Open Access

Nanomaterials, volume 10, issue 9, pages 1646

Multifunctional Fe3O4-Au Nanoparticles for the MRI Diagnosis and Potential Treatment of Liver Cancer

Kozenkova Elena ¹

Levada Kateryna ¹

Efremova Maria V ^{2, 3, 4}

Omelyanchik Alexander ¹

Nalench Yulia A ⁴

Garanina Anastasiia S ^{2, 4}

Pshenichnikov Stanislav ¹

Zhukov Dmitry G. ⁴

Lunov Oleg ⁵

Lunova Mariia ⁶

Kozenkov Ivan ¹

Innocenti C. ^{7, 8}

Albino Martin ⁷

Abakumov Maxim A. ^{3, 4}

Sangregorio Claudio ^{1, 7, 8}

Rodionova Valeria ¹

Hide authors affiliations Show authors affiliations: 8 affiliations

Institute of Physics, Mathematics and Information Technology, Immanuel Kant Baltic Federal University, 236008 Kaliningrad, Russia |

Department of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia |

Department of Medical Nanobiotechnology, Russian National Research Medical University, 117997 Moscow, Russia |

⁴

Laboratory of Biomedical Nanomaterials, National University of Science and Technology “MISiS”, 119049 Moscow, Russia |

⁵

Institute of Physics of the Czech Academy of Sciences, 18200 Prague, Czech Republic |

⁶

Institute for Clinical & Experimental Medicine (IKEM), 14021 Prague, Czech Republic |

⁷

INSTM and Dept. of Chemistry, University of Florence, 50019 Sesto Fiorentino, Italy

University of Florence

National Interuniversity Consortium of Materials Science and Technology

⁸

Institute of Chemistry of Organometallic Compounds – C.N.R., 50019 Sesto Fiorentino, Italy |

Publication type: Journal Article

Publication date: 2020-08-21

Multidisciplinary Digital Publishing Institute (MDPI)

Journal: Nanomaterials

Quartile SCImago

Quartile WOS

Impact factor: 5.3

ISSN: 20794991

DOI: 10.3390/nano10091646

Copy DOI

PubMed ID: 32825748

General Chemical Engineering

General Materials Science

Abstract

Heterodimeric nanoparticles comprising materials with different functionalities are of great interest for fundamental research and biomedical/industrial applications. In this work, Fe3O4-Au nano-heterostructures were synthesized by a one-step thermal decomposition method. The hybrid nanoparticles comprise a highly crystalline 12 nm magnetite octahedron decorated with a single noble metal sphere of 6 nm diameter. Detailed analysis of the nanoparticles was performed by UV-visible spectroscopy, magnetometry, calorimetry and relaxometry studies. The cytotoxic effect of the nanoparticles in the human hepatic cell line Huh7 and PLC/PRF/5-Alexander was also assessed. These Fe3O4-Au bifunctional nanoparticles showed no significant cytotoxicity in these two cell lines. The nanoparticles showed a good theranostic potential for liver cancer treatment, since the r2 relaxivity (166.5 mM−1·s−1 and 99.5 mM−1·s−1 in water and HepG2 cells, respectively) is higher than the corresponding values for commercial T2 contrast agents and the Specific Absorption Rate (SAR) value obtained (227 W/gFe) is enough to make them suitable as heat mediators for Magnetic Fluid Hyperthermia. The gold counterpart can further allow the conjugation with different biomolecules and the optical sensing.

