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Pharmaceutics, volume 14, issue 5, pages 1056

Renal Artery Catheterization for Microcapsules’Targeted Delivery to the Mouse Kidney

Gusliakova Olga I. ¹

Prikhozhdenko Ekaterina S. ¹

Plastun Valentina O. ¹

Mayorova Oksana A. ¹

Shushunova Natalia A ¹

Abdurashitov Arkady S. ²

Kulikov Oleg A. ³

Abakumov Maxim A. ⁴

Gorin Dmitry A. ⁵

Sukhorukov Gleb B. ^{2, 6}

Sindeeva Olga ^{1, 2}

Hide authors affiliations Show authors affiliations: 6 affiliations

Science Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia |

Center for Neurobiology and Brain Restoration, Skolkovo Institute of Science and Technology, 3 Nobel Str., 143005 Moscow, Russia |

Institute of Medicine, National Research Ogarev Mordovia State University, 68 Bolshevistskaya Str., 430005 Saransk, Russia |

⁴

Department of Medical Nanobiotecnology, Pirogov Russian National Research Medical University, 1 Ostrovityanova Str., 117997 Moscow, Russia |

⁵

Center for Photonics and Quantum Materials, Skolkovo Institute of Science and Technology, 3 Nobel Str., 143005 Moscow, Russia |

⁶

School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, UK |

Publication type: Journal Article

Publication date: 2022-05-14

Multidisciplinary Digital Publishing Institute (MDPI)

Journal: Pharmaceutics

Quartile SCImago

Quartile WOS

Impact factor: 5.4

ISSN: 19994923

DOI: 10.3390/pharmaceutics14051056

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PubMed ID: 35631642

Pharmaceutical Science

Abstract

The problem of reducing the side effects associated with drug distribution throughout the body in the treatment of various kidney diseases can be solved by effective targeted drug delivery. The method described herein involves injection of a drug encapsulated in polyelectrolyte capsules to achieve prolonged local release and long-term capillary retention of several hours while these capsules are administered via the renal artery. The proposed method does not imply disruption (puncture) of the renal artery or aorta and is suitable for long-term chronic experiments on mice. In this study, we compared how capsule size and dosage affect the target kidney blood flow. It has been established that an increase in the diameter of microcapsules by 29% (from 3.1 to 4.0 μm) requires a decrease in their concentration by at least 50% with the same suspension volume. The photoacoustic method, along with laser speckle contrast imaging, was shown to be useful for monitoring blood flow and selecting a safe dose. Capsules contribute to a longer retention of a macromolecular substance in the target kidney compared to its free form due to mechanical retention in capillaries and slow impregnation into surrounding tissues during the first 1–3 h, which was shown by fluorescence tomography and microscopy. At the same time, the ability of capillaries to perform almost complete “self-cleaning” from capsular shells during the first 12 h leads to the preservation of organ tissues in a normal state. The proposed strategy, which combines endovascular surgery and the injection of polymer microcapsules containing the active substance, can be successfully used to treat a wide range of nephropathies.

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	1
ACS applied materials & interfaces	ACS applied materials & interfaces, 1, 20% ACS applied materials & interfaces 1 publication, 20%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 20% International Journal of Molecular Sciences 1 publication, 20%
Pharmaceutics	Pharmaceutics, 1, 20% Pharmaceutics 1 publication, 20%
Colloids and Surfaces B: Biointerfaces	Colloids and Surfaces B: Biointerfaces, 1, 20% Colloids and Surfaces B: Biointerfaces 1 publication, 20%
ACS Applied Nano Materials	ACS Applied Nano Materials, 1, 20% ACS Applied Nano Materials 1 publication, 20%
	1

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	1 2
American Chemical Society (ACS)	American Chemical Society (ACS), 2, 40% American Chemical Society (ACS) 2 publications, 40%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 2, 40% Multidisciplinary Digital Publishing Institute (MDPI) 2 publications, 40%
Elsevier	Elsevier, 1, 20% Elsevier 1 publication, 20%
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Gusliakova O. I. et al. Renal Artery Catheterization for Microcapsules’Targeted Delivery to the Mouse Kidney // Pharmaceutics. 2022. Vol. 14. No. 5. p. 1056.

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Gusliakova O. I., Prikhozhdenko E. S., Plastun V. O., Mayorova O. A., Shushunova N. A., Abdurashitov A. S., Kulikov O. A., Abakumov M. A., Gorin D. A., Sukhorukov G. B., Sindeeva O. Renal Artery Catheterization for Microcapsules’Targeted Delivery to the Mouse Kidney // Pharmaceutics. 2022. Vol. 14. No. 5. p. 1056.

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RIS Copy

TY - JOUR

DO - 10.3390/pharmaceutics14051056

UR - https://doi.org/10.3390%2Fpharmaceutics14051056

TI - Renal Artery Catheterization for Microcapsules’Targeted Delivery to the Mouse Kidney

T2 - Pharmaceutics

AU - Plastun, Valentina O.

AU - Abdurashitov, Arkady S.

AU - Gusliakova, Olga I.

AU - Prikhozhdenko, Ekaterina S.

AU - Mayorova, Oksana A.

AU - Shushunova, Natalia A

AU - Kulikov, Oleg A.

AU - Abakumov, Maxim A.

AU - Gorin, Dmitry A.

AU - Sukhorukov, Gleb B.

AU - Sindeeva, Olga

PY - 2022

DA - 2022/05/14 00:00:00

PB - Multidisciplinary Digital Publishing Institute (MDPI)

SP - 1056

IS - 5

VL - 14

PMID - 35631642

SN - 1999-4923

ER -

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@article{2022_Gusliakova,

author = {Valentina O. Plastun and Arkady S. Abdurashitov and Olga I. Gusliakova and Ekaterina S. Prikhozhdenko and Oksana A. Mayorova and Natalia A Shushunova and Oleg A. Kulikov and Maxim A. Abakumov and Dmitry A. Gorin and Gleb B. Sukhorukov and Olga Sindeeva},

title = {Renal Artery Catheterization for Microcapsules’Targeted Delivery to the Mouse Kidney},

journal = {Pharmaceutics},

year = {2022},

volume = {14},

publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},

month = {may},

url = {https://doi.org/10.3390%2Fpharmaceutics14051056},

number = {5},

pages = {1056},

doi = {10.3390/pharmaceutics14051056}

}

MLA

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MLA Copy

Gusliakova, Olga I., et al. “Renal Artery Catheterization for Microcapsules’Targeted Delivery to the Mouse Kidney.” Pharmaceutics, vol. 14, no. 5, May. 2022, p. 1056. https://doi.org/10.3390%2Fpharmaceutics14051056.

Found error?

Publisher

Multidisciplinary Digital Publishing Institute (MDPI)

Journal

Pharmaceutics

Quartile SCImago

Quartile WOS

Impact factor

5.4

ISSN

19994923 (Print)

Labs

Biomedical Nanomaterials Laboratory

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