Open Access
Porphyrin as Diagnostic and Therapeutic Agent
Publication type: Journal Article
Publication date: 2019-07-23
PubMed ID:
31340553
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
The synthesis and application of porphyrins has seen a huge shift towards research in porphyrin bio-molecular based systems in the past decade. The preferential localization of porphyrins in tumors, as well as their ability to generate reactive singlet oxygen and low dark toxicities has resulted in their use in therapeutic applications such as photodynamic therapy. However, their inherent lack of bio-distribution due to water insolubility has shifted research into porphyrin-nanomaterial conjugated systems to address this challenge. This has broadened their bio-applications, viz. bio-sensors, fluorescence tracking, in vivo magnetic resonance imaging (MRI), and positron emission tomography (PET)/CT imaging to photo-immuno-therapy just to highlight a few. This paper reviews the unique theranostic role of porphyrins in disease diagnosis and therapy. The review highlights porphyrin conjugated systems and their applications. The review ends by bringing current challenges and future perspectives of porphyrin based conjugated systems and their respective applications into light.
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Metrics
160
Total citations:
160
Citations from 2025:
35
(21.88%)
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MLA
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GOST
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Tsolekile N. et al. Porphyrin as Diagnostic and Therapeutic Agent // Molecules. 2019. Vol. 24. No. 14. p. 2669.
GOST all authors (up to 50)
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Tsolekile N., Oluwafemi O. S., Oluwafemi O. S. Porphyrin as Diagnostic and Therapeutic Agent // Molecules. 2019. Vol. 24. No. 14. p. 2669.
Cite this
RIS
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TY - JOUR
DO - 10.3390/molecules24142669
UR - https://doi.org/10.3390/molecules24142669
TI - Porphyrin as Diagnostic and Therapeutic Agent
T2 - Molecules
AU - Tsolekile, Ncediwe
AU - Oluwafemi, Oluwatobi S.
AU - Oluwafemi, Oluwatobi Samuel
PY - 2019
DA - 2019/07/23
PB - MDPI
SP - 2669
IS - 14
VL - 24
PMID - 31340553
SN - 1420-3049
ER -
Cite this
BibTex (up to 50 authors)
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@article{2019_Tsolekile,
author = {Ncediwe Tsolekile and Oluwatobi S. Oluwafemi and Oluwatobi Samuel Oluwafemi},
title = {Porphyrin as Diagnostic and Therapeutic Agent},
journal = {Molecules},
year = {2019},
volume = {24},
publisher = {MDPI},
month = {jul},
url = {https://doi.org/10.3390/molecules24142669},
number = {14},
pages = {2669},
doi = {10.3390/molecules24142669}
}
Cite this
MLA
Copy
Tsolekile, Ncediwe, et al. “Porphyrin as Diagnostic and Therapeutic Agent.” Molecules, vol. 24, no. 14, Jul. 2019, p. 2669. https://doi.org/10.3390/molecules24142669.