Open Access
The highly regioselective synthesis of novel imidazolidin-2-ones via the intramolecular cyclization/electrophilic substitution of urea derivatives and the evaluation of their anticancer activity
Almir S. Gazizov
1
,
Elizaveta A Kuznetsova
1
,
Dinara S Abdullaeva
2
,
Alexander R Burilov
1
,
Michail A. Pudovik
1
,
Alexandra D Voloshina
1
,
Victor V Syakaev
1
,
Anna P Lyubina
1
,
Syumbelya K Amerhanova
1
,
Julia K. Voronina
3, 4
Publication type: Journal Article
Publication date: 2021-07-22
PubMed ID:
34361587
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
A series of novel 4-(het)arylimidazoldin-2-ones were obtained by the acid-catalyzed reaction of (2,2-diethoxyethyl)ureas with aromatic and heterocyclic C-nucleophiles. The proposed approach to substituted imidazolidinones benefits from excellent regioselectivity, readily available starting materials and a simple procedure. The regioselectivity of the reaction was rationalized by quantum chemistry calculations and control experiments. The anti-cancer activity of the obtained compounds was tested in vitro.
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13
Total citations:
13
Citations from 2024:
4
(30%)
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MLA
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GOST
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Gazizov A. S. et al. The highly regioselective synthesis of novel imidazolidin-2-ones via the intramolecular cyclization/electrophilic substitution of urea derivatives and the evaluation of their anticancer activity // Molecules. 2021. Vol. 26. No. 15. p. 4432.
GOST all authors (up to 50)
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Gazizov A. S., Smolobochkin A. V., Kuznetsova E. A., Abdullaeva D. S., Burilov A. R., Pudovik M. A., Voloshina A. D., Syakaev V. V., Lyubina A. P., Amerhanova S. K., Voronina J. K. The highly regioselective synthesis of novel imidazolidin-2-ones via the intramolecular cyclization/electrophilic substitution of urea derivatives and the evaluation of their anticancer activity // Molecules. 2021. Vol. 26. No. 15. p. 4432.
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RIS
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TY - JOUR
DO - 10.3390/molecules26154432
UR - https://doi.org/10.3390/molecules26154432
TI - The highly regioselective synthesis of novel imidazolidin-2-ones via the intramolecular cyclization/electrophilic substitution of urea derivatives and the evaluation of their anticancer activity
T2 - Molecules
AU - Gazizov, Almir S.
AU - Smolobochkin, Andrey V.
AU - Kuznetsova, Elizaveta A
AU - Abdullaeva, Dinara S
AU - Burilov, Alexander R
AU - Pudovik, Michail A.
AU - Voloshina, Alexandra D
AU - Syakaev, Victor V
AU - Lyubina, Anna P
AU - Amerhanova, Syumbelya K
AU - Voronina, Julia K.
PY - 2021
DA - 2021/07/22
PB - MDPI
SP - 4432
IS - 15
VL - 26
PMID - 34361587
SN - 1420-3049
ER -
Cite this
BibTex (up to 50 authors)
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@article{2021_Gazizov,
author = {Almir S. Gazizov and Andrey V. Smolobochkin and Elizaveta A Kuznetsova and Dinara S Abdullaeva and Alexander R Burilov and Michail A. Pudovik and Alexandra D Voloshina and Victor V Syakaev and Anna P Lyubina and Syumbelya K Amerhanova and Julia K. Voronina},
title = {The highly regioselective synthesis of novel imidazolidin-2-ones via the intramolecular cyclization/electrophilic substitution of urea derivatives and the evaluation of their anticancer activity},
journal = {Molecules},
year = {2021},
volume = {26},
publisher = {MDPI},
month = {jul},
url = {https://doi.org/10.3390/molecules26154432},
number = {15},
pages = {4432},
doi = {10.3390/molecules26154432}
}
Cite this
MLA
Copy
Gazizov, Almir S., et al. “The highly regioselective synthesis of novel imidazolidin-2-ones via the intramolecular cyclization/electrophilic substitution of urea derivatives and the evaluation of their anticancer activity.” Molecules, vol. 26, no. 15, Jul. 2021, p. 4432. https://doi.org/10.3390/molecules26154432.