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Open access
MDPI
Nanomaterials
,  volume 12 ,  issue 7 ,  pages 1126

A Comparison of the Genotoxic Effects of Gold Nanoparticles Functionalized with Seven Different Ligands in Cultured Human Hepatocellular Carcinoma Cells

Publication type: Journal Article
Publication date: 2022-03-29
MDPI
scimago Q1
wos Q2
SJR: 0.811
CiteScore: 9.2
Impact factor: 4.3
ISSN: 20794991
DOI:  10.3390/nano12071126
PubMed ID:  35407243
General Chemical Engineering
General Materials Science
Abstract

Gold nanoparticles (GNPs) have shown great potential in diagnostic and therapeutic applications in diseases, such as cancer. Despite GNP versatility, there is conflicting data regarding the toxicity of their overall functionalization chemistry for improved biocompatibility. This study aimed to determine the possible genotoxic effects of functionalized GNPs in Human hepatocellular carcinoma (HepG2) cells. GNPs were synthesized and biofunctionalized with seven common molecules used for biomedical applications. These ligands were bovine serum albumin (BSA), poly(sodium 4-styrene sulfonate) (PSSNA), trisodium citrate (citrate), mercaptoundecanoic acid (MUA), glutathione (GSH), polyvinylpyrrolidone (PVP), and polyethylene glycol (PEG). Before in vitro genotoxicity assessment, inductively coupled plasma mass spectrometry was used to determine GNP cellular internalization quantitatively, followed by cell-based assays; WST-1 to find IC 30 and ApoPercentage for apoptotic induction time-points. The effect of the GNPs on cell growth in real-time was determined by using xCELLigence, followed by a comet assay for genotoxicity determination. The HepG2 cells experienced genotoxicity for all GNP ligands; however, they were able to initiate repair mechanisms and recover DNA damage, except for two functionalization chemistries.

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GOST Copy
Mulder D. W. et al. A Comparison of the Genotoxic Effects of Gold Nanoparticles Functionalized with Seven Different Ligands in Cultured Human Hepatocellular Carcinoma Cells // Nanomaterials. 2022. Vol. 12. No. 7. p. 1126.
GOST all authors (up to 50) Copy
Mulder D. W., Taute F., Van Wyk M., Pretorius P. J. A Comparison of the Genotoxic Effects of Gold Nanoparticles Functionalized with Seven Different Ligands in Cultured Human Hepatocellular Carcinoma Cells // Nanomaterials. 2022. Vol. 12. No. 7. p. 1126.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.3390/nano12071126
UR - https://doi.org/10.3390/nano12071126
TI - A Comparison of the Genotoxic Effects of Gold Nanoparticles Functionalized with Seven Different Ligands in Cultured Human Hepatocellular Carcinoma Cells
T2 - Nanomaterials
AU - Mulder, Danielle Wingrove
AU - Taute, Francois
AU - Van Wyk, Mari
AU - Pretorius, Pieter J
PY - 2022
DA - 2022/03/29
PB - MDPI
SP - 1126
IS - 7
VL - 12
PMID - 35407243
SN - 2079-4991
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2022_Mulder,
author = {Danielle Wingrove Mulder and Francois Taute and Mari Van Wyk and Pieter J Pretorius},
title = {A Comparison of the Genotoxic Effects of Gold Nanoparticles Functionalized with Seven Different Ligands in Cultured Human Hepatocellular Carcinoma Cells},
journal = {Nanomaterials},
year = {2022},
volume = {12},
publisher = {MDPI},
month = {mar},
url = {https://doi.org/10.3390/nano12071126},
number = {7},
pages = {1126},
doi = {10.3390/nano12071126}
}
MLA
Cite this
MLA Copy
Mulder, Danielle Wingrove, et al. “A Comparison of the Genotoxic Effects of Gold Nanoparticles Functionalized with Seven Different Ligands in Cultured Human Hepatocellular Carcinoma Cells.” Nanomaterials, vol. 12, no. 7, Mar. 2022, p. 1126. https://doi.org/10.3390/nano12071126.