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Molecules, volume 26, issue 1, pages 26

Crystalline Peroxosolvates: Nature of the Coformer, Hydrogen-Bonded Networks and Clusters, Intermolecular Interactions

Medvedev Alexander G. ¹

Churakov Andrei V. ¹

Prikhodchenko Petr V. ¹

Lev Ovadia ²

Vener Mikhail V. ^{1, 3}

Hide authors affiliations Show authors affiliations: 3 affiliations

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskii Prosp. 31, 119991 Moscow, Russia |

The Casali Center of Applied Chemistry, The Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel |

Department of Quantum Chemistry, Mendeleev University of Chemical Technology, Miusskaya Square 9, 125047 Moscow, Russia |

Publication type: Journal Article

Publication date: 2020-12-23

Multidisciplinary Digital Publishing Institute (MDPI)

Journal: Molecules

Quartile SCImago

Quartile WOS

Impact factor: 4.6

ISSN: 14203049

DOI: 10.3390/molecules26010026

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PubMed ID: 33374602

Organic Chemistry

Drug Discovery

Physical and Theoretical Chemistry

Pharmaceutical Science

Molecular Medicine

Analytical Chemistry

Chemistry (miscellaneous)

Abstract

Despite the technological importance of urea perhydrate (percarbamide) and sodium percarbonate, and the growing technological attention to solid forms of peroxide, fewer than 45 peroxosolvates were known by 2000. However, recent advances in X-ray diffractometers more than tripled the number of structurally characterized peroxosolvates over the last 20 years, and even more so, allowed energetic interpretation and gleaning deeper insight into peroxosolvate stability. To date, 134 crystalline peroxosolvates have been structurally resolved providing sufficient insight to justify a first review article on the subject. In the first chapter of the review, a comprehensive analysis of the structural databases is carried out revealing the nature of the co-former in crystalline peroxosolvates. In the majority of cases, the coformers can be classified into three groups: (1) salts of inorganic and carboxylic acids; (2) amino acids, peptides, and related zwitterions; and (3) molecular compounds with a lone electron pair on nitrogen and/or oxygen atoms. The second chapter of the review is devoted to H-bonding in peroxosolvates. The database search and energy statistics revealed the importance of intermolecular hydrogen bonds (H-bonds) which play a structure-directing role in the considered crystals. H2O2 always forms two H-bonds as a proton donor, the energy of which is higher than the energy of analogous H-bonds existing in isostructural crystalline hydrates. This phenomenon is due to the higher acidity of H2O2 compared to water and the conformational mobility of H2O2. The dihedral angle H-O-O-H varies from 20 to 180° in crystalline peroxosolvates. As a result, infinite H-bonded 1D chain clusters are formed, consisting of H2O2 molecules, H2O2 and water molecules, and H2O2 and halogen anions. H2O2 can form up to four H-bonds as a proton acceptor. The third chapter of the review is devoted to energetic computations and in particular density functional theory with periodic boundary conditions. The approaches are considered in detail, allowing one to obtain the H-bond energies in crystals. DFT computations provide deeper insight into the stability of peroxosolvates and explain why percarbamide and sodium percarbonate are stable to H2O2/H2O isomorphic transformations. The review ends with a description of the main modern trends in the synthesis of crystalline peroxosolvates, in particular, the production of peroxosolvates of high-energy compounds and mixed pharmaceutical forms with antiseptic and analgesic effects.

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Medvedev A. G. et al. Crystalline Peroxosolvates: Nature of the Coformer, Hydrogen-Bonded Networks and Clusters, Intermolecular Interactions // Molecules. 2020. Vol. 26. No. 1. p. 26.

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Medvedev A. G., Churakov A. V., Prikhodchenko P. V., Lev O., Vener M. V. Crystalline Peroxosolvates: Nature of the Coformer, Hydrogen-Bonded Networks and Clusters, Intermolecular Interactions // Molecules. 2020. Vol. 26. No. 1. p. 26.

RIS |

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RIS Copy

TY - JOUR

DO - 10.3390/molecules26010026

UR - https://doi.org/10.3390%2Fmolecules26010026

TI - Crystalline Peroxosolvates: Nature of the Coformer, Hydrogen-Bonded Networks and Clusters, Intermolecular Interactions

T2 - Molecules

AU - Prikhodchenko, Petr V.

AU - Lev, Ovadia

AU - Medvedev, Alexander G.

AU - Churakov, Andrei V.

AU - Vener, Mikhail V.

PY - 2020

DA - 2020/12/23 00:00:00

PB - Multidisciplinary Digital Publishing Institute (MDPI)

SP - 26

IS - 1

VL - 26

PMID - 33374602

SN - 1420-3049

ER -

BibTex |

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BibTex Copy

@article{2020_Medvedev,

author = {Petr V. Prikhodchenko and Ovadia Lev and Alexander G. Medvedev and Andrei V. Churakov and Mikhail V. Vener},

title = {Crystalline Peroxosolvates: Nature of the Coformer, Hydrogen-Bonded Networks and Clusters, Intermolecular Interactions},

journal = {Molecules},

year = {2020},

volume = {26},

publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},

month = {dec},

url = {https://doi.org/10.3390%2Fmolecules26010026},

number = {1},

pages = {26},

doi = {10.3390/molecules26010026}

}

MLA

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MLA Copy

Medvedev, Alexander G., et al. “Crystalline Peroxosolvates: Nature of the Coformer, Hydrogen-Bonded Networks and Clusters, Intermolecular Interactions.” Molecules, vol. 26, no. 1, Dec. 2020, p. 26. https://doi.org/10.3390%2Fmolecules26010026.

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Publisher

Multidisciplinary Digital Publishing Institute (MDPI)

Journal

Molecules

Quartile SCImago

Quartile WOS

Impact factor

4.6

ISSN

14203049 (Print)

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