Open Access

Molecules, volume 27, issue 4, pages 1396

BODIPY Conjugates as Functional Compounds for Medical Diagnostics and Treatment

Antina Elena ¹

Bumagina Natalia ¹

Marfin Yuriy ²

Guseva Galina B ¹

Nikitina Liliya E. ^{3, 4}

Sbytov Dmitry ²

Telegin Felix ²

Hide authors affiliations Show authors affiliations: 4 affiliations

G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya St., 153045 Ivanovo, Russia |

Inorganic Chemistry Department, Ivanovo State University of Chemistry and Technology, 7 Sheremetevskiy Ave., 153000 Ivanovo, Russia |

Department of General and Organic Chemistry, Kazan State Medical University, 49 Butlerova St., 420012 Kazan, Russia |

⁴

Biologically Active Terpenoids Laboratory, Kazan Federal University, 18 Kremlyovskaya St., 420008 Kazan, Russia |

Publication type: Journal Article

Publication date: 2022-02-18

Multidisciplinary Digital Publishing Institute (MDPI)

Journal: Molecules

Quartile SCImago

Quartile WOS

Impact factor: 4.6

ISSN: 14203049

DOI: 10.3390/molecules27041396

Copy DOI

PubMed ID: 35209191

Organic Chemistry

Drug Discovery

Physical and Theoretical Chemistry

Pharmaceutical Science

Molecular Medicine

Analytical Chemistry

Chemistry (miscellaneous)

Abstract

Fluorescent dyes absorbing and emitting in the visible and near-IR regions are promising for the development of fluorescent probes for labeling and bio-visualization of body cells. The ability to absorb and emit in the long-wavelength region increases the efficiency of recording the spectral signals of the probes due to the higher permeability of the skin layers. Compared to other fluorescent dyes, BODIPYs are attractive due to their excellent photophysical properties–narrow absorption and emission, intense fluorescence, simple signal modulation for the practical applications. As part of conjugates with biomolecules, BODIPY could act as a biomarker, but as therapeutic agent, which allows solving several problems at once-labeling or bioimaging and treatment based on the suppression of pathogenic microflora and cancer cells, which provides a huge potential for practical application of BODIPY conjugates in medicine. The review is devoted to the discussion of the recent, promising directions of BODIPY application in the field of conjugation with biomolecules. The first direction is associated with the development of BODIPY conjugates with drugs, including compounds of platinum, paclitaxel, chlorambucil, isoxazole, capsaicin, etc. The second direction is devoted to the labeling of vitamins, hormones, lipids, and other biomolecules to control the processes of their transport, localization in target cells, and metabolism. Within the framework of the third direction, the problem of obtaining functional optically active materials by conjugating BODIPY with other colored and fluorescent particles, in particular, phthalocyanines, is being solved.

By date By citations

Citations by journals

	1 2 3 4 5
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 5, 10.87% International Journal of Molecular Sciences 5 publications, 10.87%
Molecules	Molecules, 4, 8.7% Molecules 4 publications, 8.7%
Coordination Chemistry Reviews	Coordination Chemistry Reviews, 4, 8.7% Coordination Chemistry Reviews 4 publications, 8.7%
Chemistry - A European Journal	Chemistry - A European Journal, 3, 6.52% Chemistry - A European Journal 3 publications, 6.52%
Journal of Porphyrins and Phthalocyanines	Journal of Porphyrins and Phthalocyanines, 2, 4.35% Journal of Porphyrins and Phthalocyanines 2 publications, 4.35%
Dyes and Pigments	Dyes and Pigments, 1, 2.17% Dyes and Pigments 1 publication, 2.17%
Physical Chemistry Chemical Physics	Physical Chemistry Chemical Physics, 1, 2.17% Physical Chemistry Chemical Physics 1 publication, 2.17%
Journal of Medicinal Chemistry	Journal of Medicinal Chemistry, 1, 2.17% Journal of Medicinal Chemistry 1 publication, 2.17%
Antioxidants	Antioxidants, 1, 2.17% Antioxidants 1 publication, 2.17%
Polymers	Polymers, 1, 2.17% Polymers 1 publication, 2.17%
Computational and Theoretical Chemistry	Computational and Theoretical Chemistry, 1, 2.17% Computational and Theoretical Chemistry 1 publication, 2.17%
Tetrahedron	Tetrahedron, 1, 2.17% Tetrahedron 1 publication, 2.17%
TrAC - Trends in Analytical Chemistry	TrAC - Trends in Analytical Chemistry, 1, 2.17% TrAC - Trends in Analytical Chemistry 1 publication, 2.17%
European Journal of Medicinal Chemistry Reports	European Journal of Medicinal Chemistry Reports, 1, 2.17% European Journal of Medicinal Chemistry Reports 1 publication, 2.17%
ACS Omega	ACS Omega, 1, 2.17% ACS Omega 1 publication, 2.17%
Journal of Physical Chemistry A	Journal of Physical Chemistry A, 1, 2.17% Journal of Physical Chemistry A 1 publication, 2.17%
ACS Applied Nano Materials	ACS Applied Nano Materials, 1, 2.17% ACS Applied Nano Materials 1 publication, 2.17%
Chemistry - An Asian Journal	Chemistry - An Asian Journal, 1, 2.17% Chemistry - An Asian Journal 1 publication, 2.17%
ChemBioChem	ChemBioChem, 1, 2.17% ChemBioChem 1 publication, 2.17%
Inorganics	Inorganics, 1, 2.17% Inorganics 1 publication, 2.17%
Journal of Photochemistry and Photobiology A: Chemistry	Journal of Photochemistry and Photobiology A: Chemistry, 1, 2.17% Journal of Photochemistry and Photobiology A: Chemistry 1 publication, 2.17%
ChemPhotoChem	ChemPhotoChem, 1, 2.17% ChemPhotoChem 1 publication, 2.17%
Journal of Molecular Structure	Journal of Molecular Structure, 1, 2.17% Journal of Molecular Structure 1 publication, 2.17%
TARGETS	TARGETS, 1, 2.17% TARGETS 1 publication, 2.17%
ChemistrySelect	ChemistrySelect, 1, 2.17% ChemistrySelect 1 publication, 2.17%
Journal of Computational Science	Journal of Computational Science, 1, 2.17% Journal of Computational Science 1 publication, 2.17%
Biomolecules	Biomolecules, 1, 2.17% Biomolecules 1 publication, 2.17%
Colorants	Colorants, 1, 2.17% Colorants 1 publication, 2.17%
International Endodontic Journal	International Endodontic Journal, 1, 2.17% International Endodontic Journal 1 publication, 2.17%
Russian Chemical Reviews	Russian Chemical Reviews, 1, 2.17% Russian Chemical Reviews 1 publication, 2.17%
	1 2 3 4 5

