Open Access
A Facile Approach to Bis(isoxazoles), Promising Ligands of the AMPA Receptor
Kseniya N. Sedenkova
1
,
Dmitry S Karlov
1
,
Yuri K. Grishin
1
,
Victor B. Rybakov
1
,
Tamara S. Kuznetsova
1
,
Vladimir L Zamoyski
2
,
Vladimir V. Grigoriev
1, 2
,
V. A. Palyulin
1
,
Elena B. Averina
1
Publication type: Journal Article
Publication date: 2021-10-23
PubMed ID:
34770819
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
A convenient synthetic approach to novel functionalized bis(isoxazoles), the promising bivalent ligands of the AMPA receptor, was elaborated. It was based on the heterocyclization reactions of readily available electrophilic alkenes with the tetranitromethane-triethylamine complex. The structural diversity of the synthesized compounds was demonstrated. In the electrophysiological experiments using the patch clamp technique on Purkinje neurons, the compound 1,4-phenylenedi(methylene)bis(5-aminoisoxazole-3-carboxylate) was shown to be highly potent positive modulator of the AMPA receptor, potentiating kainate-induced currents up to 70% at 10−11 M.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
3
|
|
|
International Journal of Molecular Sciences
3 publications, 21.43%
|
|
|
Molecules
2 publications, 14.29%
|
|
|
Mendeleev Communications
2 publications, 14.29%
|
|
|
Biomolecules
1 publication, 7.14%
|
|
|
Russian Chemical Bulletin
1 publication, 7.14%
|
|
|
ACS Omega
1 publication, 7.14%
|
|
|
Chemical Society Reviews
1 publication, 7.14%
|
|
|
Chemistry of Heterocyclic Compounds
1 publication, 7.14%
|
|
|
Oriental Journal Of Chemistry
1 publication, 7.14%
|
|
|
Journal of Xenobiotics
1 publication, 7.14%
|
|
|
1
2
3
|
Publishers
|
1
2
3
4
5
6
7
|
|
|
MDPI
7 publications, 50%
|
|
|
Springer Nature
2 publications, 14.29%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
2 publications, 14.29%
|
|
|
American Chemical Society (ACS)
1 publication, 7.14%
|
|
|
Royal Society of Chemistry (RSC)
1 publication, 7.14%
|
|
|
Oriental Scientific Publishing Company
1 publication, 7.14%
|
|
|
1
2
3
4
5
6
7
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
14
Total citations:
14
Citations from 2025:
2
(14.29%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Vasilenko D. A. et al. A Facile Approach to Bis(isoxazoles), Promising Ligands of the AMPA Receptor // Molecules. 2021. Vol. 26. No. 21. p. 6411.
GOST all authors (up to 50)
Copy
Vasilenko D. A., Sadovnikov K. S., Sedenkova K. N., Karlov D. S., Radchenko E. V., Grishin Y. K., Rybakov V. B., Kuznetsova T. S., Zamoyski V. L., Grigoriev V. V., Palyulin V. A., Averina E. B. A Facile Approach to Bis(isoxazoles), Promising Ligands of the AMPA Receptor // Molecules. 2021. Vol. 26. No. 21. p. 6411.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/molecules26216411
UR - https://doi.org/10.3390/molecules26216411
TI - A Facile Approach to Bis(isoxazoles), Promising Ligands of the AMPA Receptor
T2 - Molecules
AU - Vasilenko, Dmitry A.
AU - Sadovnikov, Kirill S
AU - Sedenkova, Kseniya N.
AU - Karlov, Dmitry S
AU - Radchenko, Eugene V.
AU - Grishin, Yuri K.
AU - Rybakov, Victor B.
AU - Kuznetsova, Tamara S.
AU - Zamoyski, Vladimir L
AU - Grigoriev, Vladimir V.
AU - Palyulin, V. A.
AU - Averina, Elena B.
PY - 2021
DA - 2021/10/23
PB - MDPI
SP - 6411
IS - 21
VL - 26
PMID - 34770819
SN - 1420-3049
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2021_Vasilenko,
author = {Dmitry A. Vasilenko and Kirill S Sadovnikov and Kseniya N. Sedenkova and Dmitry S Karlov and Eugene V. Radchenko and Yuri K. Grishin and Victor B. Rybakov and Tamara S. Kuznetsova and Vladimir L Zamoyski and Vladimir V. Grigoriev and V. A. Palyulin and Elena B. Averina},
title = {A Facile Approach to Bis(isoxazoles), Promising Ligands of the AMPA Receptor},
journal = {Molecules},
year = {2021},
volume = {26},
publisher = {MDPI},
month = {oct},
url = {https://doi.org/10.3390/molecules26216411},
number = {21},
pages = {6411},
doi = {10.3390/molecules26216411}
}
Cite this
MLA
Copy
Vasilenko, Dmitry A., et al. “A Facile Approach to Bis(isoxazoles), Promising Ligands of the AMPA Receptor.” Molecules, vol. 26, no. 21, Oct. 2021, p. 6411. https://doi.org/10.3390/molecules26216411.