Open Access

Molecules

, том 24 , издание 23 , страницы 4229

Aptamers: A Review of Their Chemical Properties and Modifications for Therapeutic Application

Adachi ¹

NAKAMURA ^{1, 2}

Скрыть аффилиации авторов Показать аффилиации авторов: 2 аффилиации

RIBOMIC Inc., Minato-ku, Tokyo 108-0071, Japan |

The institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan |

Тип публикации: Journal Article

Дата публикации: 2019-11-21

MDPI

Molecules

scimago Q1

wos Q2

БС1

SJR: 0.865

CiteScore: 8.6

Impact factor: 4.6

ISSN: 14203049

DOI: 10.3390/molecules24234229

Скопировать DOI

PubMed ID: 31766318

Organic Chemistry

Drug Discovery

Physical and Theoretical Chemistry

Pharmaceutical Science

Molecular Medicine

Analytical Chemistry

Chemistry (miscellaneous)

Краткое описание

Aptamers are short, single-stranded oligonucleotides that bind to specific target molecules. The shape-forming feature of single-stranded oligonucleotides provides high affinity and excellent specificity toward targets. Hence, aptamers can be used as analogs of antibodies. In December 2004, the US Food and Drug Administration approved the first aptamer-based therapeutic, pegaptanib (Macugen), targeting vascular endothelial growth factor, for the treatment of age-related macular degeneration. Since then, however, no aptamer medication for public health has appeared. During these relatively silent years, many trials and improvements of aptamer therapeutics have been performed, opening multiple novel directions for the therapeutic application of aptamers. This review summarizes the basic characteristics of aptamers and the chemical modifications available for aptamer therapeutics.

Найдено

2 цитирования

Давыдова Анна

🤝

к.х.н.

22 публикации, 283 цитирования

Индекс Хирша: 8

Институт химической биологии и фундаментальной медицины СО РАН

НИИ клинической и экспериментальной лимфологии — филиал ИЦиГ СО РАН

Области научных интересов

Биосенсоры

Каталитические нуклеиновые кислоты

Молекулярная биология

1 цитирование

Пономаренко Сергей

🥼 🤝

д.х.н., ч.-к., Российская академия наук

261 публикация, 6 104 цитирования, 64 рецензии

Индекс Хирша: 41

Московский государственный университет имени М.В. Ломоносова

Институт синтетических полимерных материалов им. Н.С. Ениколопова РАН

Области научных интересов

Self-assembly

Дендримеры

Жидкие кристаллы

Органическая электроника

1 цитирование

Уласов Илья

🤝

д.м.н.

120 публикаций, 6 758 цитирований, 97 рецензий

Индекс Хирша: 35

Первый Московский государственный медицинский университет имени И. М. Сеченова

Области научных интересов

3D cell culture

Вирусология

Молекулярная онкология

Онкология

Резистентность опухолей

Экспериментальная онкология

1 цитирование

Мещанинова Мария

к.х.н.

83 публикации, 883 цитирования

Индекс Хирша: 16

Институт химической биологии и фундаментальной медицины СО РАН

Области научных интересов

Аптамеры

Аптасенсоры

Биоорганическая химия

Взаимодействие с биополимерами

ДНК

Каталитические нуклеиновые кислоты

Химия нуклеиновых кислот

малые интерферирующие РНК

1 цитирование

Воробьева Мария

🥼 🤝

к.х.н.

