Open Access
Antimicrobial Activity of Calixarenes and Related Macrocycles
Publication type: Journal Article
Publication date: 2020-11-05
PubMed ID:
33167339
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
Calixarenes and related macrocycles have been shown to have antimicrobial effects since the 1950s. This review highlights the antimicrobial properties of almost 200 calixarenes, resorcinarenes, and pillararenes acting as prodrugs, drug delivery agents, and inhibitors of biofilm formation. A particularly important development in recent years has been the use of macrocycles with substituents terminating in sugars as biofilm inhibitors through their interactions with lectins. Although many examples exist where calixarenes encapsulate, or incorporate, antimicrobial drugs, one of the main factors to emerge is the ability of functionalized macrocycles to engage in multivalent interactions with proteins, and thus inhibit cellular aggregation.
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Metrics
59
Total citations:
59
Citations from 2024:
22
(37%)
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RIS |
BibTex |
MLA
Cite this
GOST
Copy
Shurpik D. N. et al. Antimicrobial Activity of Calixarenes and Related Macrocycles // Molecules. 2020. Vol. 25. No. 21. p. 5145.
GOST all authors (up to 50)
Copy
Shurpik D. N., Padnya P., Stoikov I., Cragg P. J. Antimicrobial Activity of Calixarenes and Related Macrocycles // Molecules. 2020. Vol. 25. No. 21. p. 5145.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/molecules25215145
UR - https://doi.org/10.3390/molecules25215145
TI - Antimicrobial Activity of Calixarenes and Related Macrocycles
T2 - Molecules
AU - Shurpik, Dmitriy N
AU - Padnya, Pavel
AU - Stoikov, Ivan
AU - Cragg, Peter J
PY - 2020
DA - 2020/11/05
PB - MDPI
SP - 5145
IS - 21
VL - 25
PMID - 33167339
SN - 1420-3049
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2020_Shurpik,
author = {Dmitriy N Shurpik and Pavel Padnya and Ivan Stoikov and Peter J Cragg},
title = {Antimicrobial Activity of Calixarenes and Related Macrocycles},
journal = {Molecules},
year = {2020},
volume = {25},
publisher = {MDPI},
month = {nov},
url = {https://doi.org/10.3390/molecules25215145},
number = {21},
pages = {5145},
doi = {10.3390/molecules25215145}
}
Cite this
MLA
Copy
Shurpik, Dmitriy N., et al. “Antimicrobial Activity of Calixarenes and Related Macrocycles.” Molecules, vol. 25, no. 21, Nov. 2020, p. 5145. https://doi.org/10.3390/molecules25215145.