Open Access
Monoterpene-Containing Substituted Coumarins as Inhibitors of Respiratory Syncytial Virus (RSV) Replication
Tatyana M Khomenko
1
,
Anna A. Shtro
2
,
Yulia V Nikolaeva
2
,
Galina D Petukhova
2
,
Dina V. Korchagina
1
,
Nariman F. Salakhutdinov
1
Publication type: Journal Article
Publication date: 2021-12-10
PubMed ID:
34946573
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
Respiratory syncytial virus (RSV) is a critical cause of infant mortality. However, there are no vaccines and adequate drugs for its treatment. We showed, for the first time, that O-linked coumarin–monoterpene conjugates are effective RSV inhibitors. The most potent compounds are active against both RSV serotypes, A and B. According to the results of the time-of-addition experiment, the conjugates act at the early stages of virus cycle. Based on molecular modelling data, RSV F protein may be considered as a possible target.
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Metrics
11
Total citations:
11
Citations from 2024:
5
(45.45%)
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MLA
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GOST
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Khomenko T. M. et al. Monoterpene-Containing Substituted Coumarins as Inhibitors of Respiratory Syncytial Virus (RSV) Replication // Molecules. 2021. Vol. 26. No. 24. p. 7493.
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Khomenko T. M., Shtro A. A., Galochkina A. V., Nikolaeva Y. V., Petukhova G. D., Borisevich S. S., Korchagina D. V., Volcho K. P., Salakhutdinov N. F. Monoterpene-Containing Substituted Coumarins as Inhibitors of Respiratory Syncytial Virus (RSV) Replication // Molecules. 2021. Vol. 26. No. 24. p. 7493.
Cite this
RIS
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TY - JOUR
DO - 10.3390/molecules26247493
UR - https://doi.org/10.3390/molecules26247493
TI - Monoterpene-Containing Substituted Coumarins as Inhibitors of Respiratory Syncytial Virus (RSV) Replication
T2 - Molecules
AU - Khomenko, Tatyana M
AU - Shtro, Anna A.
AU - Galochkina, Anastasia V.
AU - Nikolaeva, Yulia V
AU - Petukhova, Galina D
AU - Borisevich, Sophia S.
AU - Korchagina, Dina V.
AU - Volcho, Konstantin P.
AU - Salakhutdinov, Nariman F.
PY - 2021
DA - 2021/12/10
PB - MDPI
SP - 7493
IS - 24
VL - 26
PMID - 34946573
SN - 1420-3049
ER -
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BibTex (up to 50 authors)
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@article{2021_Khomenko,
author = {Tatyana M Khomenko and Anna A. Shtro and Anastasia V. Galochkina and Yulia V Nikolaeva and Galina D Petukhova and Sophia S. Borisevich and Dina V. Korchagina and Konstantin P. Volcho and Nariman F. Salakhutdinov},
title = {Monoterpene-Containing Substituted Coumarins as Inhibitors of Respiratory Syncytial Virus (RSV) Replication},
journal = {Molecules},
year = {2021},
volume = {26},
publisher = {MDPI},
month = {dec},
url = {https://doi.org/10.3390/molecules26247493},
number = {24},
pages = {7493},
doi = {10.3390/molecules26247493}
}
Cite this
MLA
Copy
Khomenko, Tatyana M., et al. “Monoterpene-Containing Substituted Coumarins as Inhibitors of Respiratory Syncytial Virus (RSV) Replication.” Molecules, vol. 26, no. 24, Dec. 2021, p. 7493. https://doi.org/10.3390/molecules26247493.