Open Access
An Efficient Synthesis of 2-CF3-3-Benzylindoles
Publication type: Journal Article
Publication date: 2021-08-22
PubMed ID:
34443672
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
The reaction of α-CF3-β-(2-nitroaryl) enamines with benzaldehydes afforded effectively α,β-diaryl-CF3-enones having nitro group. Subsequent reduction of nitro group by NH4HCO2-Pd/C system initiated intramolecular cyclization to give 2-CF3-3-benzylindoles. Target products can be prepared in up to quantitative yields. Broad synthetic scope of the reaction was shown. Probable mechanism of indole formation is proposed.
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Total citations:
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Citations from 2024:
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(66.67%)
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GOST
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Muzalevskiy V. M., Sizova Z. A., Nenajdenko V. G. An Efficient Synthesis of 2-CF3-3-Benzylindoles // Molecules. 2021. Vol. 26. No. 16. p. 5084.
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Muzalevskiy V. M., Sizova Z. A., Nenajdenko V. G. An Efficient Synthesis of 2-CF3-3-Benzylindoles // Molecules. 2021. Vol. 26. No. 16. p. 5084.
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RIS
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TY - JOUR
DO - 10.3390/molecules26165084
UR - https://doi.org/10.3390/molecules26165084
TI - An Efficient Synthesis of 2-CF3-3-Benzylindoles
T2 - Molecules
AU - Muzalevskiy, Vasily M.
AU - Sizova, Zoia A
AU - Nenajdenko, Valentine G.
PY - 2021
DA - 2021/08/22
PB - MDPI
SP - 5084
IS - 16
VL - 26
PMID - 34443672
SN - 1420-3049
ER -
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BibTex (up to 50 authors)
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@article{2021_Muzalevskiy,
author = {Vasily M. Muzalevskiy and Zoia A Sizova and Valentine G. Nenajdenko},
title = {An Efficient Synthesis of 2-CF3-3-Benzylindoles},
journal = {Molecules},
year = {2021},
volume = {26},
publisher = {MDPI},
month = {aug},
url = {https://doi.org/10.3390/molecules26165084},
number = {16},
pages = {5084},
doi = {10.3390/molecules26165084}
}
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MLA
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Muzalevskiy, Vasily M., et al. “An Efficient Synthesis of 2-CF3-3-Benzylindoles.” Molecules, vol. 26, no. 16, Aug. 2021, p. 5084. https://doi.org/10.3390/molecules26165084.