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Bridged 1,2,4-Trioxolanes: SnCl4—Catalyzed Synthesis and an In Vitro Study against S. mansoni

Тип публикацииJournal Article
Дата публикации2023-06-22
scimago Q1
wos Q2
БС1
SJR0.865
CiteScore8.6
Impact factor4.6
ISSN14203049
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Краткое описание

A synthesis of bridged 1,2,4-trioxolanes (bridged ozonides) from 1,5-diketones and hydrogen peroxide catalyzed by SnCl4 was developed. It was shown that the ratio of target ozonides can be affected by the application of SnCl4 as a catalyst and varying the solvent. A wide range of bridged 1,2,4-trioxolanes (ozonides) was obtained in yields from 50 to 84%. The ozonide cycle was moderately resistant to the reduction of the ester group near the peroxide cycle to alcohol with LiAlH4. The bridged ozonides were evaluated for their antischistosomal activity. These ozonides exhibited a very high activity against newly transformed schistosomula and adult Schistosoma mansoni.

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Russian Chemical Reviews
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Advanced Synthesis and Catalysis
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Progress in Heterocyclic Chemistry
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ChemMedChem
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Organic and Biomolecular Chemistry
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Russian Journal of General Chemistry
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ГОСТ |
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Radulov P. S. et al. Bridged 1,2,4-Trioxolanes: SnCl4—Catalyzed Synthesis and an In Vitro Study against S. mansoni // Molecules. 2023. Vol. 28. No. 13. p. 4913.
ГОСТ со всеми авторами (до 50) Скопировать
Radulov P. S., Yaremenko I. A., Keiser J., Terent'ev A. O. Bridged 1,2,4-Trioxolanes: SnCl4—Catalyzed Synthesis and an In Vitro Study against S. mansoni // Molecules. 2023. Vol. 28. No. 13. p. 4913.
RIS |
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TY - JOUR
DO - 10.3390/molecules28134913
UR - https://www.mdpi.com/1420-3049/28/13/4913
TI - Bridged 1,2,4-Trioxolanes: SnCl4—Catalyzed Synthesis and an In Vitro Study against S. mansoni
T2 - Molecules
AU - Radulov, Peter S
AU - Yaremenko, Ivan A
AU - Keiser, J
AU - Terent'ev, Alexander O.
PY - 2023
DA - 2023/06/22
PB - MDPI
SP - 4913
IS - 13
VL - 28
PMID - 37446575
SN - 1420-3049
ER -
BibTex |
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BibTex (до 50 авторов) Скопировать
@article{2023_Radulov,
author = {Peter S Radulov and Ivan A Yaremenko and J Keiser and Alexander O. Terent'ev},
title = {Bridged 1,2,4-Trioxolanes: SnCl4—Catalyzed Synthesis and an In Vitro Study against S. mansoni},
journal = {Molecules},
year = {2023},
volume = {28},
publisher = {MDPI},
month = {jun},
url = {https://www.mdpi.com/1420-3049/28/13/4913},
number = {13},
pages = {4913},
doi = {10.3390/molecules28134913}
}
MLA
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Radulov, Peter S., et al. “Bridged 1,2,4-Trioxolanes: SnCl4—Catalyzed Synthesis and an In Vitro Study against S. mansoni.” Molecules, vol. 28, no. 13, Jun. 2023, p. 4913. https://www.mdpi.com/1420-3049/28/13/4913.