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Citations by journals

	1 2
Nanoscale	Nanoscale, 2, 7.41% Nanoscale 2 publications, 7.41%
Materials	Materials, 1, 3.7% Materials 1 publication, 3.7%
Pharmaceutics	Pharmaceutics, 1, 3.7% Pharmaceutics 1 publication, 3.7%
ACS applied materials & interfaces	ACS applied materials & interfaces, 1, 3.7% ACS applied materials & interfaces 1 publication, 3.7%
Anti-Cancer Agents in Medicinal Chemistry	Anti-Cancer Agents in Medicinal Chemistry, 1, 3.7% Anti-Cancer Agents in Medicinal Chemistry 1 publication, 3.7%
Nanomedicine	Nanomedicine, 1, 3.7% Nanomedicine 1 publication, 3.7%
Nanomaterials	Nanomaterials, 1, 3.7% Nanomaterials 1 publication, 3.7%
Journal of Clinical Medicine	Journal of Clinical Medicine, 1, 3.7% Journal of Clinical Medicine 1 publication, 3.7%
Processes	Processes, 1, 3.7% Processes 1 publication, 3.7%
Frontiers in Bioengineering and Biotechnology	Frontiers in Bioengineering and Biotechnology, 1, 3.7% Frontiers in Bioengineering and Biotechnology 1 publication, 3.7%
Nanoscale Research Letters	Nanoscale Research Letters, 1, 3.7% Nanoscale Research Letters 1 publication, 3.7%
Journal of Saudi Chemical Society	Journal of Saudi Chemical Society, 1, 3.7% Journal of Saudi Chemical Society 1 publication, 3.7%
Journal of Materials Science and Technology	Journal of Materials Science and Technology, 1, 3.7% Journal of Materials Science and Technology 1 publication, 3.7%
Artificial Organs	Artificial Organs, 1, 3.7% Artificial Organs 1 publication, 3.7%
ACS Applied Nano Materials	ACS Applied Nano Materials, 1, 3.7% ACS Applied Nano Materials 1 publication, 3.7%
Nanoscale Advances	Nanoscale Advances, 1, 3.7% Nanoscale Advances 1 publication, 3.7%
Journal of Mechanics in Medicine and Biology	Journal of Mechanics in Medicine and Biology, 1, 3.7% Journal of Mechanics in Medicine and Biology 1 publication, 3.7%
Oxidative Medicine and Cellular Longevity	Oxidative Medicine and Cellular Longevity, 1, 3.7% Oxidative Medicine and Cellular Longevity 1 publication, 3.7%
Journal of Superconductivity and Novel Magnetism	Journal of Superconductivity and Novel Magnetism, 1, 3.7% Journal of Superconductivity and Novel Magnetism 1 publication, 3.7%
Chemical Engineering and Technology	Chemical Engineering and Technology, 1, 3.7% Chemical Engineering and Technology 1 publication, 3.7%
Phase Transitions	Phase Transitions, 1, 3.7% Phase Transitions 1 publication, 3.7%
Journal of Functional Biomaterials	Journal of Functional Biomaterials, 1, 3.7% Journal of Functional Biomaterials 1 publication, 3.7%
Russian Journal of Inorganic Chemistry	Russian Journal of Inorganic Chemistry, 1, 3.7% Russian Journal of Inorganic Chemistry 1 publication, 3.7%
Journal of Alloys and Compounds	Journal of Alloys and Compounds, 1, 3.7% Journal of Alloys and Compounds 1 publication, 3.7%
ACS Omega	ACS Omega, 1, 3.7% ACS Omega 1 publication, 3.7%
	1 2

Citations by publishers

	1 2 3 4 5 6
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 6, 22.22% Multidisciplinary Digital Publishing Institute (MDPI) 6 publications, 22.22%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 3, 11.11% Royal Society of Chemistry (RSC) 3 publications, 11.11%
American Chemical Society (ACS)	American Chemical Society (ACS), 3, 11.11% American Chemical Society (ACS) 3 publications, 11.11%
Springer Nature	Springer Nature, 3, 11.11% Springer Nature 3 publications, 11.11%
Wiley	Wiley, 2, 7.41% Wiley 2 publications, 7.41%
Bentham Science	Bentham Science, 1, 3.7% Bentham Science 1 publication, 3.7%
Future Medicine	Future Medicine, 1, 3.7% Future Medicine 1 publication, 3.7%
Frontiers Media S.A.	Frontiers Media S.A., 1, 3.7% Frontiers Media S.A. 1 publication, 3.7%
King Saud University	King Saud University, 1, 3.7% King Saud University 1 publication, 3.7%
World Scientific	World Scientific, 1, 3.7% World Scientific 1 publication, 3.7%
Hindawi Limited	Hindawi Limited, 1, 3.7% Hindawi Limited 1 publication, 3.7%
Taylor & Francis	Taylor & Francis, 1, 3.7% Taylor & Francis 1 publication, 3.7%
Pleiades Publishing	Pleiades Publishing, 1, 3.7% Pleiades Publishing 1 publication, 3.7%
Elsevier	Elsevier, 1, 3.7% Elsevier 1 publication, 3.7%
	1 2 3 4 5 6

