Open Access
Open access
MDPI
Molecules
,  volume 28 ,  issue 7 ,  pages 3193

The Synthesis and Biological Applications of the 1,2,3-Dithiazole Scaffold

Publication type: Journal Article
Publication date: 2023-04-03
MDPI
scimago Q1
wos Q2
SJR: 0.865
CiteScore: 8.6
Impact factor: 4.6
ISSN: 14203049
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract

The 1,2,3-dithiazole is an underappreciated scaffold in medicinal chemistry despite possessing a wide variety of nascent pharmacological activities. The scaffold has a potential wealth of opportunities within these activities and further afield. The 1,2,3-dithiazole scaffold has already been reported as an antifungal, herbicide, antibacterial, anticancer agent, antiviral, antifibrotic, and is a melanin and Arabidopsis gibberellin 2-oxidase inhibitor. These structure activity relationships are discussed in detail, along with insights and future directions. The review also highlights selected synthetic strategies developed towards the 1,2,3-dithiazole scaffold, how these are integrated to accessibility of chemical space, and to the prism of current and future biological activities.

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GOST |
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GOST Copy
Kalogirou A. et al. The Synthesis and Biological Applications of the 1,2,3-Dithiazole Scaffold // Molecules. 2023. Vol. 28. No. 7. p. 3193.
GOST all authors (up to 50) Copy
Kalogirou A., Oh H. J., Asquith C. R. M. The Synthesis and Biological Applications of the 1,2,3-Dithiazole Scaffold // Molecules. 2023. Vol. 28. No. 7. p. 3193.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.3390/molecules28073193
UR - https://doi.org/10.3390/molecules28073193
TI - The Synthesis and Biological Applications of the 1,2,3-Dithiazole Scaffold
T2 - Molecules
AU - Kalogirou, Andreas
AU - Oh, Hans J.
AU - Asquith, Christopher R M
PY - 2023
DA - 2023/04/03
PB - MDPI
SP - 3193
IS - 7
VL - 28
PMID - 37049953
SN - 1420-3049
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2023_Kalogirou,
author = {Andreas Kalogirou and Hans J. Oh and Christopher R M Asquith},
title = {The Synthesis and Biological Applications of the 1,2,3-Dithiazole Scaffold},
journal = {Molecules},
year = {2023},
volume = {28},
publisher = {MDPI},
month = {apr},
url = {https://doi.org/10.3390/molecules28073193},
number = {7},
pages = {3193},
doi = {10.3390/molecules28073193}
}
MLA
Cite this
MLA Copy
Kalogirou, Andreas, et al. “The Synthesis and Biological Applications of the 1,2,3-Dithiazole Scaffold.” Molecules, vol. 28, no. 7, Apr. 2023, p. 3193. https://doi.org/10.3390/molecules28073193.