Open Access
New Applications of Lipid and Polymer-Based Nanoparticles for Nucleic Acids Delivery
3
Academy of Romanian Scientists, Ilfov No. 3, 50044 Bucharest, Romania
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Publication type: Journal Article
Publication date: 2021-12-01
PubMed ID:
34959335
Pharmaceutical Science
Abstract
Nucleic acids represent a promising lead for engineering the immune system. However, naked DNA, mRNA, siRNA, and other nucleic acids are prone to enzymatic degradation and face challenges crossing the cell membrane. Therefore, increasing research has been recently focused on developing novel delivery systems that are able to overcome these drawbacks. Particular attention has been drawn to designing lipid and polymer-based nanoparticles that protect nucleic acids and ensure their targeted delivery, controlled release, and enhanced cellular uptake. In this respect, this review aims to present the recent advances in the field, highlighting the possibility of using these nanosystems for therapeutic and prophylactic purposes towards combatting a broad range of infectious, chronic, and genetic disorders.
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29
Total citations:
29
Citations from 2025:
6
(20.69%)
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MLA
Cite this
GOST
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Niculescu A. et al. New Applications of Lipid and Polymer-Based Nanoparticles for Nucleic Acids Delivery // Pharmaceutics. 2021. Vol. 13. No. 12. p. 2053.
GOST all authors (up to 50)
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Niculescu A., Bîrcă A. C., Grumezescu A. M. New Applications of Lipid and Polymer-Based Nanoparticles for Nucleic Acids Delivery // Pharmaceutics. 2021. Vol. 13. No. 12. p. 2053.
Cite this
RIS
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TY - JOUR
DO - 10.3390/pharmaceutics13122053
UR - https://doi.org/10.3390/pharmaceutics13122053
TI - New Applications of Lipid and Polymer-Based Nanoparticles for Nucleic Acids Delivery
T2 - Pharmaceutics
AU - Niculescu, Adelina-Gabriela
AU - Bîrcă, Alexandra Cătălina
AU - Grumezescu, Alexandru Mihai
PY - 2021
DA - 2021/12/01
PB - MDPI
SP - 2053
IS - 12
VL - 13
PMID - 34959335
SN - 1999-4923
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2021_Niculescu,
author = {Adelina-Gabriela Niculescu and Alexandra Cătălina Bîrcă and Alexandru Mihai Grumezescu},
title = {New Applications of Lipid and Polymer-Based Nanoparticles for Nucleic Acids Delivery},
journal = {Pharmaceutics},
year = {2021},
volume = {13},
publisher = {MDPI},
month = {dec},
url = {https://doi.org/10.3390/pharmaceutics13122053},
number = {12},
pages = {2053},
doi = {10.3390/pharmaceutics13122053}
}
Cite this
MLA
Copy
Niculescu, Adelina-Gabriela, et al. “New Applications of Lipid and Polymer-Based Nanoparticles for Nucleic Acids Delivery.” Pharmaceutics, vol. 13, no. 12, Dec. 2021, p. 2053. https://doi.org/10.3390/pharmaceutics13122053.