Open Access
Understanding the Origin of the Regioselectivity in Non-Polar [3+2] Cycloaddition Reactions through the Molecular Electron Density Theory
Publication type: Journal Article
Publication date: 2020-11-13
Industrial and Manufacturing Engineering
Abstract
The regioselectivity in non-polar [3+2] cycloaddition (32CA) reactions has been studied within the Molecular Electron Density Theory (MEDT) at the B3LYP/6-311G(d,p) level. To this end, the 32CA reactions of nine simplest three-atom-components (TACs) with 2-methylpropene were selected. The electronic structure of the reagents has been characterized through the Electron Localisation Function (ELF) and the Conceptual DFT. The energy profiles of the two regioisomeric reaction paths and ELF topology of the transition state structures are studied to understand the origin of the regioselectivity in these 32CA reactions. This MEDT study permits to conclude that the least electronegative X1 end atom of these TACs controls the asynchronicity in the C−X (X=C, N, O) single bond formation, and consequently, the regioselectivity. This behaviour is a consequence of the fact that the creation of the non-bonding electron density required for the formation of the new single bonds has a lower energy demand at the least electronegative X1 atom than at the Z3 one.
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Domingo L. R. et al. Understanding the Origin of the Regioselectivity in Non-Polar [3+2] Cycloaddition Reactions through the Molecular Electron Density Theory // Organics. 2020. Vol. 1. No. 1. pp. 19-35.
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Domingo L. R., Ríos Gutiérrez M., Castellanos Soriano J. Understanding the Origin of the Regioselectivity in Non-Polar [3+2] Cycloaddition Reactions through the Molecular Electron Density Theory // Organics. 2020. Vol. 1. No. 1. pp. 19-35.
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TY - JOUR
DO - 10.3390/org1010003
UR - https://doi.org/10.3390/org1010003
TI - Understanding the Origin of the Regioselectivity in Non-Polar [3+2] Cycloaddition Reactions through the Molecular Electron Density Theory
T2 - Organics
AU - Domingo, Luis R.
AU - Ríos Gutiérrez, Mar
AU - Castellanos Soriano, Jorge
PY - 2020
DA - 2020/11/13
PB - MDPI
SP - 19-35
IS - 1
VL - 1
SN - 2673-401X
ER -
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@article{2020_Domingo,
author = {Luis R. Domingo and Mar Ríos Gutiérrez and Jorge Castellanos Soriano},
title = {Understanding the Origin of the Regioselectivity in Non-Polar [3+2] Cycloaddition Reactions through the Molecular Electron Density Theory},
journal = {Organics},
year = {2020},
volume = {1},
publisher = {MDPI},
month = {nov},
url = {https://doi.org/10.3390/org1010003},
number = {1},
pages = {19--35},
doi = {10.3390/org1010003}
}
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MLA
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Domingo, Luis R., et al. “Understanding the Origin of the Regioselectivity in Non-Polar [3+2] Cycloaddition Reactions through the Molecular Electron Density Theory.” Organics, vol. 1, no. 1, Nov. 2020, pp. 19-35. https://doi.org/10.3390/org1010003.