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volume 24 issue 13 pages 2377

New Insights into the Cystine-Sulfite Reaction

Publication typeJournal Article
Publication date2019-06-27
scimago Q1
wos Q2
SJR0.865
CiteScore8.6
Impact factor4.6
ISSN14203049
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract

The mechanism by which cysteine-S-sulfate is formed from the reaction of sulfite with cystine in the absence of a dedicated oxidizing agent is investigated using high-resolution NMR. Changes to reactant ratio, pH, UV light exposure and temperature were evaluated to determine the most effective conditions to achieve the maximum yield of cysteine-S-sulfate without recourse to conventional oxidizing reagents. Herein evidence is provided for both nucleophilic and radical mechanisms, by which cysteine-S-sulfate can be generated with yields of up to 96%.

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GOST |
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GOST Copy
Zecchini M., Lucas R., Le Gresley A. New Insights into the Cystine-Sulfite Reaction // Molecules. 2019. Vol. 24. No. 13. p. 2377.
GOST all authors (up to 50) Copy
Zecchini M., Lucas R., Le Gresley A. New Insights into the Cystine-Sulfite Reaction // Molecules. 2019. Vol. 24. No. 13. p. 2377.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.3390/molecules24132377
UR - https://doi.org/10.3390/molecules24132377
TI - New Insights into the Cystine-Sulfite Reaction
T2 - Molecules
AU - Zecchini, Matteo
AU - Lucas, Robert
AU - Le Gresley, Adam
PY - 2019
DA - 2019/06/27
PB - MDPI
SP - 2377
IS - 13
VL - 24
PMID - 31252546
SN - 1420-3049
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2019_Zecchini,
author = {Matteo Zecchini and Robert Lucas and Adam Le Gresley},
title = {New Insights into the Cystine-Sulfite Reaction},
journal = {Molecules},
year = {2019},
volume = {24},
publisher = {MDPI},
month = {jun},
url = {https://doi.org/10.3390/molecules24132377},
number = {13},
pages = {2377},
doi = {10.3390/molecules24132377}
}
MLA
Cite this
MLA Copy
Zecchini, Matteo, et al. “New Insights into the Cystine-Sulfite Reaction.” Molecules, vol. 24, no. 13, Jun. 2019, p. 2377. https://doi.org/10.3390/molecules24132377.