Open Access
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Nanomaterials, volume 12, issue 10, pages 1657

New Approach to Non-Invasive Tumor Model Monitoring via Self-Assemble Iron Containing Protein Nanocompartments

Efremova Maria V 3, 4, 5
Oda Vera V. 1
Sarkisova Viktoria A. 6, 8
Semkina Alevtina S. 7, 9
Ivanova Anna V. 1
Publication typeJournal Article
Publication date2022-05-12
Journal: Nanomaterials
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor5.3
ISSN20794991
PubMed ID:  35630878
General Chemical Engineering
General Materials Science
Abstract

According to the World Health Organization, breast cancer is the most common oncological disease worldwide. There are multiple animal models for different types of breast carcinoma, allowing the research of tumor growth, metastasis, and angiogenesis. When studying these processes, it is crucial to visualize cancer cells for a prolonged time via a non-invasive method, for example, magnetic resonance imaging (MRI). In this study, we establish a new genetically encoded material based on Quasibacillus thermotolerans (Q.thermotolerans, Qt) encapsulin, stably expressed in mouse 4T1 breast carcinoma cells. The label consists of a protein shell containing an enzyme called ferroxidase. When adding Fe2+, a ferroxidase oxidizes Fe2+ to Fe3+, followed by iron oxide nanoparticles formation. Additionally, genes encoding mZip14 metal transporter, enhancing the iron transport, were inserted into the cells via lentiviral transduction. The expression of transgenic sequences does not affect cell viability, and the presence of magnetic nanoparticles formed inside encapsulins results in an increase in T2 relaxivity.

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Citations by publishers

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Gabashvili A. N. et al. New Approach to Non-Invasive Tumor Model Monitoring via Self-Assemble Iron Containing Protein Nanocompartments // Nanomaterials. 2022. Vol. 12. No. 10. p. 1657.
GOST all authors (up to 50) Copy
Gabashvili A. N., Efremova M. V., Vodopyanov S. S., Chmelyuk N. S., Oda V. V., Sarkisova V. A., Leonova M. K., Semkina A. S., Ivanova A. V., Abakumov M. A. New Approach to Non-Invasive Tumor Model Monitoring via Self-Assemble Iron Containing Protein Nanocompartments // Nanomaterials. 2022. Vol. 12. No. 10. p. 1657.
RIS |
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RIS Copy
TY - JOUR
DO - 10.3390/nano12101657
UR - https://doi.org/10.3390%2Fnano12101657
TI - New Approach to Non-Invasive Tumor Model Monitoring via Self-Assemble Iron Containing Protein Nanocompartments
T2 - Nanomaterials
AU - Chmelyuk, Nelly S.
AU - Oda, Vera V.
AU - Sarkisova, Viktoria A.
AU - Semkina, Alevtina S.
AU - Ivanova, Anna V.
AU - Efremova, Maria V
AU - Gabashvili, Anna N.
AU - Vodopyanov, Stepan S
AU - Leonova, Maria K
AU - Abakumov, Maxim A.
PY - 2022
DA - 2022/05/12 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 1657
IS - 10
VL - 12
PMID - 35630878
SN - 2079-4991
ER -
BibTex |
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BibTex Copy
@article{2022_Gabashvili
author = {Nelly S. Chmelyuk and Vera V. Oda and Viktoria A. Sarkisova and Alevtina S. Semkina and Anna V. Ivanova and Maria V Efremova and Anna N. Gabashvili and Stepan S Vodopyanov and Maria K Leonova and Maxim A. Abakumov},
title = {New Approach to Non-Invasive Tumor Model Monitoring via Self-Assemble Iron Containing Protein Nanocompartments},
journal = {Nanomaterials},
year = {2022},
volume = {12},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {may},
url = {https://doi.org/10.3390%2Fnano12101657},
number = {10},
pages = {1657},
doi = {10.3390/nano12101657}
}
MLA
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MLA Copy
Gabashvili, Anna N., et al. “New Approach to Non-Invasive Tumor Model Monitoring via Self-Assemble Iron Containing Protein Nanocompartments.” Nanomaterials, vol. 12, no. 10, May. 2022, p. 1657. https://doi.org/10.3390%2Fnano12101657.
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