Open Access
Lithographic SERS Aptasensor for Ultrasensitive Detection of SARS-CoV-2 in Biological Fluids
Vladimir Kukushkin
1
,
Oganes Ambartsumyan
2
,
Anna Astrakhantseva
1, 3
,
В. А. Гущин
4
,
Alexandra Nikonova
5
,
Anastasia Dorofeeva
5
,
Vitaly Zverev
2, 5
,
Alexandra Gambaryan
6
,
Daria Tikhonova
1, 7
,
Assel Akhmetova
8
,
Igor Yaminsky
8
,
1
Publication type: Journal Article
Publication date: 2022-11-01
PubMed ID:
36364630
General Chemical Engineering
General Materials Science
Abstract
In this paper, we propose a technology for the rapid and sensitive detection of the whole viral particles of SARS-CoV-2 using double-labeled DNA aptamers as recognition elements together with the SERS method for detecting the optical response. We report on the development of a SERS-aptasensor based on a reproducible lithographic SERS substrate, featuring the combination of high speed, specificity, and ultrasensitive quantitative detection of SARS-CoV-2 virions. The sensor makes it possible to identify SARS-CoV-2 in very low concentrations (the limit of detection was 100 copies/mL), demonstrating a sensitivity level comparable to the existing diagnostic golden standard—the reverse transcription polymerase chain reaction.
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Metrics
9
Total citations:
9
Citations from 2024:
6
(66.66%)
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RIS |
BibTex |
MLA
Cite this
GOST
Copy
Kukushkin V. et al. Lithographic SERS Aptasensor for Ultrasensitive Detection of SARS-CoV-2 in Biological Fluids // Nanomaterials. 2022. Vol. 12. No. 21. p. 3854.
GOST all authors (up to 50)
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Kukushkin V., Ambartsumyan O., Astrakhantseva A., Гущин В. А., Nikonova A., Dorofeeva A., Zverev V., Gambaryan A., Tikhonova D., Sovetnikov T., Akhmetova A., Yaminsky I., Zavyalova E. Lithographic SERS Aptasensor for Ultrasensitive Detection of SARS-CoV-2 in Biological Fluids // Nanomaterials. 2022. Vol. 12. No. 21. p. 3854.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/nano12213854
UR - https://www.mdpi.com/2079-4991/12/21/3854
TI - Lithographic SERS Aptasensor for Ultrasensitive Detection of SARS-CoV-2 in Biological Fluids
T2 - Nanomaterials
AU - Kukushkin, Vladimir
AU - Ambartsumyan, Oganes
AU - Astrakhantseva, Anna
AU - Гущин, В. А.
AU - Nikonova, Alexandra
AU - Dorofeeva, Anastasia
AU - Zverev, Vitaly
AU - Gambaryan, Alexandra
AU - Tikhonova, Daria
AU - Sovetnikov, Timofei
AU - Akhmetova, Assel
AU - Yaminsky, Igor
AU - Zavyalova, Elena
PY - 2022
DA - 2022/11/01
PB - MDPI
SP - 3854
IS - 21
VL - 12
PMID - 36364630
SN - 2079-4991
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2022_Kukushkin,
author = {Vladimir Kukushkin and Oganes Ambartsumyan and Anna Astrakhantseva and В. А. Гущин and Alexandra Nikonova and Anastasia Dorofeeva and Vitaly Zverev and Alexandra Gambaryan and Daria Tikhonova and Timofei Sovetnikov and Assel Akhmetova and Igor Yaminsky and Elena Zavyalova},
title = {Lithographic SERS Aptasensor for Ultrasensitive Detection of SARS-CoV-2 in Biological Fluids},
journal = {Nanomaterials},
year = {2022},
volume = {12},
publisher = {MDPI},
month = {nov},
url = {https://www.mdpi.com/2079-4991/12/21/3854},
number = {21},
pages = {3854},
doi = {10.3390/nano12213854}
}
Cite this
MLA
Copy
Kukushkin, Vladimir, et al. “Lithographic SERS Aptasensor for Ultrasensitive Detection of SARS-CoV-2 in Biological Fluids.” Nanomaterials, vol. 12, no. 21, Nov. 2022, p. 3854. https://www.mdpi.com/2079-4991/12/21/3854.