Open Access
Molecules, volume 27, issue 9, pages 2763
New Cysteine-Containing PEG-Glycerolipid Increases the Bloodstream Circulation Time of Upconverting Nanoparticles
Nechaev Andrey V.
1
,
Shmendel Elena V
1
,
Akasov Roman A.
2
,
Maslov Michael
1
,
Mironov Andrey F
1
Publication type: Journal Article
Publication date: 2022-04-26
PubMed ID:
35566114
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
Upconverting nanoparticles have unique spectral and photophysical properties that make them suitable for development of theranostics for imaging and treating large and deep-seated tumors. Nanoparticles based on NaYF4 crystals doped with lanthanides Yb3+ and Er3+ were obtained by the high-temperature decomposition of trifluoroacetates in oleic acid and 1-octadecene. Such particles have pronounced hydrophobic properties. Therefore, to obtain stable dispersions in aqueous media for the study of their properties in vivo and in vitro, the polyethylene glycol (PEG)-glycerolipids of various structures were obtained. To increase the circulation time of PEG-lipid coated nanoparticles in the bloodstream, long-chain substituents are needed to be attached to the glycerol backbone using ether bonds. To prevent nanoparticle aggregation, an L-cysteine-derived negatively charged carboxy group should be included in the lipid molecule.
Citations by journals
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Micromachines
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Micromachines
1 publication, 100%
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Citations by publishers
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 100%
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Nikolaeva M. E. et al. New Cysteine-Containing PEG-Glycerolipid Increases the Bloodstream Circulation Time of Upconverting Nanoparticles // Molecules. 2022. Vol. 27. No. 9. p. 2763.
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Nikolaeva M. E., Nechaev A. V., Shmendel E. V., Akasov R. A., Maslov M., Mironov A. F. New Cysteine-Containing PEG-Glycerolipid Increases the Bloodstream Circulation Time of Upconverting Nanoparticles // Molecules. 2022. Vol. 27. No. 9. p. 2763.
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TY - JOUR
DO - 10.3390/molecules27092763
UR - https://doi.org/10.3390%2Fmolecules27092763
TI - New Cysteine-Containing PEG-Glycerolipid Increases the Bloodstream Circulation Time of Upconverting Nanoparticles
T2 - Molecules
AU - Nikolaeva, Maria E
AU - Mironov, Andrey F
AU - Nechaev, Andrey V.
AU - Shmendel, Elena V
AU - Akasov, Roman A.
AU - Maslov, Michael
PY - 2022
DA - 2022/04/26 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 2763
IS - 9
VL - 27
PMID - 35566114
SN - 1420-3049
ER -
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@article{2022_Nikolaeva,
author = {Maria E Nikolaeva and Andrey F Mironov and Andrey V. Nechaev and Elena V Shmendel and Roman A. Akasov and Michael Maslov},
title = {New Cysteine-Containing PEG-Glycerolipid Increases the Bloodstream Circulation Time of Upconverting Nanoparticles},
journal = {Molecules},
year = {2022},
volume = {27},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {apr},
url = {https://doi.org/10.3390%2Fmolecules27092763},
number = {9},
pages = {2763},
doi = {10.3390/molecules27092763}
}
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Nikolaeva, Maria E., et al. “New Cysteine-Containing PEG-Glycerolipid Increases the Bloodstream Circulation Time of Upconverting Nanoparticles.” Molecules, vol. 27, no. 9, Apr. 2022, p. 2763. https://doi.org/10.3390%2Fmolecules27092763.
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