Open Access
Discovery of New Ginsenol-Like Compounds with High Antiviral Activity
Тип публикации: Journal Article
Дата публикации: 2021-11-10
PubMed ID:
34833886
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Краткое описание
A number of framework amides with a ginsenol backbone have been synthesized using the Ritter reaction. We named the acetamide as Ginsamide. A method was developed for the synthesis of the corresponding amine and thioacetamide. The new compounds revealed a high activity against H1N1 influenza, which was confirmed using an animal model. Biological experiments were performed to determine the mechanism of action of the new agents, a ginsamide-resistant strain of influenza virus was obtained, and the pathogenicity of the resistant strain and the control strain was studied. It was shown that the emergence of resistance to Ginsamide was accompanied by a reduction in the pathogenicity of the influenza virus.
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ГОСТ
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Volobueva A. S. et al. Discovery of New Ginsenol-Like Compounds with High Antiviral Activity // Molecules. 2021. Vol. 26. No. 22. p. 6794.
ГОСТ со всеми авторами (до 50)
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Volobueva A. S., Yarovaya O. I., Kireeva M. V., Borisevich S. S., Kovaleva K., Mainagashev I. Ya., Gatilov Y. V., Ilyina M. G., Zarubaev V., Salakhutdinov N. F. Discovery of New Ginsenol-Like Compounds with High Antiviral Activity // Molecules. 2021. Vol. 26. No. 22. p. 6794.
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RIS
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TY - JOUR
DO - 10.3390/molecules26226794
UR - https://doi.org/10.3390/molecules26226794
TI - Discovery of New Ginsenol-Like Compounds with High Antiviral Activity
T2 - Molecules
AU - Volobueva, Aleksandrina S
AU - Yarovaya, Olga I.
AU - Kireeva, Marina V.
AU - Borisevich, Sophia S.
AU - Kovaleva, Kseniya
AU - Mainagashev, Iliya Ya
AU - Gatilov, Yuri V.
AU - Ilyina, Margarita G
AU - Zarubaev, V.V.
AU - Salakhutdinov, Nariman F.
PY - 2021
DA - 2021/11/10
PB - MDPI
SP - 6794
IS - 22
VL - 26
PMID - 34833886
SN - 1420-3049
ER -
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@article{2021_Volobueva,
author = {Aleksandrina S Volobueva and Olga I. Yarovaya and Marina V. Kireeva and Sophia S. Borisevich and Kseniya Kovaleva and Iliya Ya Mainagashev and Yuri V. Gatilov and Margarita G Ilyina and V.V. Zarubaev and Nariman F. Salakhutdinov},
title = {Discovery of New Ginsenol-Like Compounds with High Antiviral Activity},
journal = {Molecules},
year = {2021},
volume = {26},
publisher = {MDPI},
month = {nov},
url = {https://doi.org/10.3390/molecules26226794},
number = {22},
pages = {6794},
doi = {10.3390/molecules26226794}
}
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MLA
Скопировать
Volobueva, Aleksandrina S., et al. “Discovery of New Ginsenol-Like Compounds with High Antiviral Activity.” Molecules, vol. 26, no. 22, Nov. 2021, p. 6794. https://doi.org/10.3390/molecules26226794.