Open Access
Pharmaceuticals, volume 14, issue 7, pages 610
Pharmacokinetic Study of Anti-osteoarthritic Compounds of a Standardized Fraction from Sphaeralcea Angustifolia
Serrano-Román Jade
1, 2
,
Nicasio Torres Pilar
1
,
Hernández Pérez Elizabeth
2
,
Jiménez-Ferrer Enrique
1
1
Centro de Investigación Biomédica del Sur (CIBIS), Instituto Mexicano del Seguro Social (IMSS), Argentina 1, Centro, Xochitepec CP 62790, Mexico
|
2
Doctorado en Ciencias Biológicas y de la Salud, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana Unidad Iztapalapa (UAM-Iztapalapa). San Rafael Atlixco 186, Vicentina, Iztapalapa, Ciudad de Mexico CP 09340, Mexico
|
Publication type: Journal Article
Publication date: 2021-06-25
PubMed ID:
34202137
Drug Discovery
Pharmaceutical Science
Molecular Medicine
Abstract
Sphaeralcea angustifolia has been widely used in inflammatory conditions such as blows, bruises, fractures, and wounds. The compounds identified as active in plants and suspension cell culture of S. angustifolia were tomentin, scopoletin, and sphaeralcic acid. To consolidate the integral use of knowledge about the S. angunstifolia and strengthen its pharmacological use in patients with knee osteoarthritis, the pharmacokinetic behavior of the active compounds was characterized. The SaTSS (S. angustifoloia standardized in Tomentin, Scopoletin, and Sphaeralcic acid) anti-ostearthritic fraction was obtained from cell suspension. The analytical method of High-Performance Liquid Chromatography (HPLC) for tomentin, scopoletin, and sphaeralcic acid were validated determining the accuracy, precision linearity, sensibility, specificity, detection limits, and quantification time-range parameters, as well as extraction efficiency and stability of compounds. The pharmacokinetic assay was performed with ICR mice strain, in which the mice were administrated with a single oral or intravenous dose (400 mg/kg with 7.1 mg/kg of scopoletin and tomentin in mixture and 34.6 mg/kg of sphaeralcic acid) of the SaTSS standardized active fraction. The results of the validated analytical methods allowed establishing, in a validated manner, that a coumarin mixture and sphaeralcic acid present in the SaTES fraction were detected in plasma. According to the values of Akaike Information Criteria (AIC), Sum of Squares (SS), Schwarz Criteria (SC), and by the determination coefficient (R2), the compounds follow a two-compartment model.
Citations by journals
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1
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
1 publication, 20%
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Plants
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Plants
1 publication, 20%
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Revista Brasileira de Farmacognosia
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Revista Brasileira de Farmacognosia
1 publication, 20%
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Journal of Food Biochemistry
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Journal of Food Biochemistry
1 publication, 20%
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1
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Citations by publishers
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1
2
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 40%
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Springer Nature
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Springer Nature
1 publication, 20%
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Wiley
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Wiley
1 publication, 20%
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Research Square Platform LLC
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Research Square Platform LLC, 1, 20%
Research Square Platform LLC
1 publication, 20%
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1
2
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Serrano-Román J. et al. Pharmacokinetic Study of Anti-osteoarthritic Compounds of a Standardized Fraction from Sphaeralcea Angustifolia // Pharmaceuticals. 2021. Vol. 14. No. 7. p. 610.
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Serrano-Román J., Nicasio Torres P., Hernández Pérez E., Jiménez-Ferrer E. Pharmacokinetic Study of Anti-osteoarthritic Compounds of a Standardized Fraction from Sphaeralcea Angustifolia // Pharmaceuticals. 2021. Vol. 14. No. 7. p. 610.
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TY - JOUR
DO - 10.3390/ph14070610
UR - https://doi.org/10.3390%2Fph14070610
TI - Pharmacokinetic Study of Anti-osteoarthritic Compounds of a Standardized Fraction from Sphaeralcea Angustifolia
T2 - Pharmaceuticals
AU - Serrano-Román, Jade
AU - Nicasio Torres, Pilar
AU - Hernández Pérez, Elizabeth
AU - Jiménez-Ferrer, Enrique
PY - 2021
DA - 2021/06/25 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 610
IS - 7
VL - 14
PMID - 34202137
SN - 1424-8247
ER -
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@article{2021_Serrano-Román,
author = {Jade Serrano-Román and Pilar Nicasio Torres and Elizabeth Hernández Pérez and Enrique Jiménez-Ferrer},
title = {Pharmacokinetic Study of Anti-osteoarthritic Compounds of a Standardized Fraction from Sphaeralcea Angustifolia},
journal = {Pharmaceuticals},
year = {2021},
volume = {14},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jun},
url = {https://doi.org/10.3390%2Fph14070610},
number = {7},
pages = {610},
doi = {10.3390/ph14070610}
}
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Serrano-Román, Jade, et al. “Pharmacokinetic Study of Anti-osteoarthritic Compounds of a Standardized Fraction from Sphaeralcea Angustifolia.” Pharmaceuticals, vol. 14, no. 7, Jun. 2021, p. 610. https://doi.org/10.3390%2Fph14070610.