal syndrome (HFRS) caused by Hantaan virus (HTNV), even though severe side effects are associated with this drug. We therefore investigated the antiviral activity of favipiravir, a new antiviral agent against RNA viruses. Both ribavirin and favipiravir demonstrated similar potent antiviral activity on HTNV infection. When combined, the efficacy of ribavirin is enhanced through the addition of low dose favipiravir, highlighting the possibility to provide better treatment than is currently available.
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25
Total citations:
25
Citations from 2024:
10
(40%)
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BibTex |
MLA
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GOST
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Mayor J. et al. Antiviral Efficacy of Ribavirin and Favipiravir against Hantaan Virus // Microorganisms. 2021. Vol. 9. No. 6. p. 1306.
GOST all authors (up to 50)
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Mayor J., Engler O. B., Rothenberger S. Antiviral Efficacy of Ribavirin and Favipiravir against Hantaan Virus // Microorganisms. 2021. Vol. 9. No. 6. p. 1306.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/microorganisms9061306
UR - https://doi.org/10.3390/microorganisms9061306
TI - Antiviral Efficacy of Ribavirin and Favipiravir against Hantaan Virus
T2 - Microorganisms
AU - Mayor, Jennifer
AU - Engler, Olivier B
AU - Rothenberger, Sylvia
PY - 2021
DA - 2021/06/15
PB - MDPI
SP - 1306
IS - 6
VL - 9
PMID - 34203936
SN - 2076-2607
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2021_Mayor,
author = {Jennifer Mayor and Olivier B Engler and Sylvia Rothenberger},
title = {Antiviral Efficacy of Ribavirin and Favipiravir against Hantaan Virus},
journal = {Microorganisms},
year = {2021},
volume = {9},
publisher = {MDPI},
month = {jun},
url = {https://doi.org/10.3390/microorganisms9061306},
number = {6},
pages = {1306},
doi = {10.3390/microorganisms9061306}
}
Cite this
MLA
Copy
Mayor, Jennifer, et al. “Antiviral Efficacy of Ribavirin and Favipiravir against Hantaan Virus.” Microorganisms, vol. 9, no. 6, Jun. 2021, p. 1306. https://doi.org/10.3390/microorganisms9061306.