Open Access
Nanomaterials, volume 12, issue 3, pages 361
Mechanisms of Formation, Structure, and Dynamics of Lipoprotein Discs Stabilized by Amphiphilic Copolymers: A Comprehensive Review
Orekhov Philipp
1, 2, 3
,
Bozdaganyan Marine E
2, 3, 4
,
Voskoboynikova Natalia
5
,
Mulkidjanian Armen Y
5, 6
,
Karlova Maria G.
3
,
Yudenko Anna N.
7
,
Remeeva Alina
7
,
Ryzhykau Yury L.
7
,
Gushchin Ivan
7
,
Gordeliy Valentin I
7, 8, 9, 10
,
Sokolova Olga S.
2, 3
,
Steinhoff H.
5
,
Kirpichnikov Mikhail P.
3, 11
,
Shaitan Konstantin V.
3
5
Department of Physics, University of Osnabrück, Barbarastrasse 7, 49076 Osnabrück, Germany
|
8
JuStruct: Jülich Center for Structural Biology, Forschungszentrum Jülich, 52428 Jülich, Germany
|
10
Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich, 52428 Jülich, Germany
|
Publication type: Journal Article
Publication date: 2022-01-23
General Chemical Engineering
General Materials Science
Abstract
Amphiphilic copolymers consisting of alternating hydrophilic and hydrophobic units account for a major recent methodical breakthrough in the investigations of membrane proteins. Styrene–maleic acid (SMA), diisobutylene–maleic acid (DIBMA), and related copolymers have been shown to extract membrane proteins directly from lipid membranes without the need for classical detergents. Within the particular experimental setup, they form disc-shaped nanoparticles with a narrow size distribution, which serve as a suitable platform for diverse kinds of spectroscopy and other biophysical techniques that require relatively small, homogeneous, water-soluble particles of separate membrane proteins in their native lipid environment. In recent years, copolymer-encased nanolipoparticles have been proven as suitable protein carriers for various structural biology applications, including cryo-electron microscopy (cryo-EM), small-angle scattering, and conventional and single-molecule X-ray diffraction experiments. Here, we review the current understanding of how such nanolipoparticles are formed and organized at the molecular level with an emphasis on their chemical diversity and factors affecting their size and solubilization efficiency.
Citations by journals
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1
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Langmuir
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Langmuir
1 publication, 10%
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Scientific Reports
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Scientific Reports
1 publication, 10%
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Biochimie
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Analytical Chemistry
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Russian Journal of Physical Chemistry B
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1 publication, 10%
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Angewandte Chemie - International Edition
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Angewandte Chemie - International Edition
1 publication, 10%
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Angewandte Chemie
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Angewandte Chemie
1 publication, 10%
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Soft Matter
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Soft Matter
1 publication, 10%
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Archives of Biochemistry and Biophysics
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Archives of Biochemistry and Biophysics
1 publication, 10%
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1
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Citations by publishers
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1
2
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American Chemical Society (ACS)
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American Chemical Society (ACS)
2 publications, 20%
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Elsevier
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Elsevier
2 publications, 20%
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Wiley
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Wiley
2 publications, 20%
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Springer Nature
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Springer Nature
1 publication, 10%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 10%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
1 publication, 10%
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1
2
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Orekhov P. et al. Mechanisms of Formation, Structure, and Dynamics of Lipoprotein Discs Stabilized by Amphiphilic Copolymers: A Comprehensive Review // Nanomaterials. 2022. Vol. 12. No. 3. p. 361.
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Orekhov P., Bozdaganyan M. E., Voskoboynikova N., Mulkidjanian A. Y., Karlova M. G., Yudenko A. N., Remeeva A., Ryzhykau Y. L., Gushchin I., Gordeliy V. I., Sokolova O. S., Steinhoff H., Kirpichnikov M. P., Shaitan K. V. Mechanisms of Formation, Structure, and Dynamics of Lipoprotein Discs Stabilized by Amphiphilic Copolymers: A Comprehensive Review // Nanomaterials. 2022. Vol. 12. No. 3. p. 361.
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TY - JOUR
DO - 10.3390/nano12030361
UR - https://doi.org/10.3390%2Fnano12030361
TI - Mechanisms of Formation, Structure, and Dynamics of Lipoprotein Discs Stabilized by Amphiphilic Copolymers: A Comprehensive Review
T2 - Nanomaterials
AU - Bozdaganyan, Marine E
AU - Karlova, Maria G.
AU - Gordeliy, Valentin I
AU - Kirpichnikov, Mikhail P.
AU - Shaitan, Konstantin V.
AU - Mulkidjanian, Armen Y
AU - Voskoboynikova, Natalia
AU - Orekhov, Philipp
AU - Yudenko, Anna N.
AU - Remeeva, Alina
AU - Ryzhykau, Yury L.
AU - Gushchin, Ivan
AU - Sokolova, Olga S.
AU - Steinhoff, H.
PY - 2022
DA - 2022/01/23 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 361
IS - 3
VL - 12
SN - 2079-4991
ER -
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@article{2022_Orekhov,
author = {Marine E Bozdaganyan and Maria G. Karlova and Valentin I Gordeliy and Mikhail P. Kirpichnikov and Konstantin V. Shaitan and Armen Y Mulkidjanian and Natalia Voskoboynikova and Philipp Orekhov and Anna N. Yudenko and Alina Remeeva and Yury L. Ryzhykau and Ivan Gushchin and Olga S. Sokolova and H. Steinhoff},
title = {Mechanisms of Formation, Structure, and Dynamics of Lipoprotein Discs Stabilized by Amphiphilic Copolymers: A Comprehensive Review},
journal = {Nanomaterials},
year = {2022},
volume = {12},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jan},
url = {https://doi.org/10.3390%2Fnano12030361},
number = {3},
pages = {361},
doi = {10.3390/nano12030361}
}
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Orekhov, Philipp, et al. “Mechanisms of Formation, Structure, and Dynamics of Lipoprotein Discs Stabilized by Amphiphilic Copolymers: A Comprehensive Review.” Nanomaterials, vol. 12, no. 3, Jan. 2022, p. 361. https://doi.org/10.3390%2Fnano12030361.