Open Access
Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology
Anna Zielińska
1, 2
,
Filipa Carreiró
1
,
Ana M. Oliveira
1
,
Andreia Neves
1
,
Bárbara Pires
1
,
D Nagasamy Venkatesh
3
,
Alessandra Durazzo
4
,
Massimo Lucarini
4
,
Piotr Eder
5
,
Amélia M. Silva
6, 7
,
Eliana B. Souto
1, 9
3
7
Centre for Research and Technology of Agro-Environmental and Biological Sciences (CITAB-UTAD), Quinta de Prados, 5001-801 Vila Real, Portugal
|
8
Publication type: Journal Article
Publication date: 2020-08-15
PubMed ID:
32824172
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
Polymeric nanoparticles (NPs) are particles within the size range from 1 to 1000 nm and can be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric core. The term “nanoparticle” stands for both nanocapsules and nanospheres, which are distinguished by the morphological structure. Polymeric NPs have shown great potential for targeted delivery of drugs for the treatment of several diseases. In this review, we discuss the most commonly used methods for the production and characterization of polymeric NPs, the association efficiency of the active compound to the polymeric core, and the in vitro release mechanisms. As the safety of nanoparticles is a high priority, we also discuss the toxicology and ecotoxicology of nanoparticles to humans and to the environment.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
10
20
30
40
50
60
70
|
|
|
Pharmaceutics
64 publications, 5.15%
|
|
|
Journal of Drug Delivery Science and Technology
46 publications, 3.7%
|
|
|
Polymers
27 publications, 2.17%
|
|
|
International Journal of Molecular Sciences
26 publications, 2.09%
|
|
|
Pharmaceuticals
22 publications, 1.77%
|
|
|
BioNanoScience
18 publications, 1.45%
|
|
|
Molecules
17 publications, 1.37%
|
|
|
International Journal of Pharmaceutics
17 publications, 1.37%
|
|
|
International Journal of Nanomedicine
13 publications, 1.05%
|
|
|
AAPS PharmSciTech
12 publications, 0.97%
|
|
|
Nanomaterials
12 publications, 0.97%
|
|
|
Drug Delivery and Translational Research
11 publications, 0.88%
|
|
|
Journal of Controlled Release
11 publications, 0.88%
|
|
|
Nanomedicine
10 publications, 0.8%
|
|
|
Expert Opinion on Drug Delivery
10 publications, 0.8%
|
|
|
European Journal of Pharmaceutics and Biopharmaceutics
10 publications, 0.8%
|
|
|
Journal of Nanobiotechnology
9 publications, 0.72%
|
|
|
Colloids and Surfaces B: Biointerfaces
9 publications, 0.72%
|
|
|
Functionalized Smart Nanomaterials for Point-of-Care Testing
9 publications, 0.72%
|
|
|
Heliyon
8 publications, 0.64%
|
|
|
Advanced Drug Delivery Reviews
8 publications, 0.64%
|
|
|
International Journal of Biological Macromolecules
8 publications, 0.64%
|
|
|
European Polymer Journal
7 publications, 0.56%
|
|
|
Small
7 publications, 0.56%
|
|
|
Beilstein Journal of Nanotechnology
6 publications, 0.48%
|
|
|
Current Medicinal Chemistry
6 publications, 0.48%
|
|
|
Current Drug Delivery
6 publications, 0.48%
|
|
|
Applied Sciences (Switzerland)
6 publications, 0.48%
|
|
|
ACS Omega
6 publications, 0.48%
|
|
|
10
20
30
40
50
60
70
|
Publishers
|
50
100
150
200
250
300
350
400
|
|
|
Elsevier
357 publications, 28.72%
|
|
|
MDPI
238 publications, 19.15%
|
|
|
Springer Nature
216 publications, 17.38%
|
|
|
Wiley
75 publications, 6.03%
|
|
|
Taylor & Francis
71 publications, 5.71%
|
|
|
Bentham Science Publishers Ltd.
50 publications, 4.02%
|
|
|
American Chemical Society (ACS)
44 publications, 3.54%
|
|
|
Royal Society of Chemistry (RSC)
44 publications, 3.54%
|
|
|
Frontiers Media S.A.
28 publications, 2.25%
|
|
|
IOP Publishing
7 publications, 0.56%
|
|
|
IGI Global
7 publications, 0.56%
|
|
|
Beilstein-Institut
6 publications, 0.48%
|
|
|
A and V Publications
6 publications, 0.48%
|
|
|
IntechOpen
5 publications, 0.4%
|
|
|
Hindawi Limited
4 publications, 0.32%
|
|
|
Walter de Gruyter
4 publications, 0.32%
|
|
|
Ovid Technologies (Wolters Kluwer Health)
4 publications, 0.32%
|
|
|
Oxford University Press
3 publications, 0.24%
|
|
|
Medknow
3 publications, 0.24%
|
|
|
EDP Sciences
3 publications, 0.24%
|
|
|
Begell House
2 publications, 0.16%
|
|
|
AIP Publishing
2 publications, 0.16%
|
|
|
Thomas Telford
2 publications, 0.16%
|
|
|
Trans Tech Publications
2 publications, 0.16%
|
|
|
PeerJ
2 publications, 0.16%
|
|
|
The University of Jordan
2 publications, 0.16%
|
|
|
Pleiades Publishing
2 publications, 0.16%
|
|
|
SAGE
2 publications, 0.16%
|
|
|
Mary Ann Liebert
1 publication, 0.08%
|
|
|
50
100
150
200
250
300
350
400
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
1.2k
Total citations:
1243
Citations from 2024:
669
(53.82%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Zielińska A. et al. Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology // Molecules. 2020. Vol. 25. No. 16. p. 3731.
GOST all authors (up to 50)
Copy
Zielińska A., Carreiró F., Oliveira A. M., Neves A., Pires B., Venkatesh D. N., Durazzo A., Lucarini M., Eder P., Silva A. M., Santini A., Souto E. B. Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology // Molecules. 2020. Vol. 25. No. 16. p. 3731.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/molecules25163731
UR - https://doi.org/10.3390/molecules25163731
TI - Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology
T2 - Molecules
AU - Zielińska, Anna
AU - Carreiró, Filipa
AU - Oliveira, Ana M.
AU - Neves, Andreia
AU - Pires, Bárbara
AU - Venkatesh, D Nagasamy
AU - Durazzo, Alessandra
AU - Lucarini, Massimo
AU - Eder, Piotr
AU - Silva, Amélia M.
AU - Santini, Antonello
AU - Souto, Eliana B.
PY - 2020
DA - 2020/08/15
PB - MDPI
SP - 3731
IS - 16
VL - 25
PMID - 32824172
SN - 1420-3049
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2020_Zielińska,
author = {Anna Zielińska and Filipa Carreiró and Ana M. Oliveira and Andreia Neves and Bárbara Pires and D Nagasamy Venkatesh and Alessandra Durazzo and Massimo Lucarini and Piotr Eder and Amélia M. Silva and Antonello Santini and Eliana B. Souto},
title = {Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology},
journal = {Molecules},
year = {2020},
volume = {25},
publisher = {MDPI},
month = {aug},
url = {https://doi.org/10.3390/molecules25163731},
number = {16},
pages = {3731},
doi = {10.3390/molecules25163731}
}
Cite this
MLA
Copy
Zielińska, Anna, et al. “Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology.” Molecules, vol. 25, no. 16, Aug. 2020, p. 3731. https://doi.org/10.3390/molecules25163731.