Open Access
Molecules, volume 24, issue 23, pages 4229
Aptamers: A Review of Their Chemical Properties and Modifications for Therapeutic Application
1
RIBOMIC Inc., Minato-ku, Tokyo 108-0071, Japan
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Publication type: Journal Article
Publication date: 2019-11-21
PubMed ID:
31766318
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
Aptamers are short, single-stranded oligonucleotides that bind to specific target molecules. The shape-forming feature of single-stranded oligonucleotides provides high affinity and excellent specificity toward targets. Hence, aptamers can be used as analogs of antibodies. In December 2004, the US Food and Drug Administration approved the first aptamer-based therapeutic, pegaptanib (Macugen), targeting vascular endothelial growth factor, for the treatment of age-related macular degeneration. Since then, however, no aptamer medication for public health has appeared. During these relatively silent years, many trials and improvements of aptamer therapeutics have been performed, opening multiple novel directions for the therapeutic application of aptamers. This review summarizes the basic characteristics of aptamers and the chemical modifications available for aptamer therapeutics.
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Adachi, NAKAMURA Aptamers: A Review of Their Chemical Properties and Modifications for Therapeutic Application // Molecules. 2019. Vol. 24. No. 23. p. 4229.
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Adachi, NAKAMURA Aptamers: A Review of Their Chemical Properties and Modifications for Therapeutic Application // Molecules. 2019. Vol. 24. No. 23. p. 4229.
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TY - JOUR
DO - 10.3390/molecules24234229
UR - https://doi.org/10.3390/molecules24234229
TI - Aptamers: A Review of Their Chemical Properties and Modifications for Therapeutic Application
T2 - Molecules
AU - Adachi
AU - NAKAMURA
PY - 2019
DA - 2019/11/21 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 4229
IS - 23
VL - 24
PMID - 31766318
SN - 1420-3049
SN - 1420-3049
ER -
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@article{2019_Adachi,
author = {Adachi and NAKAMURA},
title = {Aptamers: A Review of Their Chemical Properties and Modifications for Therapeutic Application},
journal = {Molecules},
year = {2019},
volume = {24},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {nov},
url = {https://doi.org/10.3390/molecules24234229},
number = {23},
pages = {4229},
doi = {10.3390/molecules24234229}
}
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Adachi, et al. “Aptamers: A Review of Their Chemical Properties and Modifications for Therapeutic Application.” Molecules, vol. 24, no. 23, Nov. 2019, p. 4229. https://doi.org/10.3390/molecules24234229.