Open Access
The i-Motif as a Molecular Target: More Than a Complementary DNA Secondary Structure
Publication type: Journal Article
Publication date: 2021-01-27
PubMed ID:
33513764
Drug Discovery
Pharmaceutical Science
Molecular Medicine
Abstract
Stretches of cytosine-rich DNA are capable of adopting a dynamic secondary structure, the i-motif. When within promoter regions, the i-motif has the potential to act as a molecular switch for controlling gene expression. However, i-motif structures in genomic areas of repetitive nucleotide sequences may play a role in facilitating or hindering expansion of these DNA elements. Despite research on the i-motif trailing behind the complementary G-quadruplex structure, recent discoveries including the identification of a specific i-motif antibody are pushing this field forward. This perspective reviews initial and current work characterizing the i-motif and providing insight into the biological function of this DNA structure, with a focus on how the i-motif can serve as a molecular target for developing new therapeutic approaches to modulate gene expression and extension of repetitive DNA.
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83
Total citations:
83
Citations from 2024:
39
(46.99%)
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GOST
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Brown S. L., Kendrick S. The i-Motif as a Molecular Target: More Than a Complementary DNA Secondary Structure // Pharmaceuticals. 2021. Vol. 14. No. 2. p. 96.
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Brown S. L., Kendrick S. The i-Motif as a Molecular Target: More Than a Complementary DNA Secondary Structure // Pharmaceuticals. 2021. Vol. 14. No. 2. p. 96.
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RIS
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TY - JOUR
DO - 10.3390/ph14020096
UR - https://doi.org/10.3390/ph14020096
TI - The i-Motif as a Molecular Target: More Than a Complementary DNA Secondary Structure
T2 - Pharmaceuticals
AU - Brown, Susie L.
AU - Kendrick, Samantha
PY - 2021
DA - 2021/01/27
PB - MDPI
SP - 96
IS - 2
VL - 14
PMID - 33513764
SN - 1424-8247
ER -
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BibTex (up to 50 authors)
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@article{2021_Brown,
author = {Susie L. Brown and Samantha Kendrick},
title = {The i-Motif as a Molecular Target: More Than a Complementary DNA Secondary Structure},
journal = {Pharmaceuticals},
year = {2021},
volume = {14},
publisher = {MDPI},
month = {jan},
url = {https://doi.org/10.3390/ph14020096},
number = {2},
pages = {96},
doi = {10.3390/ph14020096}
}
Cite this
MLA
Copy
Brown, Susie L., and Samantha Kendrick. “The i-Motif as a Molecular Target: More Than a Complementary DNA Secondary Structure.” Pharmaceuticals, vol. 14, no. 2, Jan. 2021, p. 96. https://doi.org/10.3390/ph14020096.