50 публикаций, 625 цитирований

Индекс Хирша: 12

Институт химической биологии и фундаментальной медицины СО РАН

Области научных интересов

SELEX

Аптамеры

Аптасенсоры

Иммуновоспалительные ревматические заболевания

Олигонуклеотиды

Терапевтические аптамеры

Цитокины

Топ-30

Журналы

	1 2 3 4 5 6 7 8
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 8, 3.21% International Journal of Molecular Sciences 8 публикаций, 3.21%
Biosensors	Biosensors, 7, 2.81% Biosensors 7 публикаций, 2.81%
Chemical Reviews	Chemical Reviews, 6, 2.41% Chemical Reviews 6 публикаций, 2.41%
Molecules	Molecules, 5, 2.01% Molecules 5 публикаций, 2.01%
Progress in Molecular Biology and Translational Science	Progress in Molecular Biology and Translational Science, 5, 2.01% Progress in Molecular Biology and Translational Science 5 публикаций, 2.01%
Sensors	Sensors, 4, 1.61% Sensors 4 публикации, 1.61%
Advanced Drug Delivery Reviews	Advanced Drug Delivery Reviews, 4, 1.61% Advanced Drug Delivery Reviews 4 публикации, 1.61%
ACS Omega	ACS Omega, 4, 1.61% ACS Omega 4 публикации, 1.61%
Biomedicines	Biomedicines, 3, 1.2% Biomedicines 3 публикации, 1.2%
Frontiers in Cell and Developmental Biology	Frontiers in Cell and Developmental Biology, 3, 1.2% Frontiers in Cell and Developmental Biology 3 публикации, 1.2%
Biosensors and Bioelectronics: X	Biosensors and Bioelectronics: X, 3, 1.2% Biosensors and Bioelectronics: X 3 публикации, 1.2%
Journal of Drug Delivery Science and Technology	Journal of Drug Delivery Science and Technology, 3, 1.2% Journal of Drug Delivery Science and Technology 3 публикации, 1.2%
Analytical Chemistry	Analytical Chemistry, 3, 1.2% Analytical Chemistry 3 публикации, 1.2%
Chemosensors	Chemosensors, 3, 1.2% Chemosensors 3 публикации, 1.2%
Talanta	Talanta, 3, 1.2% Talanta 3 публикации, 1.2%
Microchimica Acta	Microchimica Acta, 3, 1.2% Microchimica Acta 3 публикации, 1.2%
Biosensors and Bioelectronics	Biosensors and Bioelectronics, 3, 1.2% Biosensors and Bioelectronics 3 публикации, 1.2%
The Analyst	The Analyst, 3, 1.2% The Analyst 3 публикации, 1.2%
Nucleic Acid Therapeutics	Nucleic Acid Therapeutics, 2, 0.8% Nucleic Acid Therapeutics 2 публикации, 0.8%
Micromachines	Micromachines, 2, 0.8% Micromachines 2 публикации, 0.8%
Cancers	Cancers, 2, 0.8% Cancers 2 публикации, 0.8%
Analytical and Bioanalytical Chemistry	Analytical and Bioanalytical Chemistry, 2, 0.8% Analytical and Bioanalytical Chemistry 2 публикации, 0.8%
Drug Discovery Today	Drug Discovery Today, 2, 0.8% Drug Discovery Today 2 публикации, 0.8%
Microchemical Journal	Microchemical Journal, 2, 0.8% Microchemical Journal 2 публикации, 0.8%
Colloids and Surfaces B: Biointerfaces	Colloids and Surfaces B: Biointerfaces, 2, 0.8% Colloids and Surfaces B: Biointerfaces 2 публикации, 0.8%
Life Sciences	Life Sciences, 2, 0.8% Life Sciences 2 публикации, 0.8%
Sensors and Actuators, B: Chemical	Sensors and Actuators, B: Chemical, 2, 0.8% Sensors and Actuators, B: Chemical 2 публикации, 0.8%
Methods	Methods, 2, 0.8% Methods 2 публикации, 0.8%
Biotechnology Progress	Biotechnology Progress, 2, 0.8% Biotechnology Progress 2 публикации, 0.8%
	1 2 3 4 5 6 7 8

