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Molecules
,  volume 27 ,  issue 9 ,  pages 2763

New Cysteine-Containing PEG-Glycerolipid Increases the Bloodstream Circulation Time of Upconverting Nanoparticles

Publication type: Journal Article
Publication date: 2022-04-26
MDPI
scimago Q1
wos Q2
SJR: 0.865
CiteScore: 8.6
Impact factor: 4.6
ISSN: 14203049
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract

Upconverting nanoparticles have unique spectral and photophysical properties that make them suitable for development of theranostics for imaging and treating large and deep-seated tumors. Nanoparticles based on NaYF4 crystals doped with lanthanides Yb3+ and Er3+ were obtained by the high-temperature decomposition of trifluoroacetates in oleic acid and 1-octadecene. Such particles have pronounced hydrophobic properties. Therefore, to obtain stable dispersions in aqueous media for the study of their properties in vivo and in vitro, the polyethylene glycol (PEG)-glycerolipids of various structures were obtained. To increase the circulation time of PEG-lipid coated nanoparticles in the bloodstream, long-chain substituents are needed to be attached to the glycerol backbone using ether bonds. To prevent nanoparticle aggregation, an L-cysteine-derived negatively charged carboxy group should be included in the lipid molecule.

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GOST Copy
Nikolaeva M. E. et al. New Cysteine-Containing PEG-Glycerolipid Increases the Bloodstream Circulation Time of Upconverting Nanoparticles // Molecules. 2022. Vol. 27. No. 9. p. 2763.
GOST all authors (up to 50) Copy
Nikolaeva M. E., Nechaev A. V., Shmendel E. V., Shmendel E., Akasov R. A., Maslov M., Mironov A. F. New Cysteine-Containing PEG-Glycerolipid Increases the Bloodstream Circulation Time of Upconverting Nanoparticles // Molecules. 2022. Vol. 27. No. 9. p. 2763.
RIS |
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RIS Copy
TY - JOUR
DO - 10.3390/molecules27092763
UR - https://www.mdpi.com/1420-3049/27/9/2763
TI - New Cysteine-Containing PEG-Glycerolipid Increases the Bloodstream Circulation Time of Upconverting Nanoparticles
T2 - Molecules
AU - Nikolaeva, Maria E
AU - Nechaev, Andrey V.
AU - Shmendel, Elena V
AU - Shmendel, Elena
AU - Akasov, Roman A.
AU - Maslov, Michael
AU - Mironov, Andrey F
PY - 2022
DA - 2022/04/26
PB - MDPI
SP - 2763
IS - 9
VL - 27
PMID - 35566114
SN - 1420-3049
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2022_Nikolaeva,
author = {Maria E Nikolaeva and Andrey V. Nechaev and Elena V Shmendel and Elena Shmendel and Roman A. Akasov and Michael Maslov and Andrey F Mironov},
title = {New Cysteine-Containing PEG-Glycerolipid Increases the Bloodstream Circulation Time of Upconverting Nanoparticles},
journal = {Molecules},
year = {2022},
volume = {27},
publisher = {MDPI},
month = {apr},
url = {https://www.mdpi.com/1420-3049/27/9/2763},
number = {9},
pages = {2763},
doi = {10.3390/molecules27092763}
}
MLA
Cite this
MLA Copy
Nikolaeva, Maria E., et al. “New Cysteine-Containing PEG-Glycerolipid Increases the Bloodstream Circulation Time of Upconverting Nanoparticles.” Molecules, vol. 27, no. 9, Apr. 2022, p. 2763. https://www.mdpi.com/1420-3049/27/9/2763.