Citations by publishers

	2 4 6 8 10 12 14
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 14, 30.43% Multidisciplinary Digital Publishing Institute (MDPI) 14 publications, 30.43%
Elsevier	Elsevier, 13, 28.26% Elsevier 13 publications, 28.26%
Wiley	Wiley, 8, 17.39% Wiley 8 publications, 17.39%
American Chemical Society (ACS)	American Chemical Society (ACS), 6, 13.04% American Chemical Society (ACS) 6 publications, 13.04%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 2, 4.35% Royal Society of Chemistry (RSC) 2 publications, 4.35%
World Scientific	World Scientific, 2, 4.35% World Scientific 2 publications, 4.35%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 2.17% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 publication, 2.17%
	2 4 6 8 10 12 14

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Antina E. et al. BODIPY Conjugates as Functional Compounds for Medical Diagnostics and Treatment // Molecules. 2022. Vol. 27. No. 4. p. 1396.

GOST all authors (up to 50) Copy

Antina E., Bumagina N., Marfin Y., Guseva G. B., Nikitina L. E., Sbytov D., Telegin F. BODIPY Conjugates as Functional Compounds for Medical Diagnostics and Treatment // Molecules. 2022. Vol. 27. No. 4. p. 1396.

RIS |

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TY - JOUR

DO - 10.3390/molecules27041396

UR - https://doi.org/10.3390%2Fmolecules27041396

TI - BODIPY Conjugates as Functional Compounds for Medical Diagnostics and Treatment

T2 - Molecules

AU - Antina, Elena

AU - Bumagina, Natalia

AU - Marfin, Yuriy

AU - Sbytov, Dmitry

AU - Guseva, Galina B

AU - Nikitina, Liliya E.

AU - Telegin, Felix

PY - 2022

DA - 2022/02/18 00:00:00

PB - Multidisciplinary Digital Publishing Institute (MDPI)

SP - 1396

IS - 4

VL - 27

PMID - 35209191

SN - 1420-3049

ER -

BibTex |

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BibTex Copy

@article{2022_Antina,

author = {Elena Antina and Natalia Bumagina and Yuriy Marfin and Dmitry Sbytov and Galina B Guseva and Liliya E. Nikitina and Felix Telegin},

title = {BODIPY Conjugates as Functional Compounds for Medical Diagnostics and Treatment},

journal = {Molecules},

year = {2022},

volume = {27},

publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},

month = {feb},

url = {https://doi.org/10.3390%2Fmolecules27041396},

number = {4},

pages = {1396},

doi = {10.3390/molecules27041396}

}

MLA

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Antina, Elena, et al. “BODIPY Conjugates as Functional Compounds for Medical Diagnostics and Treatment.” Molecules, vol. 27, no. 4, Feb. 2022, p. 1396. https://doi.org/10.3390%2Fmolecules27041396.

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Publisher

Multidisciplinary Digital Publishing Institute (MDPI)

Journal

Molecules

Quartile SCImago

Quartile WOS

Impact factor

4.6

ISSN

14203049 (Print)

Labs

Chemistry and molecular photonics of dipyrromethene dyes and phosphors

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