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Kozenkova E. et al. Multifunctional Fe3O4-Au Nanoparticles for the MRI Diagnosis and Potential Treatment of Liver Cancer // Nanomaterials. 2020. Vol. 10. No. 9. p. 1646.

GOST all authors (up to 50) Copy

Kozenkova E., Levada K., Efremova M. V., Omelyanchik A., Nalench Y. A., Garanina A. S., Pshenichnikov S., Zhukov D. G., Lunov O., Lunova M., Kozenkov I., Innocenti C., Albino M., Abakumov M. A., Sangregorio C., Rodionova V. Multifunctional Fe3O4-Au Nanoparticles for the MRI Diagnosis and Potential Treatment of Liver Cancer // Nanomaterials. 2020. Vol. 10. No. 9. p. 1646.

RIS |

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RIS Copy

TY - JOUR

DO - 10.3390/nano10091646

UR - https://doi.org/10.3390%2Fnano10091646

TI - Multifunctional Fe3O4-Au Nanoparticles for the MRI Diagnosis and Potential Treatment of Liver Cancer

T2 - Nanomaterials

AU - Efremova, Maria V

AU - Nalench, Yulia A

AU - Garanina, Anastasiia S

AU - Pshenichnikov, Stanislav

AU - Zhukov, Dmitry G.

AU - Lunova, Mariia

AU - Abakumov, Maxim A.

AU - Levada, Kateryna

AU - Kozenkova, Elena

AU - Omelyanchik, Alexander

AU - Lunov, Oleg

AU - Kozenkov, Ivan

AU - Innocenti, C.

AU - Albino, Martin

AU - Sangregorio, Claudio

AU - Rodionova, Valeria

PY - 2020

DA - 2020/08/21 00:00:00

PB - Multidisciplinary Digital Publishing Institute (MDPI)

SP - 1646

IS - 9

VL - 10

PMID - 32825748

SN - 2079-4991

ER -

BibTex |

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BibTex Copy

@article{2020_Kozenkova,

author = {Maria V Efremova and Yulia A Nalench and Anastasiia S Garanina and Stanislav Pshenichnikov and Dmitry G. Zhukov and Mariia Lunova and Maxim A. Abakumov and Kateryna Levada and Elena Kozenkova and Alexander Omelyanchik and Oleg Lunov and Ivan Kozenkov and C. Innocenti and Martin Albino and Claudio Sangregorio and Valeria Rodionova},

title = {Multifunctional Fe3O4-Au Nanoparticles for the MRI Diagnosis and Potential Treatment of Liver Cancer},

journal = {Nanomaterials},

year = {2020},

volume = {10},

publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},

month = {aug},

url = {https://doi.org/10.3390%2Fnano10091646},

number = {9},

pages = {1646},

doi = {10.3390/nano10091646}

}

MLA

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MLA Copy

Kozenkova, Elena, et al. “Multifunctional Fe3O4-Au Nanoparticles for the MRI Diagnosis and Potential Treatment of Liver Cancer.” Nanomaterials, vol. 10, no. 9, Aug. 2020, p. 1646. https://doi.org/10.3390%2Fnano10091646.

Found error?

Publisher

Multidisciplinary Digital Publishing Institute (MDPI)

Journal

Nanomaterials

Quartile SCImago

Quartile WOS

Impact factor

5.3

ISSN

20794991 (Electronic)

Labs

Biomedical Nanomaterials Laboratory

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