Open Access
New Inhibitors of Respiratory Syncytial Virus (RSV) Replication Based on Monoterpene-Substituted Arylcoumarins
Tatyana M Khomenko
1
,
Anna A. Shtro
2
,
Yulia V Nikolaeva
2
,
Anzhelika V Garshinina
2
,
Sophia S. Borisevich
3, 4
,
Dina V. Korchagina
1
,
Nariman F. Salakhutdinov
1
Publication type: Journal Article
Publication date: 2023-03-15
PubMed ID:
36985645
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
Respiratory syncytial virus (RSV) causes annual epidemics of respiratory infection. Usually harmless to adults, the RSV infection can be dangerous to children under 3 years of age and elderly people over 65 years of age, often causing serious problems, even death. At present, there are no vaccines and specific chemotherapeutic agents for the treatment of this disease, so the search for low-molecular weight compounds to combat RSV is a challenge. In this work, we have shown, for the first time, that monoterpene-substituted arylcoumarins are efficient RSV replication inhibitors at low micromolar concentrations. The most active compound has a selectivity index of about 200 and acts most effectively at the early stages of infection. The F protein of RSV is a potential target for these compounds, which is also confirmed by molecular docking and molecular dynamics simulation data.
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Metrics
8
Total citations:
8
Citations from 2024:
5
(62.5%)
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MLA
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GOST
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Khomenko T. M. et al. New Inhibitors of Respiratory Syncytial Virus (RSV) Replication Based on Monoterpene-Substituted Arylcoumarins // Molecules. 2023. Vol. 28. No. 6. p. 2673.
GOST all authors (up to 50)
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Khomenko T. M., Shtro A. A., Galochkina A. V., Nikolaeva Y. V., Garshinina A. V., Borisevich S. S., Korchagina D. V., Volcho K. P., Salakhutdinov N. F. New Inhibitors of Respiratory Syncytial Virus (RSV) Replication Based on Monoterpene-Substituted Arylcoumarins // Molecules. 2023. Vol. 28. No. 6. p. 2673.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/molecules28062673
UR - https://doi.org/10.3390/molecules28062673
TI - New Inhibitors of Respiratory Syncytial Virus (RSV) Replication Based on Monoterpene-Substituted Arylcoumarins
T2 - Molecules
AU - Khomenko, Tatyana M
AU - Shtro, Anna A.
AU - Galochkina, Anastasia V.
AU - Nikolaeva, Yulia V
AU - Garshinina, Anzhelika V
AU - Borisevich, Sophia S.
AU - Korchagina, Dina V.
AU - Volcho, Konstantin P.
AU - Salakhutdinov, Nariman F.
PY - 2023
DA - 2023/03/15
PB - MDPI
SP - 2673
IS - 6
VL - 28
PMID - 36985645
SN - 1420-3049
ER -
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BibTex (up to 50 authors)
Copy
@article{2023_Khomenko,
author = {Tatyana M Khomenko and Anna A. Shtro and Anastasia V. Galochkina and Yulia V Nikolaeva and Anzhelika V Garshinina and Sophia S. Borisevich and Dina V. Korchagina and Konstantin P. Volcho and Nariman F. Salakhutdinov},
title = {New Inhibitors of Respiratory Syncytial Virus (RSV) Replication Based on Monoterpene-Substituted Arylcoumarins},
journal = {Molecules},
year = {2023},
volume = {28},
publisher = {MDPI},
month = {mar},
url = {https://doi.org/10.3390/molecules28062673},
number = {6},
pages = {2673},
doi = {10.3390/molecules28062673}
}
Cite this
MLA
Copy
Khomenko, Tatyana M., et al. “New Inhibitors of Respiratory Syncytial Virus (RSV) Replication Based on Monoterpene-Substituted Arylcoumarins.” Molecules, vol. 28, no. 6, Mar. 2023, p. 2673. https://doi.org/10.3390/molecules28062673.