Open Access
Nanomaterials, volume 12, issue 1, pages 38
Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity
Garanina A. S.
1
,
Nikitin Alexey A
1
,
Semkina Alevtina S.
3, 4
,
Prelovskaya Alexandra O
1
,
Naumenko Victor A
3
,
Erofeev Alexander S.
1, 5
,
Gorelkin Peter
6
,
Majouga Alexander G.
1, 5, 7
,
Abakumov Maxim A.
1, 4
,
Wiedwald U.
1, 8
6
Medical Nanotechnology LLC, Skolkovo Innovation Center, 121205 Moscow, Russia
|
8
Center for Nanointegration Duisburg-Essen, Faculty of Physics, University of Duisburg-Essen, 47057 Duisburg, Germany
|
Publication type: Journal Article
Publication date: 2021-12-23
PubMed ID:
35009988
General Chemical Engineering
General Materials Science
Abstract
Magnetic nanoparticles (MNPs) are widely considered for cancer treatment, in particular for magnetic hyperthermia (MHT). Thereby, MNPs are still being optimized for lowest possible toxicity on organisms while the magnetic properties are matched for best heating capabilities. In this study, the biocompatibility of 12 nm cobalt ferrite MNPs, functionalized with citrate ions, in different dosages on mice and rats of both sexes was investigated for 30 days after intraperitoneal injection. The animals’ weight, behavior, and blood cells changes, as well as blood biochemical parameters are correlated to histological examination of organs revealing that cobalt ferrite MNPs do not have toxic effects at concentrations close to those used previously for efficient MHT. Moreover, these MNPs demonstrated high specific loss power (SLP) of about 400 W g−1. Importantly the MNPs retained their magnetic properties inside tumor tissue after intratumoral administration for several MHT cycles within three days. Thus, cobalt ferrite MNPs represent a perspective platform for tumor therapy by MHT due to their ability to provide effective heating without exerting a toxic effect on the organism. This opens up new avenues for smaller MNPs sizes while their heating efficiency is maintained.
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Citations by publishers
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1
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Elsevier
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8 publications, 47.06%
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8
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Garanina A. S. et al. Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity // Nanomaterials. 2021. Vol. 12. No. 1. p. 38.
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Garanina A. S., Nikitin A. A., Abakumova T. O., Semkina A. S., Prelovskaya A. O., Naumenko V. A., Erofeev A. S., Gorelkin P., Majouga A. G., Abakumov M. A., Wiedwald U. Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity // Nanomaterials. 2021. Vol. 12. No. 1. p. 38.
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TY - JOUR
DO - 10.3390/nano12010038
UR - https://doi.org/10.3390%2Fnano12010038
TI - Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity
T2 - Nanomaterials
AU - Nikitin, Alexey A
AU - Semkina, Alevtina S.
AU - Prelovskaya, Alexandra O
AU - Naumenko, Victor A
AU - Erofeev, Alexander S.
AU - Majouga, Alexander G.
AU - Abakumova, Tatiana O
AU - Garanina, A. S.
AU - Gorelkin, Peter
AU - Abakumov, Maxim A.
AU - Wiedwald, U.
PY - 2021
DA - 2021/12/23 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 38
IS - 1
VL - 12
PMID - 35009988
SN - 2079-4991
ER -
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@article{2021_Garanina,
author = {Alexey A Nikitin and Alevtina S. Semkina and Alexandra O Prelovskaya and Victor A Naumenko and Alexander S. Erofeev and Alexander G. Majouga and Tatiana O Abakumova and A. S. Garanina and Peter Gorelkin and Maxim A. Abakumov and U. Wiedwald},
title = {Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity},
journal = {Nanomaterials},
year = {2021},
volume = {12},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {dec},
url = {https://doi.org/10.3390%2Fnano12010038},
number = {1},
pages = {38},
doi = {10.3390/nano12010038}
}
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MLA
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Garanina, A. S., et al. “Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity.” Nanomaterials, vol. 12, no. 1, Dec. 2021, p. 38. https://doi.org/10.3390%2Fnano12010038.