Издатели

	10 20 30 40 50 60 70
Elsevier	Elsevier, 65, 26.1% Elsevier 65 публикаций, 26.1%
MDPI	MDPI, 46, 18.47% MDPI 46 публикаций, 18.47%
Springer Nature	Springer Nature, 28, 11.24% Springer Nature 28 публикаций, 11.24%
American Chemical Society (ACS)	American Chemical Society (ACS), 23, 9.24% American Chemical Society (ACS) 23 публикации, 9.24%
Wiley	Wiley, 21, 8.43% Wiley 21 публикация, 8.43%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 10, 4.02% Royal Society of Chemistry (RSC) 10 публикаций, 4.02%
Frontiers Media S.A.	Frontiers Media S.A., 9, 3.61% Frontiers Media S.A. 9 публикаций, 3.61%
Taylor & Francis	Taylor & Francis, 8, 3.21% Taylor & Francis 8 публикаций, 3.21%
Pleiades Publishing	Pleiades Publishing, 5, 2.01% Pleiades Publishing 5 публикаций, 2.01%
Mary Ann Liebert	Mary Ann Liebert, 3, 1.2% Mary Ann Liebert 3 публикации, 1.2%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 3, 1.2% Cold Spring Harbor Laboratory 3 публикации, 1.2%
SPIE-Intl Soc Optical Eng	SPIE-Intl Soc Optical Eng, 1, 0.4% SPIE-Intl Soc Optical Eng 1 публикация, 0.4%
IOP Publishing	IOP Publishing, 1, 0.4% IOP Publishing 1 публикация, 0.4%
Xi'an Jiaotong University	Xi'an Jiaotong University, 1, 0.4% Xi'an Jiaotong University 1 публикация, 0.4%
SAGE	SAGE, 1, 0.4% SAGE 1 публикация, 0.4%
Open Exploration Publishing	Open Exploration Publishing, 1, 0.4% Open Exploration Publishing 1 публикация, 0.4%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 1, 0.4% American Society for Biochemistry and Molecular Biology 1 публикация, 0.4%
SciELO	SciELO, 1, 0.4% SciELO 1 публикация, 0.4%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 1, 0.4% Public Library of Science (PLoS) 1 публикация, 0.4%
American Society of Hematology	American Society of Hematology, 1, 0.4% American Society of Hematology 1 публикация, 0.4%
Baishideng Publishing Group	Baishideng Publishing Group, 1, 0.4% Baishideng Publishing Group 1 публикация, 0.4%
Scientific Scholar	Scientific Scholar, 1, 0.4% Scientific Scholar 1 публикация, 0.4%
The Electrochemical Society	The Electrochemical Society, 1, 0.4% The Electrochemical Society 1 публикация, 0.4%
Walter de Gruyter	Walter de Gruyter, 1, 0.4% Walter de Gruyter 1 публикация, 0.4%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 0.4% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 публикация, 0.4%
OAE Publishing Inc.	OAE Publishing Inc., 1, 0.4% OAE Publishing Inc. 1 публикация, 0.4%
Acta Naturae Ltd	Acta Naturae Ltd, 1, 0.4% Acta Naturae Ltd 1 публикация, 0.4%
The Company of Biologists	The Company of Biologists, 1, 0.4% The Company of Biologists 1 публикация, 0.4%
Oxford University Press	Oxford University Press, 1, 0.4% Oxford University Press 1 публикация, 0.4%
	10 20 30 40 50 60 70

Мы не учитываем публикации, у которых нет DOI.
Статистика публикаций обновляется еженедельно.

Вы ученый?

Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.

Войти с ORCID

PDF

Метрики

251

Цитировать

ГОСТ |

Цитировать

ГОСТ Скопировать

Adachi, NAKAMURA Aptamers: A Review of Their Chemical Properties and Modifications for Therapeutic Application // Molecules. 2019. Vol. 24. No. 23. p. 4229.

ГОСТ со всеми авторами (до 50) Скопировать

Adachi, NAKAMURA Aptamers: A Review of Their Chemical Properties and Modifications for Therapeutic Application // Molecules. 2019. Vol. 24. No. 23. p. 4229.

RIS |

Цитировать

RIS Скопировать

TY - JOUR

DO - 10.3390/molecules24234229

UR - https://doi.org/10.3390/molecules24234229

TI - Aptamers: A Review of Their Chemical Properties and Modifications for Therapeutic Application

T2 - Molecules

AU - Adachi

AU - NAKAMURA

PY - 2019

DA - 2019/11/21

PB - MDPI

SP - 4229

IS - 23

VL - 24

PMID - 31766318

SN - 1420-3049

ER -

BibTex |

Цитировать

BibTex (до 50 авторов) Скопировать

@article{2019_Adachi,

author = {Adachi and NAKAMURA},

title = {Aptamers: A Review of Their Chemical Properties and Modifications for Therapeutic Application},

journal = {Molecules},

year = {2019},

volume = {24},

publisher = {MDPI},

month = {nov},

url = {https://doi.org/10.3390/molecules24234229},

number = {23},

pages = {4229},

doi = {10.3390/molecules24234229}

}

MLA

Цитировать

MLA Скопировать

Adachi, et al. “Aptamers: A Review of Their Chemical Properties and Modifications for Therapeutic Application.” Molecules, vol. 24, no. 23, Nov. 2019, p. 4229. https://doi.org/10.3390/molecules24234229.

Издатель

MDPI

Журнал

Molecules

scimago Q1

wos Q2

БС1

SJR

0.865

CiteScore

8.6

Impact factor

4.6

ISSN

14203049 (Print, Electronic)