Open Access
Direct Conversion of 3-(2-Nitroethyl)-1H-Indoles into 2-(1H-Indol-2-yl)Acetonitriles
Elena V Aleksandrova
1
,
Igor Yu Grishin
1
,
Elena A Sorokina
2
,
Allison Wenger
3
,
Michael Rubin
1, 3
1
Publication type: Journal Article
Publication date: 2021-10-11
PubMed ID:
34684712
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
The recently discovered [4+1]-spirocyclization of nitroalkenes to indoles provided a convenient new approach to 2-(1H-indol-2-yl)acetonitriles. However, this reaction was complicated by the formation of inert 3-(2-nitroethyl)-1H-indole byproducts. Herein, we offer a workaround this problem that allows for effective transformation of the unwanted byproducts into acetonitrile target molecules.
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Citations from 2024:
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GOST
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Aksenov A. et al. Direct Conversion of 3-(2-Nitroethyl)-1H-Indoles into 2-(1H-Indol-2-yl)Acetonitriles // Molecules. 2021. Vol. 26. No. 20. p. 6132.
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Aksenov A., Aksenov N. A., Aleksandrova E. V., Aksenov D. A., Grishin I. Yu., Sorokina E. A., Wenger A., Rubin M. Direct Conversion of 3-(2-Nitroethyl)-1H-Indoles into 2-(1H-Indol-2-yl)Acetonitriles // Molecules. 2021. Vol. 26. No. 20. p. 6132.
Cite this
RIS
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TY - JOUR
DO - 10.3390/molecules26206132
UR - https://doi.org/10.3390/molecules26206132
TI - Direct Conversion of 3-(2-Nitroethyl)-1H-Indoles into 2-(1H-Indol-2-yl)Acetonitriles
T2 - Molecules
AU - Aksenov, Alexander V.
AU - Aksenov, Nicolai A.
AU - Aleksandrova, Elena V
AU - Aksenov, Dmitrii A
AU - Grishin, Igor Yu
AU - Sorokina, Elena A
AU - Wenger, Allison
AU - Rubin, Michael
PY - 2021
DA - 2021/10/11
PB - MDPI
SP - 6132
IS - 20
VL - 26
PMID - 34684712
SN - 1420-3049
ER -
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BibTex (up to 50 authors)
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@article{2021_Aksenov,
author = {Alexander V. Aksenov and Nicolai A. Aksenov and Elena V Aleksandrova and Dmitrii A Aksenov and Igor Yu Grishin and Elena A Sorokina and Allison Wenger and Michael Rubin},
title = {Direct Conversion of 3-(2-Nitroethyl)-1H-Indoles into 2-(1H-Indol-2-yl)Acetonitriles},
journal = {Molecules},
year = {2021},
volume = {26},
publisher = {MDPI},
month = {oct},
url = {https://doi.org/10.3390/molecules26206132},
number = {20},
pages = {6132},
doi = {10.3390/molecules26206132}
}
Cite this
MLA
Copy
Aksenov, Alexander V., et al. “Direct Conversion of 3-(2-Nitroethyl)-1H-Indoles into 2-(1H-Indol-2-yl)Acetonitriles.” Molecules, vol. 26, no. 20, Oct. 2021, p. 6132. https://doi.org/10.3390/molecules26206132.