Open Access

Molecules

, volume 27 , issue 17 , pages 5702

Ionic Liquids as Organocatalysts for Nucleophilic Fluorination: Concepts and Perspectives

Young-Ho Oh ¹

Dong Wook Kim ²

Sungyul Lee ¹

Hide authors affiliations Show authors affiliations: 2 affiliations

Department of Applied Chemistry, Kyung Hee University, Duckyoung-daero 1732, Yongin City 446-701, Korea |

Department of Chemistry, Inha University, 100 Inha-ro, Nam-gu, Incheon 402-751, Korea |

Publication type: Journal Article

Publication date: 2022-09-04

MDPI

Molecules

scimago Q1

wos Q2

SJR: 0.865

CiteScore: 8.6

Impact factor: 4.6

ISSN: 14203049

DOI: 10.3390/molecules27175702

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PubMed ID: 36080470

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Abstract

Besides their extremely useful properties as solvent, ionic liquids (ILs) are now considered to be highly instructive tools for enhancing the rates of chemical reactions. The ionic nature of the IL anion and cation seems to be the origin of this fascinating function of ILs as organocatalyst/promoter through their strong Coulombic forces on other ionic species in the reaction and also through the formation of hydrogen bonds with various functional groups in substrates. It is now possible to tailor-make ILs for specific purposes as solvent/promoters in a variety of situations by carefully monitoring these interactions. Despite the enormous potentiality, it seems that the application of ILs as organocatalysts/promoters for chemical reactions have not been fully achieved so far. Herein, we review recent developments of ILs for promoting the nucleophilic reactions, focusing on fluorination. Various aspects of the processes, such as organocatalytic capability, reaction mechanisms and salt effects, are discussed.

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Oh Y., Kim D. W., Lee S. Ionic Liquids as Organocatalysts for Nucleophilic Fluorination: Concepts and Perspectives // Molecules. 2022. Vol. 27. No. 17. p. 5702.

GOST all authors (up to 50) Copy

Oh Y., Kim D. W., Lee S. Ionic Liquids as Organocatalysts for Nucleophilic Fluorination: Concepts and Perspectives // Molecules. 2022. Vol. 27. No. 17. p. 5702.

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RIS Copy

TY - JOUR

DO - 10.3390/molecules27175702

UR - https://doi.org/10.3390/molecules27175702

TI - Ionic Liquids as Organocatalysts for Nucleophilic Fluorination: Concepts and Perspectives

T2 - Molecules

AU - Oh, Young-Ho

AU - Kim, Dong Wook

AU - Lee, Sungyul

PY - 2022

DA - 2022/09/04

PB - MDPI

SP - 5702

IS - 17

VL - 27

PMID - 36080470

SN - 1420-3049

ER -

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BibTex (up to 50 authors) Copy

@article{2022_Oh,

author = {Young-Ho Oh and Dong Wook Kim and Sungyul Lee},

title = {Ionic Liquids as Organocatalysts for Nucleophilic Fluorination: Concepts and Perspectives},

journal = {Molecules},

year = {2022},

volume = {27},

publisher = {MDPI},

month = {sep},

url = {https://doi.org/10.3390/molecules27175702},

number = {17},

pages = {5702},

doi = {10.3390/molecules27175702}

}

MLA

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MLA Copy

Oh, Young-Ho, et al. “Ionic Liquids as Organocatalysts for Nucleophilic Fluorination: Concepts and Perspectives.” Molecules, vol. 27, no. 17, Sep. 2022, p. 5702. https://doi.org/10.3390/molecules27175702.

Publisher

MDPI

Journal

Molecules

scimago Q1

wos Q2

SJR

0.865

CiteScore

8.6

Impact factor

4.6

ISSN

14203049 (Print, Electronic)